Long-term results after surgical basal cell carcinoma excision in the eyelid region: revisited.
Basal cell carcinoma
Eyelid
Periocular
Recurrence rate
Surgical excision
Journal
Wiener klinische Wochenschrift
ISSN: 1613-7671
Titre abrégé: Wien Klin Wochenschr
Pays: Austria
ID NLM: 21620870R
Informations de publication
Date de publication:
13 Feb 2024
13 Feb 2024
Historique:
received:
06
12
2023
accepted:
22
01
2024
medline:
13
2
2024
pubmed:
13
2
2024
entrez:
13
2
2024
Statut:
aheadofprint
Résumé
The aim of the study was to readdress basal cell carcinoma (BCC) in the periocular region to prove the efficacy of histologically controlled surgical treatment and to identify high-risk characteristics.Retrospective analysis of 451 microscopically controlled BCC excisions in the periocular region. Tumor location, tumor size, AJCC 7 classification, and histological results were recorded. The same procedure was followed for recurrences.A recurrence rate of 5.0% was observed after the first microscopically controlled excision. Recurrent BCCs show a shift from nodular to sclerosing BCC as the primary histological type as well as a change in primary location from lower eyelid to medial canthus. The frequency of BCC with deep extension increased from 7.3% to 24.7%, and 57.1% after the second and third operations, respectively. The recurrence rate increased to 9.5% and 42.9%, after the second and third operations, respectively.In conclusion, we are facing the same challenges in surgical BCC treatment as 30 years ago. The distribution of periocular BCC location, histologic subtype and recurrence rates mirror the literature und the general consensus. The recurrence rate increases with every operation needed. Sclerosing BCCs with deep extension at the medial canthus bear the greatest risk for recurrence. In such cases, centers of expertise should be consulted and additional treatment options should be considered.
Identifiants
pubmed: 38349412
doi: 10.1007/s00508-024-02333-5
pii: 10.1007/s00508-024-02333-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Rubin AI, Chen EH, Ratner D. Basal-cell carcinoma. N Engl J Med. 2005;353(21):2262–9.
doi: 10.1056/NEJMra044151
pubmed: 16306523
Cook BE, Jr., Bartley GB. Treatment options and future prospects for the management of eyelid malignancies: an evidence-based update. Ophthalmology. 2001;108(11):2088–98; quiz 99–100, 121.
Pe’er J. Pathology of eyelid tumors. Indian J Ophthalmol. 2016;64(3):177–90.
doi: 10.4103/0301-4738.181752
pubmed: 27146927
pmcid: 4869455
Saleh GM, Desai P, Collin JR, Ives A, Jones T, Hussain B. Incidence of eyelid basal cell carcinoma in England: 2000–2010. Br J Ophthalmol. 2017;101(2):209–12.
doi: 10.1136/bjophthalmol-2015-308261
pubmed: 27130914
Bas Z, Sharpe J, Yaghy A, Zhang Q, Shields CL, Hyman L, et al. Prevalence of and Associated Factors for Eyelid Cancer in the American Academy of Ophthalmology Intelligent Research in Sight Registry. Ophthalmol. Sci. 2023;3(1):100227.
Malhotra R, Huilgol SC, Huynh NT, Selva D. The Australian Mohs database, part I: periocular basal cell carcinoma experience over 7 years. Ophthalmology. 2004;111(4):624–30.
doi: 10.1016/j.ophtha.2003.12.003
pubmed: 15051192
Vitaliano PP, Urbach F. The Relative Importance of Risk Factors in Nonmelanoma Carcinoma. Arch Dermatol. 1980;116(4):454–6.
doi: 10.1001/archderm.1980.01640280090030
pubmed: 7369779
Beyer-Machule C, Riedel K. Basal cell carcinoma. Principles and Practice of Ophthalmology Clinical Practice. Philadelphia, PA: WB Saunders; 1994. pp. 1724–33.
Nasr I, McGrath EJ, Harwood CA, Botting J, Buckley P, Budny PG, et al. British Association of Dermatologists guidelines for the management of adults with basal cell carcinoma 2021. Br J Dermatol. 2021;185(5):899–920.
doi: 10.1111/bjd.20524
pubmed: 34050920
Pieh S, Kuchar A, Novak P, Kunstfeld R, Nagel G, Steinkogler FJ. Long-term results after surgical basal cell carcinoma excision in the eyelid region. Br J Ophthalmol. 1999;83(1):85–8.
doi: 10.1136/bjo.83.1.85
pubmed: 10209442
pmcid: 1722795
Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471–4.
