Olanzapine's effects on hypothalamic transcriptomics and kinase activity.

Humans Rats Animals Olanzapine / pharmacology Diabetes Mellitus, Type 2 / drug therapy Benzodiazepines / pharmacology Antipsychotic Agents / pharmacology Hypothalamus / metabolism Gene Expression Profiling
Kinome array Olanzapine RNA-seq

Journal

Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148

Informations de publication

Date de publication:
May 2024
Historique:
received: 21 09 2023
revised: 12 01 2024
accepted: 04 02 2024
medline: 18 3 2024
pubmed: 11 2 2024
entrez: 10 2 2024
Statut: ppublish

Résumé

Olanzapine is a second-generation antipsychotic that disrupts metabolism and is associated with an increased risk of type 2 diabetes. The hypothalamus is a key region in the control of whole-body metabolic homeostasis. The objective of the current study was to determine how acute peripheral olanzapine administration affects transcription and serine/threonine kinase activity in the hypothalamus. Hypothalamus samples from rats were collected following the pancreatic euglycemic clamp, thereby allowing us to study endpoints under steady state conditions for plasma glucose and insulin. Olanzapine stimulated pathways associated with inflammation, but diminished pathways associated with the capacity to combat endoplasmic reticulum stress and G protein-coupled receptor activity. These pathways represent potential targets to reduce the incidence of type 2 diabetes in patients taking antipsychotics.

Identifiants

DOI: 10.1016/j.psyneuen.2024.106987 PMID: 38340539
pubmed: 38340539
pii: S0306-4530(24)00031-3
doi: 10.1016/j.psyneuen.2024.106987
pii:
doi:

Substances chimiques

Olanzapine N7U69T4SZR
Benzodiazepines 12794-10-4
Antipsychotic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106987

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH107487
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121102
Pays : United States

Informations de copyright

Copyright © 2024 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest M.K.H. received consultant fees from Alkermes, Inc.

Auteurs

Sandra Pereira (S)

Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada.

Laura N Castellani (LN)

Centre for Addiction and Mental Health, Toronto, ON, Canada.

Chantel Kowalchuk (C)

Centre for Addiction and Mental Health, Toronto, ON, Canada.

Khaled Alganem (K)

Department of Neurosciences, University of Toledo, Toledo, OH, USA.

Xiaolu Zhang (X)

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

William G Ryan (WG)

Department of Neurosciences, University of Toledo, Toledo, OH, USA.

Raghunath Singh (R)

Centre for Addiction and Mental Health, Toronto, ON, Canada.

Sally Wu (S)

Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.

Emily Au (E)

Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

Roshanak Asgariroozbehani (R)

Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.

Sri Mahavir Agarwal (SM)

Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Banting & Best Diabetes Centre, Toronto, ON, Canada.

Adria Giacca (A)

Department of Physiology, University of Toronto, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada; Banting & Best Diabetes Centre, Toronto, ON, Canada.

Robert E Mccullumsmith (RE)

Department of Neurosciences, University of Toledo, Toledo, OH, USA; ProMedica, Neuroscience Institute, Toledo, OH, USA.

Margaret K Hahn (MK)

Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Banting & Best Diabetes Centre, Toronto, ON, Canada. Electronic address: margaret.hahn@camh.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Olanzapine's effects on hypothalamic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Olanzapine's effects on hypothalamic...
questionsmedicales.fr › Eucaryotes › Animaux › Olanzapine's effects on hypothalamic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Olanzapine › Olanzapine's effects on hypothalamic...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Olanzapine's effects on hypothalamic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Olanzapine's effects on hypothalamic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Olanzapine's effects on hypothalamic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Olanzapine's effects on hypothalamic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Olanzapine's effects on hypothalamic...