Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies.

COVID-19 Frailty Multimorbidity Multiple chronic conditions SARS-CoV-2

Journal

Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995

Informations de publication

Date de publication:
14 Feb 2024
Historique:
received: 09 11 2023
accepted: 29 11 2023
medline: 14 2 2024
pubmed: 14 2 2024
entrez: 14 2 2024
Statut: epublish

Résumé

Estimating the risks and impacts of COVID-19 for different health groups at the population level is essential for orienting public health measures. Adopting a population-based approach, we conducted a systematic review to explore: (1) the etiological role of multimorbidity and frailty in developing SARS-CoV-2 infection and COVID-19-related short-term outcomes; and (2) the prognostic role of multimorbidity and frailty in developing short- and long-term outcomes. This review presents the state of the evidence in the early years of the pandemic. It was conducted within the European Union Horizon 2020 program (No: 101018317); Prospero registration: CRD42021249444. PubMed, Embase, World Health Organisation COVID-19 Global literature on coronavirus disease, and PsycINFO were searched between January 2020 and 7 April 2021 for multimorbidity and 1 February 2022 for frailty. Quantitative peer-reviewed studies published in English with population-representative samples and validated multimorbidity and frailty tools were considered. Overall, 9,701 records were screened by title/abstract and 267 with full text. Finally, 14 studies were retained for multimorbidity (etiological role, n = 2; prognostic, n = 13) and 5 for frailty (etiological role, n = 2; prognostic, n = 4). Only short-term outcomes, mainly mortality, were identified. An elevated likelihood of poorer outcomes was associated with an increasing number of diseases, a higher Charlson Comorbidity Index, different disease combinations, and an increasing frailty level. Future studies, which include the effects of recent virus variants, repeated exposure and vaccination, will be useful for comparing the possible evolution of the associations observed in the earlier waves.

Sections du résumé

BACKGROUND BACKGROUND
Estimating the risks and impacts of COVID-19 for different health groups at the population level is essential for orienting public health measures. Adopting a population-based approach, we conducted a systematic review to explore: (1) the etiological role of multimorbidity and frailty in developing SARS-CoV-2 infection and COVID-19-related short-term outcomes; and (2) the prognostic role of multimorbidity and frailty in developing short- and long-term outcomes. This review presents the state of the evidence in the early years of the pandemic. It was conducted within the European Union Horizon 2020 program (No: 101018317); Prospero registration: CRD42021249444.
METHODS METHODS
PubMed, Embase, World Health Organisation COVID-19 Global literature on coronavirus disease, and PsycINFO were searched between January 2020 and 7 April 2021 for multimorbidity and 1 February 2022 for frailty. Quantitative peer-reviewed studies published in English with population-representative samples and validated multimorbidity and frailty tools were considered.
RESULTS RESULTS
Overall, 9,701 records were screened by title/abstract and 267 with full text. Finally, 14 studies were retained for multimorbidity (etiological role, n = 2; prognostic, n = 13) and 5 for frailty (etiological role, n = 2; prognostic, n = 4). Only short-term outcomes, mainly mortality, were identified. An elevated likelihood of poorer outcomes was associated with an increasing number of diseases, a higher Charlson Comorbidity Index, different disease combinations, and an increasing frailty level.
DISCUSSION CONCLUSIONS
Future studies, which include the effects of recent virus variants, repeated exposure and vaccination, will be useful for comparing the possible evolution of the associations observed in the earlier waves.

Identifiants

DOI: 10.1007/s40520-023-02685-4 PMID: 38353841
pubmed: 38353841
doi: 10.1007/s40520-023-02685-4
pii: 10.1007/s40520-023-02685-4
doi:

Types de publication

Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

40

Informations de copyright

© 2024. The Author(s).

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Auteurs

Tatjana T Makovski (TT)

Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France. tatjana.makovski@santepubliquefrance.fr.

Jinane Ghattas (J)

Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium.
Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium.

Stéphanie Monnier-Besnard (S)

Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France.

Lisa Cavillot (L)

Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium.
Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium.

Monika Ambrožová (M)

National screening centre, Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic.
Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Barbora Vašinová (B)

National screening centre, Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic.

Rodrigo Feteira-Santos (R)

Área Disciplinar Autónoma de Bioestatística, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Laboratório Associado TERRA, Instituto de Saúde Ambiental, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Peter Bezzegh (P)

Directorate for Project Management, National Directorate General for Hospitals, Budapest, Hungary.

Felipe Ponce Bollmann (FP)

Universidad Nacional de Educación a Distancia, Madrid, Spain.

James Cottam (J)

Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium.
Institute of Tropical Medicine, Antwerp, Belgium.

Romana Haneef (R)

Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France.

Brecht Devleesschauwer (B)

Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium.
Department of Translational Physiology, Infectiology and Public Health, Ghent University, Merelbeke, Belgium.

Niko Speybroeck (N)

Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium.

Paulo Jorge Nogueira (PJ)

Área Disciplinar Autónoma de Bioestatística, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Laboratório Associado TERRA, Instituto de Saúde Ambiental, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Centro de Investigação Em Saúde Pública, Escola Nacional de Saúde Pública, ENSP, CISP, Comprehensive Health Research Center, CHRC, Universidade NOVA de Lisboa, Lisbon, Portugal.
CIDNUR-Centro de Investigação, Inovação e Desenvolvimento Em Enfermagem de Lisboa Escola Superior de Enfermagem de Lisboa, Avenida Professor Egas Moniz, 1600-190, Lisbon, Portugal.

Maria João Forjaz (MJ)

National Center of Epidemiology, Instituto de Salud Carlos III, RICAPPS, Madrid, Spain.

Joël Coste (J)

Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France.

Laure Carcaillon-Bentata (L)

Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France.

Classifications MeSH