2-Thioxo-3,4-dihydropyrimidine and thiourea endowed with sulfonamide moieties as dual EGFR
EGFRT790M and VEGFR-2 dual inhibitors
anticancer agents
docking
sulfonamides
thiourea
Journal
Drug development research
ISSN: 1098-2299
Titre abrégé: Drug Dev Res
Pays: United States
ID NLM: 8204468
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
revised:
18
11
2023
received:
03
10
2023
accepted:
16
12
2023
medline:
13
2
2024
pubmed:
13
2
2024
entrez:
13
2
2024
Statut:
ppublish
Résumé
The effectiveness of a new series of thiopyrimidine and thiourea containing sulfonamides moieties was tested on HCT-116, MCF-7, HepG2, and A549. HepG2 cell line was the one that all the new derivatives affected the most. The greatest potent compounds against the four HepG2, HCT116, MCF-7, and A549 cell lines were 8f and 8g with IC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22143Informations de copyright
© 2024 Wiley Periodicals LLC.
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