The Search for Antidotes Against Ricin.

Drug design Ribosome-inactivating protein Ricin inhibitors chemical warfare medicinal chemistry ricin A chain

Journal

Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212

Informations de publication

Date de publication:
23 Jan 2024
Historique:
received: 04 07 2023
revised: 30 09 2023
accepted: 18 10 2023
medline: 14 2 2024
pubmed: 14 2 2024
entrez: 13 2 2024
Statut: aheadofprint

Résumé

The castor plant (Ricinus communis) is primarily known for its seeds, which contain a unique fatty acid called ricinoleic acid with several industrial and commercial applications. Castor seeds also contain ricin, a toxin considered a chemical and biological warfare agent. Despite years of investigation, there is still no effective antidote or vaccine available. However, some progress has been made, and the development of an effective treatment may be on the horizon. To provide an updated overview of this issue, we have conducted a comprehensive review of the literature on the current state of research in the fight against ricin. This mini-review is based on the reported research and aims to address the challenges faced by researchers, as well as highlight the most successful cases achieved thus far. Our goal is to encourage the scientific community to continue their efforts in this critical search.

Identifiants

pubmed: 38350844
pii: MRMC-EPUB-137680
doi: 10.2174/0113895575270509231121060105
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Fernanda Diniz Botelho (FD)

Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMCBD), Military Institute of Engineering, Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Brazil.

Tanos Celmar Costa Franca (TCC)

Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMCBD), Military Institute of Engineering, Praça General Tibúrcio 80, 22290-270, Rio de Janeiro, RJ, Brazil.
Université de Québec, INRS - Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec, H7V 1B7, Canada.
Department of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové, Czech Republic.

Steven R LaPlante (SR)

Université de Québec, INRS - Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec, H7V 1B7, Canada.

Classifications MeSH