Effects of Boric acid as Maternal Feed Additives on the Development and Sex Ratio of Mouse pups.
Boric acid
Breeding
Reproduction
Sex ratio
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
12 Feb 2024
12 Feb 2024
Historique:
received:
21
12
2023
accepted:
07
02
2024
medline:
12
2
2024
pubmed:
12
2
2024
entrez:
11
2
2024
Statut:
aheadofprint
Résumé
Boron is primarily used in industrial applications, with recent interest revolving around its effects on metabolism. In this study, we administered boric acid (BA), which has positive effects on reproduction, in conjunction with feed supplementation to serve as a model for experimental animal development and breeding. The pregnancy performance, offspring development, and biochemical effects of mice given feed supplemented with BA at concentrations of 0 (control group), 250, and 500 ppm (BA groups) were investigated. A total of 18 female Balb-C mice were utilized for pregnancy. The mice were given the BA-supplemented feed during a period encompassing three weeks of pregnancy and three weeks of lactation. The numbers and weights of offspring born in cages on days 19-21 were determined. Blood and tissue samples were collected from the offspring during the third week postnatal, and the malondialdehyde (MDA) and total antioxidant and oxidant status (TAS, TOS, and OSI) levels were determined. A significant increase in female offspring was observed in the groups born to mice fed with BA compared to the control group. Positive development in organ weights was observed in the 250-ppm BA group. The 250-ppm group exhibited a significant increase in TAS compared to the control group, while TOS and MDA levels showed a decrease. Also, the levels of BA groups were found to decrease in both the OSI index serum and organ samples compared to the control group. Thus, the use of 250-ppm BA demonstrated positive effects on female offspring production, organ development, and antioxidant levels.
Identifiants
pubmed: 38342845
doi: 10.1007/s12011-024-04099-3
pii: 10.1007/s12011-024-04099-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Coates PM, Cragg GM, Levine M, Moss J, White JD, Marcel Dekker (2005) Encyclopedia of dietary supplements. In: Hunter C (ed) Boron. CRC, New York, pp 55–65. https://doi.org/10.1201/b14669
doi: 10.1201/b14669
Nielsen FH (1997) Boron in human and animal nutrition. Plant Soil 193:199–208. https://doi.org/10.1023/A:1004276311956
doi: 10.1023/A:1004276311956
Sogut I, Oglakci A, Kartkaya K, Ol-Kusat K, Sogut-Savasan M, Kanbak G, InalErden M (2015) Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Exp Ther Med 9:1023–1027. https://doi.org/10.3892/etm.2014.2164
doi: 10.3892/etm.2014.2164
pubmed: 25667671
Yalcin CO, Abudayyak M (2020) Effects of boric acid on cell death and oxidative stress of mouse TM3 leydig cells invitro. J Trace Elem Med Biol 61:126506. https://doi.org/10.1016/j.jtemb.2020.126506
doi: 10.1016/j.jtemb.2020.126506
pubmed: 32299013
Ince S, Erdogan M, Demierel HS, Agca Y, Dal G, Uguz C (2018) Boron enhances early embryonic gene expressions and improves fetal development of rats. J Trace Elem Med Biol 50:34–46. https://doi.org/10.1016/j.jtemb.2018.06.002
doi: 10.1016/j.jtemb.2018.06.002
pubmed: 30262302
İnce S, Küçükkurt I, Ciğerci IH, Fidan AF, Eryavuz A (2010) The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity and DNA damage in rats. J Trace Elem Med Biol 24:161–164. https://doi.org/10.1016/j.jtemb.2010.01.003
doi: 10.1016/j.jtemb.2010.01.003
pubmed: 20569927
Fort D, Stover E, Strong PL, Murray FJ, Keen JL (1999) Chronic feeding of a low boron diet adversely affect reproduction and development in xenopus laevis. J Nutr 129:2055–2060. https://doi.org/10.1093/jn/129.11.2055
doi: 10.1093/jn/129.11.2055
pubmed: 10539784
Pavel H, Büyükgüzel E, Büyükgüzel K (2007) The effects of boric acid-induced oxidative stress on antioxidant enzymes and survivorship in Galleria mellonella. Arch Insect Biochem Physiol 66(1):23–31. https://doi.org/10.1002/arch.20194
doi: 10.1002/arch.20194
Turkez H, Geyikoglu F (2010) Boric acid: a potential chemoprotective agent against aflatoxin b(1)toxicity in human blood. Cytotech 62(2):157–165. https://doi.org/10.1007/s10616-010-9272-2
doi: 10.1007/s10616-010-9272-2
