Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
drug development
itch
kcnt1
slack
target validation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
13 Feb 2024
13 Feb 2024
Historique:
revised:
15
01
2024
received:
29
09
2023
medline:
14
2
2024
pubmed:
14
2
2024
entrez:
13
2
2024
Statut:
aheadofprint
Résumé
Various disorders are accompanied by histamine-independent itching, which is often resistant to the currently available therapies. Here, it is reported that the pharmacological activation of Slack (Kcnt1, K
Identifiants
pubmed: 38350720
doi: 10.1002/advs.202307237
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2307237Subventions
Organisme : Else Kröner-Fresenius-Stiftung
ID : 2018_A95
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 2158
Organisme : Structural Genomics Consortium (SGC)
ID : 1097737
Organisme : German Cancer Research Center (DKTK)
Organisme : Frankfurt Cancer Institute (FCI)
Organisme : Molecular and Functional Characterization of Selective Autophagy
ID : SFB 1177
Organisme : ICR
Organisme : FUGG
ID : INST 161/920-1 FUGG
Informations de copyright
© 2024 The Authors. Advanced Science published by Wiley-VCH GmbH.
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