The role of intraamygdaloid oxytocin in spatial learning and avoidance learning.

amygdala learning memory oxytocin rat

Journal

Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690

Informations de publication

Date de publication:
08 Feb 2024
Historique:
received: 08 11 2023
revised: 26 01 2024
accepted: 06 02 2024
medline: 11 2 2024
pubmed: 11 2 2024
entrez: 10 2 2024
Statut: aheadofprint

Résumé

The goal of the present study is to investigate the role of intraamygdaloid oxytocin in learning-related mechanisms. Oxytocin is a neuropeptide which is involved in social bonding, trust, emotional responses and various social behaviors. By conducting passive avoidance and Morris water maze tests on male Wistar rats, the role of intraamygdaloid oxytocin in memory performance and learning was investigated. Oxytocin doses of 10ng and 100ng were injected into the central nucleus of the amygdala. Our results showed that 10ng oxytocin significantly reduced the time required to locate the platform during the Morris water maze test while significantly increasing the latency time in the passive avoidance test. However, the 100ng oxytocin experiment failed to produce a significant effect in either of the tests. Wistar rats pretreated with 20ng oxytocin receptor antagonist (L-2540) were administered 10ng of oxytocin into the central nucleus of the amygdala and were also subjected to the aforementioned tests to highlight the role of oxytocin receptors in spatial- and avoidance learning. Results suggest that oxytocin supports memory processing during both the passive avoidance and the Morris water maze tests. Oxytocin antagonists can however block the effects of oxytocin in both tests. The results substantiate that oxytocin uses oxytocin receptors to enhance memory and learning performance.

Identifiants

DOI: 10.1016/j.peptides.2024.171169 PMID: 38340898
pubmed: 38340898
pii: S0196-9781(24)00022-6
doi: 10.1016/j.peptides.2024.171169
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

171169

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Dávid Vörös (D)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

Orsolya Kiss (O)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

Márton Taigiszer (M)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

Bettina Réka László (BR)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary.

Tamás Ollman (T)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary; Learning in Biological and Artificial Systems Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

László Péczely (L)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary; Learning in Biological and Artificial Systems Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

Olga Zagorácz (O)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary; Learning in Biological and Artificial Systems Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

Erika Kertes (E)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary; Learning in Biological and Artificial Systems Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

Veronika Kállai (V)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary; Learning in Biological and Artificial Systems Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

Beáta Berta (B)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary; Learning in Biological and Artificial Systems Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary.

Anita Kovács (A)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary.

Zoltán Karádi (Z)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary; Cellular Bioimpedance Research Group, Szentágothai Research Center, University of Pécs, 7602 Pécs, Hungary; Molecular Endocrinology and Neurophysiology Research Group, Szentágothai Center, University of Pécs, 7602 Pécs, Hungary.

László Lénárd (L)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary; Molecular Endocrinology and Neurophysiology Research Group, Szentágothai Center, University of Pécs, 7602 Pécs, Hungary.

Kristóf László (K)

Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary; Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, 7602 Pécs, Hungary; Neuroscience Center, University of Pécs, 7602 Pécs, Hungary.

Classifications MeSH