Impact of COVID-19 pandemic on thyroidectomy for malignant diseases in high-volume referral centers.
COVID-19 pandemic
Complications
Thyroid carcinoma
Thyroid surgery
Thyroidectomy
Volume outcome
Journal
Updates in surgery
ISSN: 2038-3312
Titre abrégé: Updates Surg
Pays: Italy
ID NLM: 101539818
Informations de publication
Date de publication:
13 Feb 2024
13 Feb 2024
Historique:
received:
10
08
2023
accepted:
29
01
2024
medline:
14
2
2024
pubmed:
14
2
2024
entrez:
13
2
2024
Statut:
aheadofprint
Résumé
The COVID-19 pandemic has limited the availability of healthcare resources for non-COVID patients and decreased elective surgeries, including thyroidectomy. Despite the prioritization of surgical procedures, it has been reported that thyroidectomy for thyroid cancer (TCa) was adversely impacted. We assessed the impact of the pandemic on the surgical activities of two high-volume referral centers. Patients operated at two National Referral Centers for Thyroid Surgery between 03/01/2020 and 02/28/2021 (COVID-19 period) were included (P-Group). The cohort was compared with patients operated at the same Centers between 03/01/2019 and 02/29/2020 (pre-COVID-19 pandemic) (C-Group). Overall, 7017 patients were included: 2782 in the P-Group and 4235 in the C-Group. The absolute number of patients with TCa was not significantly different between the two groups, while the rate of malignant disease was significantly higher in the P-Group (1103/2782 vs 1190/4235) (P < 0.0001). Significantly more patients in the P-Group had central (237/1103 vs 232/1190) and lateral (167/1103 vs 140/1190) neck node metastases (P = 0.001). Overall, the complications rate was significantly lower (11.9% vs 15.1%) and hospital stay was significantly shorter (1.7 ± 1.5 vs 1.9 ± 2.2 days) in the P-Group (P < 0.05). The COVID-19 pandemic significantly decreased the overall number of thyroidectomies but did not affect the number of operations for TCa. Optimization of management protocols, due to limited resource availability for non-COVID patients, positively impacted the complication rate and hospital stay.
Identifiants
pubmed: 38351271
doi: 10.1007/s13304-024-01771-0
pii: 10.1007/s13304-024-01771-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. Italian Society of Surgery (SIC).
Références
Nickel B, Glover A, Miller JA (2021) Delays to Low-risk Thyroid cancer treatment during COVID-19-refocusing from what has been lost to what may be learned and gained. JAMA Otolaryngol Head Neck Surg 147:5–6
doi: 10.1001/jamaoto.2020.3878
pubmed: 33119084
Zhao Y, Xu X (2020) Thyroid surgery during COVID-19 pandemic: is it feasible? Br J Surg 107: e424
Scappaticcio L, Pitoia F, Esposito K et al (2020) Impact of COVID-19 on the thyroid gland: an update. Rev Endocr Metab Disord 25:1–13
Smulever A, Abelleira E, Bueno F et al (2020) Thyroid cancer in the Era of COVID-19. Endocrine 70:1–5
doi: 10.1007/s12020-020-02439-6
pubmed: 32754886
pmcid: 7402074
Hojaij FC, Chinelatto LA, Boog GHP et al (2020) Head and neck practice in the COVID-19 pandemics today: a rapid systematic review. Int Arch Otorhinolaryngol 24:e518–e526
doi: 10.1055/s-0040-1715506
pubmed: 33101521
pmcid: 7575400
Tsang VHM, Gild M, Glover A et al (2020) Thyroid cancer in the age of COVID-19. Endocr Relat Cancer 27:R407–R416
doi: 10.1530/ERC-20-0279
pubmed: 32810844
