Association of Nirmatrelvir/Ritonavir Treatment and COVID-19-Neutralizing Antibody Titers in a Longitudinal Health Care Worker Cohort.

COVID-19 NMV/r antibodies antivirals humoral immune response immunology longitudinal cohort

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Feb 2024
Historique:
received: 30 06 2023
medline: 14 2 2024
pubmed: 14 2 2024
entrez: 14 2 2024
Statut: epublish

Résumé

Nirmatrelvir/ritonavir (NMV/r) is used for the treatment of coronavirus disease 2019 (COVID-19) infection. However, rebound COVID-19 infections can occur after taking NMV/r. We examined neutralizing antibodies to the severe acute respiratory syndrome coronavirus 2 spike protein before and after infection in people who did and did not take NMV/r to determine if NMV/r impedes the humoral immune response.

Identifiants

pubmed: 38352152
doi: 10.1093/ofid/ofad625
pii: ofad625
pmc: PMC10863641
doi:

Types de publication

Journal Article

Langues

eng

Pagination

ofad625

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Déclaration de conflit d'intérêts

Potential conflicts of interest. All authors report no potential conflicts.

Auteurs

Slade Decker (S)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Shaoming Xiao (S)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Carly Dillen (C)

Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Christina M Schumacher (CM)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Aaron M Milstone (AM)

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Matthew Frieman (M)

Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Amanda K Debes (AK)

Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Classifications MeSH