Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
Feb 2024
Historique:
medline: 13 2 2024
pubmed: 13 2 2024
entrez: 13 2 2024
Statut: ppublish

Résumé

Background Image-guided tumor ablation is the first-line therapy for early-stage hepatocellular carcinoma (HCC), with ongoing investigations into its combination with immunotherapies. Matrix metalloproteinase (MMP) inhibition demonstrates immunomodulatory potential and reduces HCC tumor growth when combined with ablative treatment. Purpose To evaluate the effect of incomplete cryoablation with or without MMP inhibition on the local immune response in residual tumors in a murine HCC model. Materials and Methods Sixty 8- to 10-week-old female BALB/c mice underwent HCC induction with use of orthotopic implantation of syngeneic Tib-75 cells. After 7 days, mice with a single lesion were randomized into treatment groups: (

Identifiants

DOI: 10.1148/radiol.232365 PMID: 38349244
pubmed: 38349244
doi: 10.1148/radiol.232365
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e232365

Auteurs

Annabella Shewarega (A)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0003-0663-3047

Jessica G Santana (JG)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0002-4370-5823

David Nam (D)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0002-4650-5691

Antonia Berz (A)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).

Jonathan Tefera (J)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).

Vinzent Kahl (V)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0009-0008-7516-5842

Sandeep K Mishra (SK)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0002-1016-0206

Daniel Coman (D)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0002-6289-0817

James Duncan (J)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0002-5167-9856

Scott J Roberts (SJ)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0001-8473-1721

Axel Wetter (A)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).

David C Madoff (DC)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0003-3461-437X

Julius Chapiro (J)

From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
ORCID: 0000-0002-1984-2246

Classifications MeSH