Baud G, Brunaud L, Lifante JC, AFCE COVID Study Group et al (2020) Endocrine surgery during and after the COVID-19 epidemic: Expert guidelines from AFCE. J Visc Surg 157:S43–S49
doi: 10.1016/j.jviscsurg.2020.04.018
pubmed: 32448761
pmcid: 7190473
Shaha AR (2020) Thyroid surgery during COVID-19 pandemic: principles and philosophies. Head Neck 42:1322–1324
doi: 10.1002/hed.26198
pubmed: 32338793
pmcid: 7267442
Jozaghi Y, Zafereo ME, Perrier ND et al (2020) Endocrine surgery in the Coronavirus disease 2019 pandemic: Surgical Triage Guidelines. Head Neck 42:1325–1328
doi: 10.1002/hed.26169
pubmed: 32437031
pmcid: 7262055
Mehanna H, Hardman JC, Shenson JA et al (2020) Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus. Lancet Oncol 21:e350–e359
doi: 10.1016/S1470-2045(20)30334-X
pubmed: 32534633
pmcid: 7289563
Topf MC, Shenson JA, Holsinger FC et al (2002) Framework for prioritizing head and neck surgery during the COVID-19 pandemic. Head Neck 42:1159–1167
doi: 10.1002/hed.26184
Vrachimis A, Iakovou I, Giannoula E et al (2020) Endocrinology in the time of COVID-19: management of thyroid nodules and cancer. Eur J Endocrinol 183:G41–G48
doi: 10.1530/EJE-20-0269
pubmed: 32438345
pmcid: 7938009
Boelaert K, Visser WE, Taylor PN et al (2020) Endocrinology in the time of COVID-19: management of hyperthyroidism and hypothyroidism. Eur J Endocrinol 183:G33–G39
doi: 10.1530/EJE-20-0445
pubmed: 32438340
pmcid: 7938012
Spartalis E, Plakopitis N, Theodori MA et al (2021) Thyroid cancer surgery during the coronavirus disease 2019 pandemic: perioperative management and oncological and anatomical considerations. Future Oncol 17(32):4389–4395
doi: 10.2217/fon-2021-0585
pubmed: 34431326
Scappaticcio L, Maiorino MI, Iorio S et al (2022) Thyroid surgery during the COVID-19 pandemic: results from a systematic review. J Endocrinol Invest 45(1):181–188
doi: 10.1007/s40618-021-01641-1
pubmed: 34282552
Medas F, Ansaldo GL, Avenia N, SIUEC Collaborative Group et al (2021) The THYCOVIT (Thyroid Surgery during COVID-19 pandemic in Italy) study: results from a nationwide, multicentric, case-controlled study. Updates Surg 16:1–9
Kim SH, Min E, Hwang YM, Choi YS, Yi JW (2022) Impact of COVID-19 pandemic on thyroid surgery in a University Hospital in South Korea. Cancers (Basel) 14(17):4338
doi: 10.3390/cancers14174338
pubmed: 36077872
Liu H, Zhan L, Guo L et al (2021) More aggressive cancer behaviour in thyroid cancer patients in the post-COVID-19 pandemic era: a retrospective study. Int J Gen Med 14:7197–7206
doi: 10.2147/IJGM.S339998
pubmed: 34737615
pmcid: 8558635
Vigliar E, Pisapia P, Dello Iacovo F et al (2022) COVID-19 pandemic impact on cytopathology practice in the post-lockdown period: an international, multicenter study. Cancer Cytopathol 130(5):344–351
doi: 10.1002/cncy.22547
pubmed: 35006650
pmcid: 9015399
Palladino R, Migliatico I, Sgariglia R et al (2021) Thyroid fine-needle aspiration trends before, during, and after the lockdown: what we have learned so far from the COVID-19 pandemic. Endocrine 71:20–25
doi: 10.1007/s12020-020-02559-z
pubmed: 33284396
Collins RA, DiGennaro C, Beninato T, et al (2022) Limited disease progression in endocrine surgery patients with treatment delays due to COVID-19. Surgery 29
Bakkar S, Al-Omar K, Aljarrah Q et al (2020) Impact of COVID-19 on thyroid cancer surgery and adjunct therapy. Updates Surg 72:867–869