Saldanha G, Fletcher A, Slater D. Basal cell carcinoma: a dermatopathological and molecular biological update. Br J Dermatology. 2003;148(2):195–202.
doi: 10.1046/j.1365-2133.2003.05151.x
Saldanha G, Fletcher A, Slater DN. Basal cell carcinoma: a dermatopathological and molecular biological update. Br J Dermatol. 2003;148(2):195–202.
doi: 10.1046/j.1365-2133.2003.05151.x
pubmed: 12588368
Mohs FE. Chemosurgery for the microscopically controlled excision of cutaneous cancer. Head Neck Surg. 1978;1(2):150–66.
doi: 10.1002/hed.2890010209
pubmed: 755808
Bittner GC, Cerci FB, Kubo EM, Tolkachjov SN. Mohs micrographic surgery: a review of indications, technique, outcomes, and considerations. An Bras Dermatol. 2021;96(3):263–77.
doi: 10.1016/j.abd.2020.10.004
pubmed: 33849752
pmcid: 8178571
Robins P, Albom MJ. Mohs’ surgery—fresh tissue technique. J Dermatol Surg. 1975;1(2):37–41.
doi: 10.1111/j.1524-4725.1975.tb00069.x
pubmed: 1223151
Schell AE, Russell MA, Park SS. Suggested excisional margins for cutaneous malignant lesions based on Mohs micrographic surgery. JAMA Facial Plast Surg. 2013;15(5):337–43.
doi: 10.1001/jamafacial.2013.1011
pubmed: 23744451
Max R, Esteban O‑O, Life Expectancy HR. OurWorldInData.org. Available from: https://ourworldindata.org/life-expectancy . 2013. last access: 12.02.24
Galindo-Ferreiro A, Sanchez-Tocino H, Diez-Montero C, Belani-Raju M, Garcia-Sanz R, Diego-Alonso M, et al. Characteristics and Recurrence of Primary Eyelid Basal Cell Carcinoma in Central Spain. J Curr Ophthalmol. 2020;32(2):183–8.
doi: 10.4103/JOCO.JOCO_28_20
pubmed: 32671303
pmcid: 7337017
Auw-Haedrich C, Frick S, Boehringer D, Mittelviefhaus H. Histologic safety margin in basal cell carcinoma of the eyelid: correlation with recurrence rate. Ophthalmology. 2009;116(4:802–6.
doi: 10.1016/j.ophtha.2008.11.012
Pons S, Zwetyenga N, Bonniaud B, Carime AN, Delfour C, Durand L, et al. Observational study of a series of basal cell carcinomas: Evaluation of location as a risk factor for recurrence. J Stomatol Oral Maxillofac Surg. 2022;123(6):655–9.
doi: 10.1016/j.jormas.2022.05.012
pubmed: 35644379
Dethmers A, Low U, Langenbucher A, Flockerzi F, Bohle RM, Seitz B. Recurrence risk of periocular basal cell carcinoma after histologically controlled excision. Ophthalmologie. 2022;.
Juniat V, Shah P, Vonica O, Daniel CS, Murta F. Periocular basal cell carcinoma recurrence following surgical treatment: Safe surveillance time. Eye (Lond). 2022;.
Poignet B, Gardrat S, Dendale R, Lemaitre S, Lumbroso-Le Rouic L, Desjardins L, et al. Basal cell carcinomas of the eyelid: Results of an initial surgical management. J Fr Ophtalmol. 2019;42(10):1094–9.
doi: 10.1016/j.jfo.2019.03.037
pubmed: 31727330
Weesie F, Naus NC, Vasilic D, Hollestein LM, van den Bos RR, Wakkee M. Recurrence of periocular basal cell carcinoma and squamous cell carcinoma after Mohs micrographic surgery: a retrospective cohort study. Br J Dermatol. 2019;180(5):1176–82.
doi: 10.1111/bjd.17516
pubmed: 30536656
pmcid: 6849866
Sin CW, Barua A, Cook A. Recurrence rates of periocular basal cell carcinoma following Mohs micrographic surgery: a retrospective study. Int J Dermatol. 2016;55(9):1044–7.
doi: 10.1111/ijd.13326
pubmed: 27152747
Rowe DE, Carroll RJ, Day CL Jr.. Long-term recurrence rates in previously untreated (primary) basal cell carcinoma: implications for patient follow-up. J Dermatol Surg Oncol. 1989;15(3):315–28.
doi: 10.1111/j.1524-4725.1989.tb03166.x
pubmed: 2646336
Malhotra R, Huilgol SC, Huynh NT, Selva D. The Australian Mohs database, part II: periocular basal cell carcinoma outcome at 5‑year follow-up. Ophthalmology. 2004;111(4):631–6.
doi: 10.1016/j.ophtha.2003.11.004
pubmed: 15051193
Litwin AS, Rytina E, Ha T, Rene C, Woodruff SA. Management of periocular basal cell carcinoma by Mohs micrographic surgery. J Dermatolog Treat. 2013;24(3):232–4.
doi: 10.3109/09546634.2012.690506
pubmed: 22551161
Lindgren G, Lindblom B, Larko O. Mohs’ micrographic surgery for basal cell carcinomas on the eyelids and medial canthal area. II. Reconstruction and follow-up. Acta Ophthalmol Scand. 2000;78(4):430–6.
doi: 10.1034/j.1600-0420.2000.078004430.x
pubmed: 10990046
Alekseeva AK, Ganicheva EI, Simonian I. The effectiveness of treating children with chronic pneumonia in specialized suburban sanatoria. Vopr Kurortol Fizioter Lech Fiz Kult. 1972;37(2):126–8.
pubmed: 5051193
Lin Z, Qidwai U, Igali L, Hemmant B. A multicentre review of the histology of 1012 periocular basal cell carcinomas. Eur J Ophthalmol. 2021;31(5):2699–704.
doi: 10.1177/1120672120957597
pubmed: 32907383
Amin M, Edge S, Greene F. Carcinoma of the eyelid. In: AJCC Cancer Staging Manual. Springer New York; 2016.