A multiscale characterization of cortical shape asymmetries in early psychosis.

cortical asymmetry early psychosis eigenmode decomposition spectral shape analysis

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2024
Historique:
received: 12 10 2023
revised: 29 12 2023
accepted: 19 01 2024
medline: 13 2 2024
pubmed: 13 2 2024
entrez: 13 2 2024
Statut: epublish

Résumé

Psychosis has often been linked to abnormal cortical asymmetry, but prior results have been inconsistent. Here, we applied a novel spectral shape analysis to characterize cortical shape asymmetries in patients with early psychosis across different spatial scales. We used the Human Connectome Project for Early Psychosis dataset (aged 16-35), comprising 56 healthy controls (37 males, 19 females) and 112 patients with early psychosis (68 males, 44 females). We quantified shape variations of each hemisphere over different spatial frequencies and applied a general linear model to compare differences between healthy controls and patients with early psychosis. We further used canonical correlation analysis to examine associations between shape asymmetries and clinical symptoms. Cortical shape asymmetries, spanning wavelengths from about 22 to 75 mm, were significantly different between healthy controls and patients with early psychosis (Cohen's

Identifiants

DOI: 10.1093/braincomms/fcae015 PMID: 38347944 PMC: PMC10859637
pubmed: 38347944
doi: 10.1093/braincomms/fcae015
pii: fcae015
pmc: PMC10859637
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcae015

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.

Déclaration de conflit d'intérêts

K.M.A. is the Scientific Director and a shareholder of BrainKey Inc., a medical image analysis software company. The other authors declare that they have no competing interests.

Auteurs

Yu-Chi Chen (YC)

School of Psychological Sciences, Turner Institute for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Data Futures Institute, Monash University, Melbourne 3800, Australia.
Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.
Brain Dynamic Centre, Westmead Institute for Medical Research, University of Sydney, Sydney 2145, Australia.
ORCID: 0000-0001-9167-6417

Jeggan Tiego (J)

School of Psychological Sciences, Turner Institute for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
ORCID: 0000-0001-7835-6398

Ashlea Segal (A)

School of Psychological Sciences, Turner Institute for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Department of Psychology, Yale University, New Haven, CT 06511, USA.

Sidhant Chopra (S)

Department of Psychology, Yale University, New Haven, CT 06511, USA.
ORCID: 0000-0003-0866-3477

Alexander Holmes (A)

School of Psychological Sciences, Turner Institute for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.

Chao Suo (C)

School of Psychological Sciences, Turner Institute for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
BrainPark, School of Psychological Sciences, Monash University, Melbourne 3800, Australia.

James C Pang (JC)

School of Psychological Sciences, Turner Institute for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.

Alex Fornito (A)

School of Psychological Sciences, Turner Institute for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.

Kevin M Aquino (KM)

School of Psychological Sciences, Turner Institute for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
Monash Biomedical Imaging, Monash University, Melbourne 3800, Australia.
School of Physics, University of Sydney, Sydney 2050, Australia.
Center of Excellence for Integrative Brain Function, University of Sydney, Sydney 2050, Australia.
BrainKey Inc, San Francisco, CA 94103, USA.

Classifications MeSH