doi: 10.1007/s13304-020-00833-3
pubmed: 32537687
pmcid: 7293828
Cai YC, Wang W, Li C et al (2020) Treating head and neck tumors during the SARS-CoV-2 epidemic, 2019 to 2020: Sichuan Cancer Hospital. Head Neck 42:1153–1158
doi: 10.1002/hed.26161
pubmed: 32270568
pmcid: 7262070
COVIDSurg Collaborative, (2021) Head and neck cancer surgery during the COVID-19 pandemic: an international, multicenter, observational cohort study. Cancer 127(14):2476–2488
doi: 10.1002/cncr.33320
Lombardi CP, D’Amore A, Grani G et al (2020) Endocrine surgery during COVID-19 pandemic: do we need an update of indications in Italy? Endocrine 68:485–488
doi: 10.1007/s12020-020-02357-7
pubmed: 32500518
pmcid: 7270156
Wai KC, Xu MJ, Lee RH et al (2021) Head and neck surgery during the coronavirus-19 pandemic: The University of California San Francisco experience. Head Neck 43:622–629
doi: 10.1002/hed.26514
pubmed: 33098178
Zhang D, Fu Y, Zhou L et al (2020) Thyroid surgery during coronavirus-19 pandemic phases I, II and III: lessons learned in China, South Korea. Iran and Italy J Endocrinol Invest 44(5):1065–1073
doi: 10.1007/s40618-020-01407-1
pubmed: 32876925
Zhao Y, Jin C, Song Q et al (2021) Surgical management and outcome of patients with thyroid disease during the COVID-19 pandemic. Br J Surg 108:e22–e23
doi: 10.1093/bjs/znaa056
pubmed: 33640933
Ferrari M, Paderno A, Giannini L et al (2021) COVID-19 screening protocols for preoperative assessment of head and neck cancer patients candidate for elective surgery in the midst of the pandemic: a narrative review with comparison between two Italian institutions. Oral Oncol 112:105043
doi: 10.1016/j.oraloncology.2020.105043
pubmed: 33129056
Ministero della salute. http://www.salute.gov.it/portale/nuovocoronavirus/homeNuovoCorona virus.jsp.GazzettaUfficiale. Accessed Dec 15, 2022
Haugen BR, Alexander EK, Bible KC et al (2016) 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26:1e133
doi: 10.1089/thy.2015.0020
Pacini F, Basolo F, Bellantone R et al (2018) Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of 6 Italian societies. J Endocrinol Invest 41:849e876
doi: 10.1007/s40618-018-0884-2
Amin MB, Edge S, Greene F et al (2017) AJCC cancer staging manual, 8th edn. Springer, New York
Carty SE, Cooper DS, Doherty GM et al (2009) Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. Thyroid 19:1153e1158
doi: 10.1089/thy.2009.0159
Stack BC, Ferris RL, Goldenberg D et al (2012) American Thyroid Association consensus review and statement regarding the anatomy, terminology, and rationale for lateral neck dissection in differentiated thyroid cancer. Thyroid 22:501–508
doi: 10.1089/thy.2011.0312
pubmed: 22435914
Naguib R (2022) Potential relationships between COVID-19 and the thyroid gland: an update. J Int Med Res 50(2):3000605221082898
doi: 10.1177/03000605221082898
pubmed: 35226548
Falcone R, Grani G, Ramundo V et al (2020) Cancer care during COVID-19 era: the quality of life of patients with thyroid malignancies. Front Oncol 10:1128
doi: 10.3389/fonc.2020.01128
pubmed: 32714873
pmcid: 7344223
Sessa L, De Crea C, Zotta F et al (2022) Post-thyroidectomy hypocalcemia: is a routine preferable over a selective supplementation? Am J Surg 223(6):1126–1131
doi: 10.1016/j.amjsurg.2021.10.015
pubmed: 34711410