Genomic attributes of airway commensal bacteria and mucosa.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
12 Feb 2024
12 Feb 2024
Historique:
received:
30
01
2023
accepted:
22
01
2024
medline:
13
2
2024
pubmed:
13
2
2024
entrez:
12
2
2024
Statut:
epublish
Résumé
Microbial communities at the airway mucosal barrier are conserved and highly ordered, in likelihood reflecting co-evolution with human host factors. Freed of selection to digest nutrients, the airway microbiome underpins cognate management of mucosal immunity and pathogen resistance. We show here the initial results of systematic culture and whole-genome sequencing of the thoracic airway bacteria, identifying 52 novel species amongst 126 organisms that constitute 75% of commensals typically present in heathy individuals. Clinically relevant genes encode antimicrobial synthesis, adhesion and biofilm formation, immune modulation, iron utilisation, nitrous oxide (NO) metabolism and sphingolipid signalling. Using whole-genome content we identify dysbiotic features that may influence asthma and chronic obstructive pulmonary disease. We match isolate gene content to transcripts and metabolites expressed late in airway epithelial differentiation, identifying pathways to sustain host interactions with microbiota. Our results provide a systematic basis for decrypting interactions between commensals, pathogens, and mucosa in lung diseases of global significance.
Identifiants
pubmed: 38347162
doi: 10.1038/s42003-024-05840-3
pii: 10.1038/s42003-024-05840-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
171Subventions
Organisme : Wellcome Trust (Wellcome)
ID : WT098051; WT206194 and 108413/A/15/D
Organisme : Wellcome Trust (Wellcome)
ID : 215359/Z/19/Z
Organisme : Wellcome Trust (Wellcome)
ID : WT096964MA and WT097117MA
Organisme : Office of Science, Government of Western Australia
ID : Busselton Healthy Ageing Study
Informations de copyright
© 2024. The Author(s).
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