Analysis of the transplacental transmission of SARS CoV-2 virus and antibody transfer according to the gestational age at maternal infection.

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
11 Feb 2024
Historique:
received: 01 10 2023
accepted: 02 02 2024
medline: 12 2 2024
pubmed: 12 2 2024
entrez: 11 2 2024
Statut: epublish

Résumé

To quantify transplacental transmission of SARS-CoV-2 virus and antibody transfer in pregnant women and their newborns according to the gestational age at maternal infection. A prospective observational multicenter study including pregnant women with a positive RT-PCR or a positive serology for SARS-CoV-2 and compatible symptoms, from April to December 2020, in 11 French maternities. The study was designed to obtain a systematic collection of mother-infant dyad's samples at birth. SARS-CoV-2 viral load was measured by RT-PCR. IgG and IgM antibodies against the SARS-CoV-2 spike protein were measured by enzyme-linked immunosorbent assay. Antibody concentrations and transplacental transfer ratios were analyzed according to the gestational age at maternal infection. The primary outcome was the rate of SARS CoV-2 materno-fetal transmission at birth. The secondary outcome was the quantification of materno-fetal antibody transfer. Maternal and neonatal outcomes at birth were additionally assessed. Among 165 dyads enrolled, one congenital infection was confirmed {n = 1 (0.63%) IC

Identifiants

DOI: 10.1038/s41598-024-53580-5 PMID: 38342940
pubmed: 38342940
doi: 10.1038/s41598-024-53580-5
pii: 10.1038/s41598-024-53580-5
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3458

Informations de copyright

© 2024. The Author(s).

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Auteurs

Louise Lucot-Royer (L)

Pôle Mère-Femme, Department of Obstetrics and Gynecology, University Hospital of Besancon, University of Franche-Comte, Alexander Fleming Boulevard, 25000, Besançon, France.

Camille Nallet (C)

Pôle Mère-Femme, Department of Obstetrics and Gynecology, University Hospital of Besancon, University of Franche-Comte, Alexander Fleming Boulevard, 25000, Besançon, France.

Manon Vouga (M)

Pôle Mère-Femme, Department of Obstetrics and Gynecology, University Hospital of Besancon, University of Franche-Comte, Alexander Fleming Boulevard, 25000, Besançon, France.

Marc Puyraveau (M)

Pôle Mère-Femme, Department of Obstetrics and Gynecology, University Hospital of Besancon, University of Franche-Comte, Alexander Fleming Boulevard, 25000, Besançon, France.

Frederic Mauny (F)

Pôle Mère-Femme, Department of Obstetrics and Gynecology, University Hospital of Besancon, University of Franche-Comte, Alexander Fleming Boulevard, 25000, Besançon, France.

Solène Marty-Quinternet (S)

Nanomedicine Lab, Imagery and Therapeutics, EA4662, University of Franche-Comte, 25000, Besançoon, France.

Charline Bertholdt (C)

Department of Obstetrics and Gynecology, University Hospital of Nancy, Nancy Hopital Central, 54000, Nancy, France.

Jean-Paul Bory (JP)

Department of Obstetrics and Gynecology, University Hospital of Reims, 51092, Reims, France.

Christine Devalland (C)

Department of Obstetrics and Gynecology, Hopital Nord Franche Comté, 90400, Trévenans, France.

Margaux Canaguier (M)

Department of Obstetrics and Gynecology, Hopital Nord Franche Comté, 90400, Trévenans, France.

Camille Copolla (C)

Department of Obstetrics and Gynecology, Groupe Hospitalier de la Haute-Saone, 70000, Vesoul, France.

Marie-Laure Eszto (ML)

Department of Obstetrics and Gynecology, CHR Metz-Thionville, 57100, Thionville, France.

Yohny Montoya (Y)

Department of Obstetrics and Gynecology, CHR Metz-Thionville, 57100, Thionville, France.

Marion Roesch (M)

Department of Obstetrics and Gynecology, CHR Metz-Thionville, 57100, Thionville, France.

Sandrine Reviron (S)

Department of Obstetrics and Gynecology, Hopital Jura Sud, 39000, Lons-Le-Saunier, France.

Didier Riethmuller (D)

Department of Obstetrics and Gynecology, University Hospital of Grenoble, CHU Grenoble Alpes, 38700, La Tronche, France.

Emma Rufenacht (E)

Department of Obstetrics and Gynecology, Centre Hospitalier Intercommunal de Haute Comté, 25300, Pontarlier, France.

Emmanuel Simon (E)

Department of Obstetrics and Gynecology, University Hospital of Dijon, CHU Mitterand, 21000, Dijon, France.

Nicolas Mottet (N)

Pôle Mère-Femme, Department of Obstetrics and Gynecology, University Hospital of Besancon, University of Franche-Comte, Alexander Fleming Boulevard, 25000, Besançon, France. n1mottet@chu-besancon.fr.

Classifications MeSH