Melatonin Modulates Cell Cycle Dynamics and Promotes Hippocampal Cell Proliferation After Ischemic Injury in Neonatal Rats.

Cell cycle Flow cytometry Melatonin Neonatal ischemia Proliferation

Journal

Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963

Informations de publication

Date de publication:
15 Feb 2024
Historique:
received: 04 08 2023
accepted: 31 01 2024
medline: 15 2 2024
pubmed: 15 2 2024
entrez: 15 2 2024
Statut: aheadofprint

Résumé

Promoting neural cell proliferation may represent an important strategy for enhancing brain repair after developmental brain injury. The present study aimed to assess the effects of melatonin on cell proliferation after an ischemic injury in the developing hippocampus, focusing on cell cycle dynamics. After in vivo neonatal hypoxia-ischemia (HI), hippocampal cell cycle dynamics were assessed by flow cytometry, together with histological evaluation of dentate gyrus cellularity and proliferation. Melatonin significantly increased the number of proliferating cells in the G2/M phase as well as the proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) labeling reduced by HI. In vivo BrdU labeling revealed a higher BrdU-positivity in the dentate gyrus of ischemic rats treated with melatonin, an effect followed by increased cellularity and preserved hippocampal tissue integrity. These results indicate that the protective effect of melatonin after ischemic injury in neonatal rats may rely on the modulation of cell cycle dynamics of newborn hippocampal cells and increased cell proliferation.

Identifiants

pubmed: 38358438
doi: 10.1007/s12035-024-04013-x
pii: 10.1007/s12035-024-04013-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Università degli Studi di Urbino Carlo Bo
ID : DR-473_2018
Organisme : EITB Maratoia-BIOEF
ID : BIO18/IC/003

Informations de copyright

© 2024. The Author(s).

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Auteurs

Barbara Canonico (B)

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via S. Chiara 27, 61029, Urbino, PU, Italy.

Silvia Carloni (S)

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via S. Chiara 27, 61029, Urbino, PU, Italy.

Mariele Montanari (M)

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via S. Chiara 27, 61029, Urbino, PU, Italy.

Patrizia Ambrogini (P)

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via S. Chiara 27, 61029, Urbino, PU, Italy.

Stefano Papa (S)

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via S. Chiara 27, 61029, Urbino, PU, Italy.

Daniel Alonso-Alconada (D)

Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain. daniel.alonsoa@ehu.eus.

Walter Balduini (W)

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via S. Chiara 27, 61029, Urbino, PU, Italy. walter.balduini@uniurb.it.

Classifications MeSH