The development of early human lymphatic vessels as characterized by lymphatic endothelial markers.
Cellular Origin of Lymphatic Endothelial Cells
Human Embryos
Lymphatic Vessel Development
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
14 Feb 2024
14 Feb 2024
Historique:
received:
09
11
2023
accepted:
08
01
2024
revised:
02
01
2024
medline:
14
2
2024
pubmed:
14
2
2024
entrez:
14
2
2024
Statut:
aheadofprint
Résumé
Lymphatic vessel development studies in mice and zebrafish models have demonstrated that lymphatic endothelial cells (LECs) predominantly differentiate from venous endothelial cells via the expression of the transcription factor Prox1. However, LECs can also be generated from undifferentiated mesoderm, suggesting potential diversity in their precursor cell origins depending on the organ or anatomical location. Despite these advances, recapitulating human lymphatic malformations in animal models has been difficult, and considering lymphatic vasculature function varies widely between species, analysis of development directly in humans is needed. Here, we examined early lymphatic development in humans by analyzing the histology of 31 embryos and three 9-week-old fetuses. We found that human embryonic cardinal veins, which converged to form initial lymph sacs, produce Prox1-expressing LECs. Furthermore, we describe the lymphatic vessel development in various organs and observe organ-specific differences. These characterizations of the early development of human lymphatic vessels should help to better understand the evolution and phylogenetic relationships of lymphatic systems, and their roles in human disease.
Identifiants
pubmed: 38351385
doi: 10.1038/s44318-024-00045-0
pii: 10.1038/s44318-024-00045-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20K17072
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 23K15949
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 22jm0610079h0001
Organisme : Mie University (Mie)
ID : Interdisciplinary Collaborative Research Support Project
Informations de copyright
© 2024. The Author(s).
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