Glaucoma as a cause of optic nerve abnormalities on magnetic resonance imaging.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
14 Feb 2024
14 Feb 2024
Historique:
received:
26
09
2023
accepted:
26
01
2024
revised:
12
01
2024
medline:
15
2
2024
pubmed:
15
2
2024
entrez:
14
2
2024
Statut:
aheadofprint
Résumé
To report a series of patients with glaucoma and optic nerve abnormalities on magnetic resonance imaging (MRI) in at least one-eye, and to determine whether these findings correlate with the severity of glaucoma. Retrospective study of all patients who underwent a brain/orbits MRI without and with contrast at our institution between 07/1/2019-6/30/2022. Patients with optic nerve T2-hyperintensity and/or MRI optic nerve atrophy in at least one-eye and a diagnosis of isolated glaucoma in at least one-eye were included. Demographic information, glaucoma clinical characteristics, glaucoma severity parameters, and MRI indication were collected. Fifty-six patients (112 eyes) (age 65 years-old [range 26-88]; 70% male) had isolated bilateral glaucoma with at least one-eye MRI optic nerve abnormality. The indication for MRI was atypical/asymmetric glaucoma in 91% of patients. Of the 112 eyes, 23 had optic nerve T2-hyperintensity alone; 33 had both optic nerve T2-hyperintensity and MRI optic nerve atrophy; 34 had MRI optic nerve atrophy alone; and 22 did not have abnormal optic nerve MRI-findings. None had optic nerve enhancement. A statistically significant association between optic nerve T2-hyperintensity or MRI optic nerve atrophy and glaucoma severity parameters was found. Glaucoma is a clinical diagnosis and MRI brain is usually not required, except in atypical or asymmetric cases. Optic nerve T2-hyperintensity and MRI optic nerve atrophy are nonspecific MRI-findings that can be found in severe glaucomatous optic nerves and should not systematically prompt investigations for another cause of optic neuropathy.
Sections du résumé
BACKGROUND/OBJECTIVES
OBJECTIVE
To report a series of patients with glaucoma and optic nerve abnormalities on magnetic resonance imaging (MRI) in at least one-eye, and to determine whether these findings correlate with the severity of glaucoma.
PATIENTS AND METHODS
METHODS
Retrospective study of all patients who underwent a brain/orbits MRI without and with contrast at our institution between 07/1/2019-6/30/2022. Patients with optic nerve T2-hyperintensity and/or MRI optic nerve atrophy in at least one-eye and a diagnosis of isolated glaucoma in at least one-eye were included. Demographic information, glaucoma clinical characteristics, glaucoma severity parameters, and MRI indication were collected.
RESULTS
RESULTS
Fifty-six patients (112 eyes) (age 65 years-old [range 26-88]; 70% male) had isolated bilateral glaucoma with at least one-eye MRI optic nerve abnormality. The indication for MRI was atypical/asymmetric glaucoma in 91% of patients. Of the 112 eyes, 23 had optic nerve T2-hyperintensity alone; 33 had both optic nerve T2-hyperintensity and MRI optic nerve atrophy; 34 had MRI optic nerve atrophy alone; and 22 did not have abnormal optic nerve MRI-findings. None had optic nerve enhancement. A statistically significant association between optic nerve T2-hyperintensity or MRI optic nerve atrophy and glaucoma severity parameters was found.
CONCLUSIONS
CONCLUSIONS
Glaucoma is a clinical diagnosis and MRI brain is usually not required, except in atypical or asymmetric cases. Optic nerve T2-hyperintensity and MRI optic nerve atrophy are nonspecific MRI-findings that can be found in severe glaucomatous optic nerves and should not systematically prompt investigations for another cause of optic neuropathy.
Identifiants
pubmed: 38355669
doi: 10.1038/s41433-024-02964-y
pii: 10.1038/s41433-024-02964-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
Références
Biousse V, Danesh-Meyer HV, Saindane AM, Lamirel C, Newman NJ. Imaging of the optic nerve: technological advances and future prospects. Lancet Neurol. 2022;21:1135–50.
doi: 10.1016/S1474-4422(22)00173-9
pubmed: 36155662
Costello F, Scott JN. Imaging in neuro-ophthalmology. Contin Lifelong Learn Neurol. 2019;25:1438–90.
doi: 10.1212/CON.0000000000000783
Labella Alvarez F, Mosleh R, Bouthour W, Saindane AM, Bruce BB, Dattilo M, et al. Optic nerve T2-hyperintensity: a nonspecific marker of optic nerve damage. J Neuroophthalmol. 2023;00:1–8.
Kosior-Jarecka E, Wróbel-Dudzińska D, Pietura R, Pankowska A, Szczuka B, Żarnowska I, et al. Results of neuroimaging in patients with atypical normal-tension glaucoma. Biomed Res Int. 2020;2020:9093206.
doi: 10.1155/2020/9093206
pubmed: 32908924
pmcid: 7450348
Kang L, Wan C. Application of advanced magnetic resonance imaging in glaucoma: a narrative review. Quant Imaging Med Surg. 2022;12:2106–28.
doi: 10.21037/qims-21-790
pubmed: 35284278
pmcid: 8899967
Mendoza M, Shotbolt M, Faiq MA, Parra C, Chan KC. Advanced diffusion MRI of the visual system in glaucoma: From experimental animal models to humans. Biology. 2022;11:454.
doi: 10.3390/biology11030454
pubmed: 35336827
pmcid: 8945790
Gracitelli CPB, Gerente VM, Furlanetto RL, Amaro E Jr, Paranhos A Jr. Magnetic resonance imaging for glaucoma evaluation. J Glaucoma. 2020;29:622–6.
