A potent candicidal peptide designed based on an encrypted peptide from a proteinase inhibitor.
Antifungal agents
Antimicrobial peptides
Candidiasis
Peptide-based drugs
Journal
Biochimica et biophysica acta. General subjects
ISSN: 1872-8006
Titre abrégé: Biochim Biophys Acta Gen Subj
Pays: Netherlands
ID NLM: 101731726
Informations de publication
Date de publication:
13 Feb 2024
13 Feb 2024
Historique:
received:
04
08
2023
revised:
23
01
2024
accepted:
12
02
2024
medline:
16
2
2024
pubmed:
16
2
2024
entrez:
15
2
2024
Statut:
aheadofprint
Résumé
Antimicrobial peptides (AMP) represent an alternative in the treatment of fungal infections associated with countless deaths. Here, we report a new AMP, named KWI-19, which was designed based on a peptide encrypted in the sequence of an Inga laurina Kunitz-type inhibitor (ILTI). KWI-19 inhibited the growth of Candida species and acted as a fungicidal agent from 2.5 to 20 μmol L
Identifiants
pubmed: 38360076
pii: S0304-4165(24)00026-6
doi: 10.1016/j.bbagen.2024.130583
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
130583Informations de copyright
Copyright © 2023. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no competing interests or personal relationships that could have appeared to influence the work reported in this paper.