Arboviruses and pregnancy: are the threats visible or hidden?

Arboviruses Dengue fever Disease outbreaks Fetal outcomes Fever Maternal Mosquito-borne flavivirus Pregnancy West Nile virus Zika virus

Journal

Tropical diseases, travel medicine and vaccines
ISSN: 2055-0936
Titre abrégé: Trop Dis Travel Med Vaccines
Pays: England
ID NLM: 101674442

Informations de publication

Date de publication:
15 Feb 2024
Historique:
received: 25 09 2023
accepted: 22 11 2023
medline: 15 2 2024
pubmed: 15 2 2024
entrez: 15 2 2024
Statut: epublish

Résumé

Mosquito-borne arboviral diseases are a global concern and can have severe consequences on maternal, neonatal, and child health. Their impact on pregnancy tends to be neglected in developing countries. Despite hundreds of millions of infections, 90% pregnancies being exposed, scientific data on pregnant women is poor and sometimes non-existent. Recently and since the 2016 Zika virus outbreak, there has been a newfound interest in these diseases. Through various neuropathogenic, visceral, placental, and teratogenic mechanisms, these arbovirus infections can lead to fetal losses, obstetrical complications, and a wide range of congenital abnormalities, resulting in long-term neurological and sensory impairments. Climate change, growing urbanization, worldwide interconnectivity, and ease of mobility allow arboviruses to spread to other territories and impact populations that had never been in contact with these emerging agents before. Pregnant travelers are also at risk of infection with potential subsequent complications. Beyond that, these pathologies show the inequalities of access to care on a global scale in a context of demographic growth and increasing urbanization. It is essential to promote research, diagnostic tools, treatments, and vaccine development to address this emerging threat.Background The vulnerability of pregnant women and fetuses to emergent and re-emergent pathogens has been notably illustrated by the outbreaks of Zika virus. Our comprehension of the complete scope and consequences of these infections during pregnancy remains limited, particularly among those involved in perinatal healthcare, such as obstetricians and midwives. This review aims to provide the latest information and recommendations regarding the various risks, management, and prevention for pregnant women exposed to arboviral infections.

Identifiants

pubmed: 38355934
doi: 10.1186/s40794-023-00213-w
pii: 10.1186/s40794-023-00213-w
doi:

Types de publication

Journal Article

Langues

eng

Pagination

4

Informations de copyright

© 2024. The Author(s).

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Auteurs

Najeh Hcini (N)

Department of Obstetrics and Gynecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana. n.hcini@ch-ouestguyane.fr.
CIC Inserm 1424 and DFR Santé Université Guyane, Cayenne, French Guiana, France. n.hcini@ch-ouestguyane.fr.

Véronique Lambert (V)

Department of Obstetrics and Gynecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.

Olivier Picone (O)

Department of Obstetrics and Gynecology, Hôpital Louis Mourier, Hôpitaux Universitaires Paris Nord Val de Seine, Assistance Publique : Hôpitaux de Paris, Université Paris Diderot, CEDEX, Colombes, France.

Jean-Francois Carod (JF)

Department of Biology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.

Gabriel Carles (G)

Department of Obstetrics and Gynecology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni, French Guiana.

Léo Pomar (L)

Materno-Fetal and Obstetrics Research Unit, Department "Woman-Mother-Child", Lausanne University Hospital, Lausanne, Switzerland.

Loïc Epelboin (L)

Department of Infectious and Tropical Diseases, Cayenne General Hospital, Cayenne, French Guiana, France.

Mathieu Nacher (M)

Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.

Classifications MeSH