Aktas A, Esener OB, Yigit F, Bozkurt HH, Ulkay MB, Gulipek GI, Akyazi I, Eraslan E (2017) Effects of different doses of boric acid injected into chicken egg on bursa of fabricius and spleen: a histological and stereological study. Kafkas Univ Vet Fak Derg 23(2):185–193
Bhasker TV, Gowda NK, Pal DT, Bhat SK, Krishnamoorthy P, Mondal S, Pattanaik AK, Verma AK (2017) Influence of boron supplementation on performance, immunity and antioxidant status of lambs fed diets with or without adequate level of calcium. PLoS ONE 12(11):e0187203. https://doi.org/10.1371/journal.pone.0187203
doi: 10.1371/journal.pone.0187203
pubmed: 29141035
pmcid: 5687717
Ammerman CB, Baker DH, Lewis AS (1995) Bioavailibility of nutrients for animals: amino acid, Minerals, and vitamins. Academic Pres. San Diego. CA
Kocabay A, Taskin AC (2023) Boric acid improved cryopreserved mouse embryo development. Biol Trace Elem Res 1–5. https://doi.org/10.1007/s12011-023-03990-9
Zeng B et al (2019) The beneficial effects of Moringa oleifera leaf on reproductive performance in mice. Food Sci Nutr 7:2: 738–746
doi: 10.1002/fsn3.918
pubmed: 30847152
pmcid: 6392826
Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351–358
doi: 10.1016/0003-2697(79)90738-3
pubmed: 36810
Benzie IFF (2003) Evolution of dietary antioxidants. Comp Biochem Physiol Part A 136:113–126. https://doi.org/10.1016/S1095-6433(02)00368-9
doi: 10.1016/S1095-6433(02)00368-9
Kurtoglu V Effects of boron supplementation on performance and some serum biochemical parameters in laying hens. Y. Revue deédecine Vétérinaire 153.12: 823–828., Heindel JJ, Price CJ, Schwetz BA et al (2002) (1994). The developmental toxicity of boric acid in mice, rats and rabbits. Environ Health Perspect 107. https://doi.org/10.1289/ehp.94102s7107
Heindel JJ, Price CJ, Schwetz BA (1994) The developmental toxicity of boric acid in mice, rats and rabbits. Environ Health Perspect 107. https://doi.org/10.1289/ehp.94102s7107
Sırmatel Ö, Sert C, Sırmatel F, Selek Ş, Yokus B (2007) Total antioxidant capacity,total oxidant status and oxidative stres index in the men exposed to1.5 tstatic magnetic field. Gen Physiol Biophys 26:86–90
pubmed: 17660581
Romero FJ, Bosch-Morell F, Romero MJ, Jareño EJ, Romero B, Marín N, Romá J (1998) Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect 106:1229–1234. https://doi.org/10.1289/ehp.98106s51229
doi: 10.1289/ehp.98106s51229
pubmed: 9788902
pmcid: 1533372
Robbıns W, Weı F, Elashoff Da, Wu G, Xun L, Jıa J (2008) Y:X sperm ratio in boron-exposed men. J Androl 29:115–121. https://doi.org/10.2164/jandrol.107.003541
doi: 10.2164/jandrol.107.003541
pubmed: 17881766
Scialli AR, Bonde JP, Brüske-Hohlfeld I, Culver BD, Li Y, Sullivan FM (2010) An overview of male reproductive studies of boron with an emphasis on studies of highly exposed Chinese workers. Reprod Toxicol 29:10–24
doi: 10.1016/j.reprotox.2009.10.006
pubmed: 19850122
Rosenfeld CS, Grimm KM, Livingston KA, Brokman AM, Lamberson WE, Roberts RM (2003) Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. PNAS 100(8):4628–4632
doi: 10.1073/pnas.0330808100
pubmed: 12672968
pmcid: 153606
Emsen E, Yaprak M (2006) Effect of controlled breeding on the fertility of Awassi and Red Karaman ewes and the performance of the offspring. Small Rum Res 66(1–3):230–235. https://doi.org/10.1016/j.smallrumres.2005.09.022
doi: 10.1016/j.smallrumres.2005.09.022
Hornig LE, McClintock MK (1996) Male sexual rest affects litter sex ratio of newborn Norway rats. Anim Behav 51:991–1005. https://doi.org/10.1006/anbe.1996.010235
doi: 10.1006/anbe.1996.010235
King WA, Yadav BR, Xu KP, Picard L, Sirard MA, Vernini Supplizi A, Betteridge KJ (1991) The sex ratios of bovine embryos produced in vivo and in vitro. Theriogenology 36:779–788. https://doi.org/10.1016/0093-691X(91)90343-C
doi: 10.1016/0093-691X(91)90343-C
pubmed: 16727046
Paul A, Kuester J (1987) Sex ratio adjustment in a seasonally breeding primate species: evidence from a Barbary macaque population at Affenberg Salem. Ethology 74:117–132. https://doi.org/10.1111/j.1439-0310.1987.tb00925.x
doi: 10.1111/j.1439-0310.1987.tb00925.x
Wehner GR, Wood C, Tague A, Barker D, Hubert H (1997) Efficiency of the ovatec unit for estrus detection and calf sex control in beef cows. Anim Reprod Sci 46:27–34. https://doi.org/10.1016/S0378-4320(96)01604-1
doi: 10.1016/S0378-4320(96)01604-1
pubmed: 9231244