CIDE proteins and their regulatory mechanisms in lipid droplet fusion and growth.
CIDE
lipid droplet fusion
lipid transfer
phase separation
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
14 Feb 2024
14 Feb 2024
Historique:
revised:
19
12
2023
received:
28
10
2023
accepted:
04
01
2024
medline:
15
2
2024
pubmed:
15
2
2024
entrez:
14
2
2024
Statut:
aheadofprint
Résumé
The cell death-inducing DFF45-like effector (CIDE) proteins, including Cidea, Cideb, and Cidec/Fsp27, regulate various aspects of lipid homeostasis, including lipid storage, lipolysis, and lipid secretion. This review focuses on the physiological roles of CIDE proteins based on studies on knockout mouse models and human patients bearing CIDE mutations. The primary cellular function of CIDE proteins is to localize to lipid droplets (LDs) and to control LD fusion and growth across different cell types. We propose a four-step process of LD fusion, characterized by (a) the recruitment of CIDE proteins to the LD surface and CIDE movement, (b) the enrichment and condensate formation of CIDE proteins to form LD fusion plates at LD-LD contact sites, (c) lipid transfer through lipid-permeable passageways within the fusion plates, and (d) the completion of LD fusion. Lastly, we outline CIDE-interacting proteins as regulatory factors, as well as their contribution in LD fusion.
Identifiants
pubmed: 38355218
doi: 10.1002/1873-3468.14823
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Key Research and Development Program of China
ID : 2019YFA0801701
Organisme : National Key Research and Development Program of China
ID : 2022YFA0806502
Organisme : National Natural Science Foundation of China
ID : 32270724
Organisme : National Natural Science Foundation of China
ID : 92157107
Organisme : National Natural Science Foundation of China
ID : 92254308
Informations de copyright
© 2024 Federation of European Biochemical Societies.
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