doi: 10.1097/IJG.0000000000001558
pubmed: 32459691
Sartoretti T, Stürmer J, Sartoretti E, Najafi A, Schwenk Á, Wyss M, et al. Long segment 3D double inversion recovery (DIR) hypersignal on MRI in glaucomatous optic neuropathy. BMC Ophthalmol. 2019;19:1–7.
doi: 10.1186/s12886-019-1273-0
Nucci C, Aiello F, Giuliano M, Colosimo C, Mancino R. Ophthalmic segment of internal carotid artery aneurysm mimicking normal tension glaucoma. Int Ophthalmol. 2016;36:907–14.
doi: 10.1007/s10792-016-0206-7
pubmed: 26911718
Waisberg E, Micieli JA. Neuro-Ophthalmological optic nerve cupping: an overview. Eye Brain. 2021;13:255–68.
doi: 10.2147/EB.S272343
pubmed: 34934377
pmcid: 8684388
Lee JY, Kwon HJ, Park SJ, Yoo C, Kim YY, Kim EY. Signal alteration in the optic nerve head on 3D T2-weighted MRI: a potential neuroimaging sign of glaucomatous optic neuropathy. Curr Eye Res. 2018;43:397–405.
doi: 10.1080/02713683.2017.1399426
pubmed: 29120259
Ramli NM, Sidek S, Rahman FA, Peyman M, Zahari M, Rahmat K, et al. Novel use of 3T MRI in assessment of optic nerve volume in glaucoma. Graefe’s Arch Clin Exp Ophthalmol. 2014;252:995–1000.
doi: 10.1007/s00417-014-2622-6
Zhang YQ, Li J, Xu L, Zhang L, Wang ZC, Yang H, et al. Anterior visual pathway assessment by magnetic resonance imaging in normal‐pressure glaucoma. Acta Ophthalmol. 2012;90:e295–e302.
doi: 10.1111/j.1755-3768.2011.02346.x
pubmed: 22489916
Lagrèze WA, Gaggl M, Weigel M, Schulte-Mönting J, Bühler A, Bach M, et al. Retrobulbar optic nerve diameter measured by high-speed magnetic resonance imaging as a biomarker for axonal loss in glaucomatous optic atrophy. Invest Ophthalmol Vis Sci. 2009;50:4223–8.
doi: 10.1167/iovs.08-2683
pubmed: 19407026
Kashiwagi K, Okubo T, Tsukahara S. Association of magnetic resonance imaging of anterior optic pathway with glaucomatous visual field damage and optic disc cupping. J Glaucoma. 2004;13:189–95.
doi: 10.1097/00061198-200406000-00003
pubmed: 15118461
Weber AJ, Chen H, Hubbard WC, Kaufman PL. Invest Ophthalmol Vis Sci. 2000;41:1370–9.
pubmed: 10798652
Gupta N, Ang LC, Noël de Tilly L, Bidaisee L, Yücel YH. Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol. 2006;90:674–8.
doi: 10.1136/bjo.2005.086769
pubmed: 16464969
pmcid: 1860237
Jonas JB, Schmidt AM, Müller-Bergh JA, Naumann GO. Optic nerve fiber count and diameter of the retrobulbar optic nerve in normal and glaucomatous eyes. Graefes Arch Clin Exp Ophthalmol. 1995;233:421–4.
doi: 10.1007/BF00180945
pubmed: 7557506
Ersoz MG, Pekcevik Y, Ayintap E, Gunes İB, Mart DK, Yucel E, et al. Curr Eye Res. 2017;42:995–1001.
doi: 10.1080/02713683.2017.1279633
pubmed: 28632031
Mashima Y, Oshitari K, Imamura Y, Momoshima S, Shiga H, Oguchi Y. High-resolution magnetic resonance imaging of the intraorbital optic nerve and subarachnoid space in patients with papilledema and optic atrophy. Arch Ophthalmol. 1996;114:1197–203.
doi: 10.1001/archopht.1996.01100140397006
pubmed: 8859078
Tourbah A. Contribution of imaging to the diagnosis of optic neuropathies. Rev Neurol. 2012;168:702–5.
doi: 10.1016/j.neurol.2012.07.012
pubmed: 22981271
Iba-Zizen MT, Istoc A, Cabanis EA. The results of MRI exploration of glaucoma patients: what are the benefits? J Fr Ophtalmol. 2008;31:2S24–2S28.
pubmed: 18957909
DeBusk A, Subramanian PS, Scannell Bryan M, Moster ML, Calvert PC, Frohman LP. Mismatch in supply and demand for neuro-ophthalmic care. J Neuroophthalmol. 2022;42:62–67.
doi: 10.1097/WNO.0000000000001214
pubmed: 33770009
Frohman LP. The human resource crisis in neuro-ophthalmology. J Neuroophthalmol. 2008;28:231–4.
doi: 10.1097/WNO.0b013e318185e084
pubmed: 18769291
Celebi AR, Mirza GE. Age-related change in retinal nerve fiber layer thickness measured with spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2013;54:8095–103.
doi: 10.1167/iovs.13-12634
pubmed: 24194190
Parikh RS, Parikh SR, Sekhar GC, Prabakaran S, Babu JG, Thomas R. Normal age-related decay of retinal nerve fiber layer thickness. Ophthalmology. 2007;114:921–6.
doi: 10.1016/j.ophtha.2007.01.023
pubmed: 17467529
Leung CK, Yu M, Weinreb RN, Ye C, Liu S, Lai G, et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss. Ophthalmology. 2012;119:731–7.
doi: 10.1016/j.ophtha.2011.10.010
pubmed: 22264886