Feline high-grade and large granular lymphocyte alimentary lymphomas treated with COP- or CHOP-based chemotherapy: A multi-centric retrospective study of 57 cases.
cat
chemotherapy
gastrointestinal tract
lymphoma
Journal
Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242
Informations de publication
Date de publication:
14 Feb 2024
14 Feb 2024
Historique:
revised:
22
01
2024
received:
03
10
2023
accepted:
24
01
2024
medline:
15
2
2024
pubmed:
15
2
2024
entrez:
15
2
2024
Statut:
aheadofprint
Résumé
Specific data regarding outcome of cats with high-grade and large granular lymphocyte alimentary lymphoma (HGAL and LGL, respectively) treated with multi-agent chemotherapy are scarce. The aims of this multi-centric, retrospective study were to describe the outcome of cats with HGAL and LGL treated with COP- or CHOP-based chemotherapy and to identify potential prognostic factors. Cats with a cytological or histological diagnosis of HGAL or LGL lymphoma treated with COP- or CHOP-based protocol as first-line chemotherapy were included. Data regarding diagnosis, staging, treatment and follow-up were collected. Fifty-seven cats treated with CHOP (n = 37) or COP (n = 20) protocols were included. Complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD) were observed in 20%, 22%, 36% and 22% of cats, respectively, for an overall response rate of 42%. Median progression-free interval (PFI) was 148 days and overall median survival time (OST) was 131 days. Cats achieving CR, PR or SD showed significantly longer PFI (p < .01) and OST (p < .015) compared with cats with PD. Other positive prognostic factors in multi-variate analysis were rescue treatment (p < .001) and absence of lymph node involvement (p < .03). Negative prognostic factors were diffuse infiltration of the gastrointestinal tract (p = .035) and infiltration of a non-haematopoietic organ (p < .01).
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd.
Références
Hardy WDJ. Hematopoietic tumors of cats. Am Anim Hosp Assoc. 1981;17:921-940.
Essex M, Francis DP. The risk to humans from malignant diseases of their pets: an unsettled issue [zoonoses]. Am Anim Hosp Assoc. 1976;12:386-390.
Theilen GH, Madewell BR. Feline hematopoietic neoplasms. In: Theilen GHMB, eds. Veterinary Cancer Medicine. 2nd ed. Philadelphia. Lea & Febiger; 1987.
Manuali E, Forte C, Vichi G, et al. Tumours in European shorthair cats: a retrospective study of 680 cases. J Feline Med Surg. 2020;22(12):1095-1102.
Economu L, Stell A, O'Neill DG, Schofield I, Stevens K, Brodbelt D. Incidence and risk factors for feline lymphoma in UK primary-care practice. J Small Anim Pract. 2021;62(2):97-106.
Waite AHK, Jackson K, Gregor TP, Krick EL. Lymphoma in cats treated with a weekly cyclophosphamide-, vincristine-, and prednisone-based protocol: 114 cases (1998-2008). J Am Vet Med Assoc. 2013;242(8):1104-1109.
Collette SA, Allstadt SD, Chon EM, et al. Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012). Vet Comp Oncol. 2016;14 Suppl 1(Suppl 1):136-146.
Mooney SC, Hayes AA, MacEwen EG, Matus RE, Geary A, Shurgot BA. Treatment and prognostic factors in lymphoma in cats: 103 cases (1977-1981). J Am Vet Med Assoc. 1989;194(5):696-702.
Milner RJ, Peyton J, Cooke K, et al. Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol: 38 cases (1996-2003). J Am Vet Med Assoc. 2005;227(7):1118-1122.
Barrs VR, Beatty JA. Feline alimentary lymphoma: 1. Classification, risk factors, clinical signs and non-invasive diagnostics. J Feline Med Surg. 2012;14(3):182-190.
Rissetto K, Villamil JA, Selting KA, Tyler J, Henry CJ. Recent trends in feline intestinal neoplasia: an epidemiologic study of 1,129 cases in the veterinary medical database from 1964 to 2004. J Am Anim Hosp Assoc. 2011;47(1):28-36.
Moore PF, Rodriguez-Bertos A, Kass PH. Feline gastrointestinal lymphoma: mucosal architecture, immunophenotype, and molecular clonality. Vet Pathol. 2012;49(4):658-668.
Mahony OM, Moore AS, Cotter SM, Engler SJ, Brown D, Penninck DG. Alimentary lymphoma in cats: 28 cases (1988-1993). J Am Vet Med Assoc. 1995;207(12):1593-1598.
Gieger T. Alimentary lymphoma in cats and dogs. Vet Clin North Am Small Anim Pract. 2011;41(2):419-432.
Fondacaro JV, Richter K, Carpenter J, Hart JR, Hill S, Fettman MJ. Feline gastrointestinal lymphoma: 67 cases (1988-1996). Eur J Comp Gastroenterol. 1999;4:199.
Barrs VR, Beatty JA. Feline alimentary lymphoma: 2. Further diagnostics, therapy and prognosis. J Feline Med Surg. 2012;14(3):191-201.
Finotello R, Vasconi ME, Sabattini S, et al. Feline large granular lymphocyte lymphoma: an Italian Society of Veterinary Oncology (SIONCOV) retrospective study. Vet Comp Oncol. 2018;16(1):159-166.
Vail DM, Pinkerton M. Feline lymphoma and leukemia. In: Vail DM, Thamm DH, Liptak JM, eds. Withrow & MacEwen's Small Animal Clinical Oncology. Sixth ed. Saunders Elsevier; 2020:715-730 Chapter 33. Section B.
Moore AS, Cotter SM, Frimberger AE, Wood CA, Rand WM, L'Heureux DA. A comparison of doxorubicin and COP for maintenance of remission in cats with lymphoma. J Vet Intern Med. 1996;10(6):372-375.
Gustafson TL, Villamil A, Taylor BE, Flory A. A retrospective study of feline gastric lymphoma in 16 chemotherapy-treated cats. J Am Anim Hosp Assoc. 2014;50(1):46-52.
Gouldin ED, Mullin C, Morges M, et al. Feline discrete high-grade gastrointestinal lymphoma treated with surgical resection and adjuvant CHOP-based chemotherapy: retrospective study of 20 cases. Vet Comp Oncol. 2017;15(2):328-335.
Limmer S, Eberle N, Nerschbach V, Nolte I, Betz D. Treatment of feline lymphoma using a 12-week, maintenance-free combination chemotherapy protocol in 26 cats. Vet Comp Oncol. 2016;14(Suppl 1):21-31.
Simon D, Eberle N, Laacke-Singer L, Nolte I. Combination chemotherapy in feline lymphoma: treatment outcome, tolerability, and duration in 23 cats. J Vet Intern Med. 2008;22(2):394-400.
Hadden AG, Cotter SM, Rand W, Moore AS, Davis RM, Morrissey P. Efficacy and toxicosis of VELCAP-C treatment of lymphoma in cats. J Vet Intern Med. 2008;22(1):153-157.
Jeglum KA, Whereat A, Young K. Chemotherapy of lymphoma in 75 cats. J Am Vet Med Assoc. 1987;190(2):174-178.
Vail DM, Moore AS, Ogilvie GK, Volk LM. Feline lymphoma (145 cases): proliferation indices, cluster of differentiation 3 immunoreactivity, and their association with prognosis in 90 cats. J Vet Intern Med. 1998;12(5):349-354.
Krupa A, de Vos J, Van Eetvelde L, Teske E. Pegylated asparaginase in feline high-grade lymphoma: clinical results of single injection and continued incorporation into a modified COP regimen. J Feline Med Surg. 2022;24(8):e203-e213.
Krick EL, Cohen RB, Gregor TP, Salah PC, Sorenmo K. Prospective clinical trial to compare vincristine and vinblastine in a COP-based protocol for lymphoma in cats. J Vet Intern Med. 2013;27(1):134-140.
Tidd KS, Durham AC, Brown DC, Velovolu S, Nagel J, Krick EL. Outcomes in 40 cats with discrete intermediate- or large-cell gastrointestinal lymphoma masses treated with surgical mass resection (2005-2015). Vet Surg. 2019;48(7):1218-1228.
Sapierzyński R, Jankowska U, Jagielski D, Kliczkowska-Klarowicz K. Large granular lymphoma in six cats. Pol J Vet Sci. 2015;18(1):163-169.
Krick EL, Little L, Patel R, et al. Description of clinical and pathological findings, treatment and outcome of feline large granular lymphocyte lymphoma (1996-2004). Vet Comp Oncol. 2008;6(2):102-110.
LeBlanc AK, Atherton M, Bentley RT, et al. Veterinary cooperative oncology group-common terminology criteria for adverse events (VCOG-CTCAE v2) following investigational therapy in dogs and cats. Vet Comp Oncol. 2021;19(2):311-352.
Nguyen SM, Thamm DH, Vail DM, London CA. Response evaluation criteria for solid tumours in dogs (v1.0): a veterinary cooperative oncology group (VCOG) consensus document. Vet Comp Oncol. 2015;13(3):176-183.
Rau SE, Burgess KE. A retrospective evaluation of lomustine (CeeNU) in 32 treatment naïve cats with intermediate to large cell gastrointestinal lymphoma (2006-2013). Vet Comp Oncol. 2017;15(3):1019-1028.
Zwahlen CH, Lucroy MD, Kraegel SA, Madewell BR. Results of chemotherapy for cats with alimentary malignant lymphoma: 21 cases (1993-1997). J Am Vet Med Assoc. 1998;213(8):1144-1149.
Teske E, van Straten G, van Noort R, Rutteman GR. Chemotherapy with cyclophosphamide, vincristine, and prednisolone (COP) in cats with malignant lymphoma: new results with an old protocol. J Vet Intern Med. 2002;16(2):179-186.
Williams AG, Hohenhaus AE, Lamb KE. Incidence and treatment of feline renal lymphoma: 27 cases. J Feline Med Surg. 2021;23(10):936-944.
Roccabianca P, Vernau W, Caniatti M, Moore PF. Feline large granular lymphocyte (LGL) lymphoma with secondary leukemia: primary intestinal origin with predominance of a CD3/CD8(alpha)(alpha) phenotype. Vet Pathol. 2006;43(1):15-28.
Rahul E, Ningombam A, Acharya S, Tanwar P, Ranjan A, Chopra A. Large granular lymphocytic leukemia: a brief review. Am J Blood Res. 2022;12(1):17-32.
Macon WR, Williams ME, Greer JP, et al. Natural killer-like T-cell lymphomas: aggressive lymphomas of T-large granular lymphocytes. Blood. 1996;87(4):1474-1483.