Excitatory action of low frequency depolarizing GABA/glycine synaptic inputs is prevalent in prenatal spinal SOD1
ALS disease
SOD1G93A mouse
depolarizing GABA/glycine potentials
lumbar motoneuron
modelling
patch clamp recording
prenatal stage
spinal cord
synaptic event integration
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
12 Feb 2024
12 Feb 2024
Historique:
received:
01
06
2023
accepted:
24
01
2024
medline:
12
2
2024
pubmed:
12
2
2024
entrez:
12
2
2024
Statut:
aheadofprint
Résumé
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease characterized by progressive motor neuron degeneration and muscle paralysis. Recent evidence suggests the dysfunction of inhibitory signalling in ALS motor neurons. We have shown that embryonic day (E)17.5 spinal motoneurons (MNs) of the SOD1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone
ID : AAP2018
Organisme : AFM-TELETHON
ID : 23185
Informations de copyright
© 2024 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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