Clinical efficacy of intense pulsed light combined with low-dose intralesional corticosteroids in treating noninfectious granulomas after mesotherapy: A case series analysis.
corticosteroids
granulomas
intense pulsed light
mesotherapy
therapy
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
13 Feb 2024
13 Feb 2024
Historique:
revised:
10
01
2024
received:
19
10
2023
accepted:
23
01
2024
medline:
14
2
2024
pubmed:
14
2
2024
entrez:
14
2
2024
Statut:
aheadofprint
Résumé
Mesotherapy is a popular cosmetic procedure for localized delivery of substances. However, due to the lack of standardized processes, there are potential risks of adverse reactions. Granulomas formation is one of the chronic reactions which impose significant physical and mental burdens on patients. The aim of this analysis is to evaluate the safety and feasibility of combining intense pulsed light (IPL) with intralesional corticosteroids for treating noninfectious granulomas after mesotherapy. This retrospective observational case series included patients who suffer from noninfectious granulomas after mesotherapy and received combination of IPL and intralesional corticosteroids treatment between October 2021 and December 2022 at Peking University Shenzhen Hospital, Shenzhen, China. The process and effect were analyzed and summarized. Among the seven patients, five expressed extreme satisfaction with the efficacy, while two was slightly satisfied. The physicians believed that all patients had shown significant improvement. No adverse reactions or recurrences were observed during follow-up. Based on this analysis, the application of the combined treatment in patients suffering from noninfectious granuloma due to mesotherapy demonstrates good clinical efficacy and safety, making it worth considering as a treatment option.
Sections du résumé
BACKGROUND
BACKGROUND
Mesotherapy is a popular cosmetic procedure for localized delivery of substances. However, due to the lack of standardized processes, there are potential risks of adverse reactions. Granulomas formation is one of the chronic reactions which impose significant physical and mental burdens on patients.
OBJECTIVES
OBJECTIVE
The aim of this analysis is to evaluate the safety and feasibility of combining intense pulsed light (IPL) with intralesional corticosteroids for treating noninfectious granulomas after mesotherapy.
METHODS
METHODS
This retrospective observational case series included patients who suffer from noninfectious granulomas after mesotherapy and received combination of IPL and intralesional corticosteroids treatment between October 2021 and December 2022 at Peking University Shenzhen Hospital, Shenzhen, China. The process and effect were analyzed and summarized.
RESULTS
RESULTS
Among the seven patients, five expressed extreme satisfaction with the efficacy, while two was slightly satisfied. The physicians believed that all patients had shown significant improvement. No adverse reactions or recurrences were observed during follow-up.
CONCLUSION
CONCLUSIONS
Based on this analysis, the application of the combined treatment in patients suffering from noninfectious granuloma due to mesotherapy demonstrates good clinical efficacy and safety, making it worth considering as a treatment option.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Shenzhen Key Medical Discipline Construction Fund
ID : SZXK040
Organisme : Shenzhen Sanming Project
ID : SZSM201812059
Informations de copyright
© 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
Références
Pistor M. What is mesotherapy? Chir Dent Fr. 1976;46(288):59-60.
El-Domyati M, El-Ammawi TS, Moawad O, et al. Efficacy of mesotherapy in facial rejuvenation: a histological and immunohistochemical evaluation. Int J Dermatol. 2012;51(8):913-919.
Savoia A, Landi S, Baldi A. A new minimally invasive mesotherapy technique for facial rejuvenation. Dermatol Ther (Heidelb). 2013;3(1):83-93.
Plachouri KM, Georgiou S. Mesotherapy: safety profile and management of complications. J Cosmet Dermatol. 2019;18(6):1601-1605.
Kutlubay Z, Gokalp H, Ince U, Engin B. Cutaneous foreign body granulomas associated with lipolytic cocktail: who is the enemy, mesotherapy or drugs injected? J Cosmet Laser Ther. 2017;19(5):310-312.
Pagán AJ, Ramakrishnan L. The formation and function of granulomas. Annu Rev Immunol. 2018;36:639-665.
Veraldi S, Spigariolo CB, Nazzaro G, Colonna C, Gianotti R, Cusini M. Suppurative and granulomatous lesions of the skin following mesotherapy. Ital J Dermatol Venerol. 2022;157(3):285-286.
Narins RS, Coleman WP 3rd, Glogau RG. Recommendations and treatment options for nodules and other filler complications. Dermatol Surg. 2009;35(Suppl 2):1667-1671.
Zhang Q, Yang L, Yang F, Liu L, Jiang X. Mesotherapy-induced cutaneous foreign body-type granulomatous reaction in the face treated with minocycline: case report and literature review. Clin Cosmet Investig Dermatol. 2023;16:861-867.
Sales AFS, Pandolfo IL, de Almeida CM, et al. Intense pulsed light on skin rejuvenation: a systematic review. Arch Dermatol Res. 2022;314(9):823-838.
Gokdemir G, Küçükünal A, Sakiz D. Cutaneous granulomatous reaction from mesotherapy. Dermatol Surg. 2009;35(2):291-293.
Strahan JE, Cohen JL, Chorny JA. Granuloma annulare as a complication of mesotherapy: a case report. Dermatol Surg. 2008;34(6):836-838.
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E. Cutaneous granulomatosis: a comprehensive review. Clin Rev Allergy Immunol. 2018;54(1):131-146.
Lee JM, Kim YJ. Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Arch Plast Surg. 2015;42(2):232-239.
Chandawarkar AA, Provenzano DJ, Rad AN, et al. Learning curves: historical trends of FDA-reported adverse events for dermal fillers. Cutis. 2018;102(2):E20-E23.
Lemperle G, Rullan PP, Gauthier-Hazan N. Avoiding and treating dermal filler complications. Plast Reconstr Surg. 2006;118(3 Suppl):92S-107S.
Bigatà X, Ribera M, Bielsa I, Ferrándiz C. Adverse granulomatous reaction after cosmetic dermal silicone injection. Dermatol Surg. 2001;27(2):198-200.
Hong JK, Sun B, Shin SH, Kim BJ. Late-onset filler-induced granuloma after Polycaprolactone-based filler treated with high-intensity focused ultrasound and quantum molecular resonance technology. Dermatol Surg. 2022;48(6):693-694.
Wang YC, Gao TW, Liu B, et al. Treatment of facial wrinkles injection caused foreign body granulomas with post operative erythema with IPL plus local steroid injection. J Clin Dermatol. 2012;41(12):765-766.
Cuerda-Galindo E, Díaz-Gil G, Palomar-Gallego MA, Linares-GarcíaValdecasas R. Intense pulsed light induces synthesis of dermal extracellular proteins in vitro. Lasers Med Sci. 2015;30(7):1931-1939.