No-reflow after stroke reperfusion therapy: An emerging phenomenon to be explored.
acute ischemic stroke
endovascular thrombectomy
microvascular disturbance
no-reflow phenomenon
reperfusion therapy
Journal
CNS neuroscience & therapeutics
ISSN: 1755-5949
Titre abrégé: CNS Neurosci Ther
Pays: England
ID NLM: 101473265
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
revised:
02
01
2024
received:
27
06
2023
accepted:
21
01
2024
medline:
15
2
2024
pubmed:
15
2
2024
entrez:
15
2
2024
Statut:
ppublish
Résumé
In the field of stroke thrombectomy, ineffective clinical and angiographic reperfusion after successful recanalization has drawn attention. Partial or complete microcirculatory reperfusion failure after the achievement of full patency of a former obstructed large vessel, known as the "no-reflow phenomenon" or "microvascular obstruction," was first reported in the 1960s and was later detected in both experimental models and patients with stroke. The no-reflow phenomenon (NRP) was reported to result from intraluminal occlusions formed by blood components and extraluminal constriction exerted by the surrounding structures of the vessel wall. More recently, an emerging number of clinical studies have estimated the prevalence of the NRP in stroke patients following reperfusion therapy, ranging from 3.3% to 63% depending on its evaluation methods or study population. Studies also demonstrated its detrimental effects on infarction progress and neurological outcomes. In this review, we discuss the research advances, underlying pathogenesis, diagnostic techniques, and management approaches concerning the no-reflow phenomenon in the stroke population to provide a comprehensive understanding of this phenomenon and offer references for future investigations.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14631Subventions
Organisme : Beijing Natural Science Foundation
ID : JQ22020
Organisme : Beijing Nova Program
ID : Z201100006820143
Organisme : National Natural Science Foundation of China
ID : 81801313
Organisme : National Natural Science Foundation of China
ID : 82001257
Organisme : National Natural Science Foundation of China
ID : 81971114
Informations de copyright
© 2024 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.
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