Immunopathogenesis of Primary Biliary Cholangitis, Primary Sclerosing Cholangitis and Autoimmune Hepatitis: Themes and Concepts.

Dysbiosis Epidemiology Homing Tolerance Transplantation bile acids fibrosis genetics microbiome

Journal

Gastroenterology
ISSN: 1528-0012
Titre abrégé: Gastroenterology
Pays: United States
ID NLM: 0374630

Informations de publication

Date de publication:
09 Feb 2024
Historique:
received: 25 04 2023
revised: 21 01 2024
accepted: 28 01 2024
medline: 12 2 2024
pubmed: 12 2 2024
entrez: 11 2 2024
Statut: aheadofprint

Résumé

Autoimmune liver diseases (AILDs) include primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH), a family of chronic immune-mediated disorders that target hepatocytes and cholangiocytes. Treatments remain non-specific, variably effective and non-curative, and the need for liver transplantation is disproportionate to their rarity. Development of effective therapies requires better knowledge of pathogenic mechanisms, including the roles of genetic risk, and how the environment and gut dysbiosis cause immune cell dysfunction and aberrant bile acid signalling. This review summarises key aetiolopathogenic concepts and themes relevant for clinical practice, and how such learnings can guide the development of new therapies for people living with AILDs.

Identifiants

DOI: 10.1053/j.gastro.2024.01.049 PMID: 38342195
pubmed: 38342195
pii: S0016-5085(24)00165-3
doi: 10.1053/j.gastro.2024.01.049
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 AGA Institute. Published by Elsevier Inc. All rights reserved.

Auteurs

Palak J Trivedi (PJ)

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham Birmingham, UK; Liver Unit, University Hospitals Birmingham Birmingham, UK; Institute of Translational Medicine, University of Birmingham, Birmingham, UK.

Gideon M Hirschfield (GM)

Toronto Centre for Liver Disease, Division of Gastroenterology and Hepatology, University of Toronto, Toronto, Ontario, Canada.

David H Adams (DH)

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham Birmingham, UK; Liver Unit, University Hospitals Birmingham Birmingham, UK.

John M Vierling (JM)

Departments of Medicine and Surgery, Section of Gastroenterology and Hepatology, Division of Abdominal TransplantationBaylor College of Medicine, Houston, Texas, USA. Electronic address: vierling@bcm.edu.

Classifications MeSH