A PDZ scaffolding/CaM-mediated pathway in Cryptochrome signaling.
Calmodulin
MUPP1
circadian rhythms
cryptochrome signaling
hCRY2
Journal
Protein science : a publication of the Protein Society
ISSN: 1469-896X
Titre abrégé: Protein Sci
Pays: United States
ID NLM: 9211750
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
12
12
2023
received:
24
08
2023
accepted:
13
01
2024
medline:
15
2
2024
pubmed:
15
2
2024
entrez:
15
2
2024
Statut:
ppublish
Résumé
Cryptochromes are cardinal constituents of the circadian clock, which orchestrates daily physiological rhythms in living organisms. A growing body of evidence points to their participation in pathways that have not traditionally been associated with circadian clock regulation, implying that cryptochromes may be subject to modulation by multiple signaling mechanisms. In this study, we demonstrate that human CRY2 (hCRY2) forms a complex with the large, modular scaffolding protein known as Multi-PDZ Domain Protein 1 (MUPP1). This interaction is facilitated by the calcium-binding protein Calmodulin (CaM) in a calcium-dependent manner. Our findings suggest a novel cooperative mechanism for the regulation of mammalian cryptochromes, mediated by calcium ions (Ca
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e4914Subventions
Organisme : Università degli Studi di Padova (P-DiSC)
ID : BIRD213814/21
Organisme : Università degli Studi di Padova (P-DiSC)
ID : 01BIRD2018
Organisme : Fondazione Cassa di Risparmio di Padova e Rovigo (Progetti di Eccellenza 2011-2012)
Organisme : National Research Council of Italy
Organisme : Ministero dell'Istruzione, dell'Universitá e della Ricerca (MIUR)
Organisme : INsecTIME FP7 People: Marie-Curie Actions Initial Training Network
ID : PITN-GA-2012-316790
Informations de copyright
© 2024 The Protein Society.
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