Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation.
SOX9
development
growth plate cartilage
mouse model
skeletal growth
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
20 Feb 2024
20 Feb 2024
Historique:
medline:
13
2
2024
pubmed:
12
2
2024
entrez:
12
2
2024
Statut:
ppublish
Résumé
SOX8 was linked in a genome-wide association study to human height heritability, but roles in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 remain unknown. We undertook here to fill this knowledge gap. High-throughput assays demonstrate expression of human
Identifiants
pubmed: 38346197
doi: 10.1073/pnas.2316969121
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2316969121Subventions
Organisme : HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
ID : AR072649 AR080062
Organisme : Université de Caen Normandie (UNICAEN)
ID : not applicable
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.