Immune modulation by rural exposures and allergy protection.
asthma
environment
immune
protection
rural
Journal
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
revised:
23
01
2024
received:
24
11
2023
accepted:
24
01
2024
medline:
14
2
2024
pubmed:
14
2
2024
entrez:
14
2
2024
Statut:
ppublish
Résumé
Growing up on traditional farms protects children from the development of asthma and allergies. However, we have identified distinct asthma-protective factors, such as poultry exposure. This study aims to examine the biological effect of rural exposure in China. We recruited 67 rural children (7.4 ± 0.9 years) and 79 urban children (6.8 ± 0.6 years). Depending on the personal history of exposure to domestic poultry (DP), rural children were further divided into those with DP exposure (DP There was a stepwise increase in the percentage of eosinophils (%) from rural DP Immune responses of rural children were dampened compared to urban children and those exposed to DP had further downregulated immune responsiveness. DP dust extracts ameliorated Th2-driven allergic airway inflammation in mice. Determining active protective components in the rural environment may provide directions for the development of primary prevention of asthma.
Sections du résumé
BACKGROUND
BACKGROUND
Growing up on traditional farms protects children from the development of asthma and allergies. However, we have identified distinct asthma-protective factors, such as poultry exposure. This study aims to examine the biological effect of rural exposure in China.
METHODS
METHODS
We recruited 67 rural children (7.4 ± 0.9 years) and 79 urban children (6.8 ± 0.6 years). Depending on the personal history of exposure to domestic poultry (DP), rural children were further divided into those with DP exposure (DP
RESULTS
RESULTS
There was a stepwise increase in the percentage of eosinophils (%) from rural DP
CONCLUSIONS
CONCLUSIONS
Immune responses of rural children were dampened compared to urban children and those exposed to DP had further downregulated immune responsiveness. DP dust extracts ameliorated Th2-driven allergic airway inflammation in mice. Determining active protective components in the rural environment may provide directions for the development of primary prevention of asthma.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14086Subventions
Organisme : The T.S. Lo Foundation
Organisme : The Research Grants Council of Hong Kong General Research Fund
ID : 14119320
Organisme : The Chinese University of Hong Kong Research Committee Postdoctoral Fellowship Scheme
Organisme : National Natural Science Foundation of China
ID : 82161138020
Organisme : National Natural Science Foundation of China
ID : 82300031
Informations de copyright
© 2024 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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