Focal Nodular Hyperplasia: A Comprehensive Review with a Particular Focus on Pathogenesis and Complications.
Focal nodular hyperplasia
Liver lesion
Oral contraceptives
Journal
Journal of clinical and translational hepatology
ISSN: 2310-8819
Titre abrégé: J Clin Transl Hepatol
Pays: United States
ID NLM: 101649815
Informations de publication
Date de publication:
28 Feb 2024
28 Feb 2024
Historique:
received:
09
06
2023
revised:
27
09
2023
accepted:
09
11
2023
medline:
12
2
2024
pubmed:
12
2
2024
entrez:
12
2
2024
Statut:
ppublish
Résumé
Focal nodular hyperplasia is a benign tumor of the liver that is often found incidentally with imaging. The purpose of this review is to discuss the pathophysiology, rare complications that can occur due to these lesions, and management options. A literature review was performed on clinical trials and case reports involving focal nodular hyperplasia complications and management of these, as well as the proposed pathogenesis underlying these tumors. Although exposure to oral contraceptive pills and endogenous hormones have been thought to play a role in the development of these lesions, this has not been proven. Most recently, they are thought to arise as a consequence of a vascular anomaly causing alterations in the expression of angiopoietin genes. Complications are rare, but previous cases have reported associated pain, rupture and compression of nearby structures (hepatic vein, stomach, biliary system). Resection of focal nodular hyperplasia is not usually recommended. However, if there is associated pain with no other identifiable cause or presence of a large or growing lesion with risk of causing a complication, then surgical resection, radiofrequency ablation or arterial embolization should be considered.
Identifiants
pubmed: 38343607
doi: 10.14218/JCTH.2023.00265
pii: JCTH.2023.00265
pmc: PMC10851072
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
182-190Informations de copyright
© 2024 Authors.
Déclaration de conflit d'intérêts
GYW has been an editor-in-chief of Journal of Clinical and Translational Hepatology since 2013, JVK has no conflict of interests related to this publication.
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