5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review.

The review begins with an overview of the fundamental principles/physics underlying light, fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence spectroscopy methods used in neurosurgery (e.g., intensity, time-resolved) and in so doing, describe their specific features (e.g., hardware requirements, main processing methods) as well as their strengths and limitations. Finally, we review current clinical applications and future directions of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy in neurosurgery.

Informations de copyright

Copyright © 2024 Gautheron, Bernstock, Picart, Guyotat, Valdés and Montcel.

Déclaration de conflit d'intérêts

PV is a consultant for an unrelated imaging study for NX Development Corp and has multiple patents or provisional patents on fluorescence imaging technologies for fluorescence-guided neurosurgery. PV and JB have equity in Lumiere Optix. JB has an equity position in Treovir Inc. and UpFront Diagnostics. JB is also on the Centile Bioscience, QV Bioelectronics, and NeuroX1 boards of scientific advisors. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.