Serum free light chains among twin siblings: is the kappa/lambda ratio genetically determined?
Kappa and lambda free light chains
biological variation
reference ranges
Journal
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
ISSN: 1366-5804
Titre abrégé: Biomarkers
Pays: England
ID NLM: 9606000
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
medline:
12
3
2024
pubmed:
14
2
2024
entrez:
14
2
2024
Statut:
ppublish
Résumé
Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation studies conducted on healthy subjects showed that free light chains have a low within and high between-individual variation. We determined if this variation were genetically linked. We obtained a single serum sample from 16 pairs of identical twins, 8 neonate twins, and 19 presumed directly-related siblings children, measured Κ and λ light chains and computed the Κ/λ ratio. As expected, Κ/λ results from each twin neonate were near identical (reflecting maternal/placental transfer). For older children and adult twins, the Κ/λ ratio form a cluster of results that were a subset of the reference range. There was one outlier, a female with a high, different from her twin sister. She likely had a monoclonal gammopathy (no followup was possible). Excluding this pair, results from neonate twins (14.4% ±10.3%) and non-neonate twins (18.0 ± 15.3%) were not significantly different. Results between non-twin siblings were more scattered (53.2%±53.4%) and different from neonate and non-neonate twin adult and children. We suggest that the Κ/λ free light chains may be genetically linked.
Sections du résumé
BACKGROUND
UNASSIGNED
Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation studies conducted on healthy subjects showed that free light chains have a low within and high between-individual variation. We determined if this variation were genetically linked.
METHODS
UNASSIGNED
We obtained a single serum sample from 16 pairs of identical twins, 8 neonate twins, and 19 presumed directly-related siblings children, measured Κ and λ light chains and computed the Κ/λ ratio.
RESULTS
UNASSIGNED
As expected, Κ/λ results from each twin neonate were near identical (reflecting maternal/placental transfer). For older children and adult twins, the Κ/λ ratio form a cluster of results that were a subset of the reference range. There was one outlier, a female with a high, different from her twin sister. She likely had a monoclonal gammopathy (no followup was possible). Excluding this pair, results from neonate twins (14.4% ±10.3%) and non-neonate twins (18.0 ± 15.3%) were not significantly different. Results between non-twin siblings were more scattered (53.2%±53.4%) and different from neonate and non-neonate twin adult and children.
CONCLUSION
UNASSIGNED
We suggest that the Κ/λ free light chains may be genetically linked.
Identifiants
pubmed: 38353603
doi: 10.1080/1354750X.2024.2319308
doi:
Substances chimiques
Immunoglobulin kappa-Chains
0
Immunoglobulin lambda-Chains
0
Immunoglobulin Light Chains
0
Types de publication
Twin Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM