Multi-scale

3D printing Raman spectroscopy cochlear implant compression finite element analysis mechanical characterization stereolithography two-photon polymerization

Journal

Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513

Informations de publication

Date de publication:
2023
Historique:
received: 05 09 2023
accepted: 27 11 2023
medline: 15 2 2024
pubmed: 15 2 2024
entrez: 15 2 2024
Statut: epublish

Résumé

The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects. Cochlear implants offer a potential solution by providing localized and sustained drug delivery to the cochlea. While the mechanical characterization of both the implants and their constituent material is crucial to ensure functional performance and structural integrity during implantation, this aspect has been mostly overlooked. This study proposes a novel methodology for the mechanical characterization of our recently developed cochlear implant design, namely, rectangular and cylindrical, fabricated using two-photon polymerization (2 PP) with a novel photosensitive resin (IP-Q™). We used

Identifiants

DOI: 10.3389/fbioe.2023.1289299 PMID: 38356932 PMC: PMC10865239
pubmed: 38356932
doi: 10.3389/fbioe.2023.1289299
pii: 1289299
pmc: PMC10865239
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1289299

Informations de copyright

Copyright © 2024 Isaakidou, Ganjian, van Hoften, Saldivar, Leeflang, Groetsch, Wątroba, Schwiedrzik, Mirzaali, Apachitei, Fratila-Apachitei and Zadpoor.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

A Isaakidou (A)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

M Ganjian (M)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

R van Hoften (R)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

M C Saldivar (MC)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

M A Leeflang (MA)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

A Groetsch (A)

Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory of Mechanics of Materials and Nanostructures, Thun, Switzerland.
Department of Materials Science and Engineering, Henry Samueli School of Engineering, University of California, Irvine, Irvine, CA, United States.

M Wątroba (M)

Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory of Mechanics of Materials and Nanostructures, Thun, Switzerland.

J Schwiedrzik (J)

Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory of Mechanics of Materials and Nanostructures, Thun, Switzerland.

M J Mirzaali (MJ)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

I Apachitei (I)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

L E Fratila-Apachitei (LE)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

A A Zadpoor (AA)

Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology (TU Delft), Delft, Netherlands.

Classifications MeSH