The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma.

Early stage Large nuclei Oral tongue cancer Single cell invasion Survival

Journal

BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800

Informations de publication

Date de publication:
15 Feb 2024
Historique:
received: 06 10 2023
accepted: 05 02 2024
medline: 16 2 2024
pubmed: 16 2 2024
entrez: 15 2 2024
Statut: epublish

Résumé

The clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC). We used hematoxylin and eosin-stained sections to evaluate the presence of single cell invasion and large nuclei in a multicenter cohort of 311 cases treated for early-stage OTSCC. Single cell invasion was associated in multivariable analysis with poor disease-specific survival (DSS) with a hazard ratio (HR) of 2.089 (95% CI 1.224-3.566, P = 0.007), as well as with disease-free survival (DFS) with a HR of 1.666 (95% CI 1.080-2.571, P = 0.021). Furthermore, large nuclei were associated with worse DSS (HR 2.070, 95% CI 1.216-3.523, P = 0.007) and with DFS in multivariable analysis (HR 1.645, 95% CI 1.067-2.538, P = 0.024). Single cell invasion and large nuclei can be utilized for classifying early OTSCC into risk groups.

Sections du résumé

BACKGROUND BACKGROUND
The clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC).
METHODS METHODS
We used hematoxylin and eosin-stained sections to evaluate the presence of single cell invasion and large nuclei in a multicenter cohort of 311 cases treated for early-stage OTSCC.
RESULTS RESULTS
Single cell invasion was associated in multivariable analysis with poor disease-specific survival (DSS) with a hazard ratio (HR) of 2.089 (95% CI 1.224-3.566, P = 0.007), as well as with disease-free survival (DFS) with a HR of 1.666 (95% CI 1.080-2.571, P = 0.021). Furthermore, large nuclei were associated with worse DSS (HR 2.070, 95% CI 1.216-3.523, P = 0.007) and with DFS in multivariable analysis (HR 1.645, 95% CI 1.067-2.538, P = 0.024).
CONCLUSION CONCLUSIONS
Single cell invasion and large nuclei can be utilized for classifying early OTSCC into risk groups.

Identifiants

DOI: 10.1186/s12885-024-11954-y PMID: 38360653
pubmed: 38360653
doi: 10.1186/s12885-024-11954-y
pii: 10.1186/s12885-024-11954-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

213

Informations de copyright

© 2024. The Author(s).

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Auteurs

Alhadi Almangush (A)

Department of Pathology, University of Helsinki, FI-00014, Helsinki, Haartmaninkatu, P.O. Box 21, Finland. alhadi.almangush@helsinki.fi.
Institute of Biomedicine, Pathology, University of Turku, Turku, Finland. alhadi.almangush@helsinki.fi.
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. alhadi.almangush@helsinki.fi.
Faculty of Dentistry, Misurata University, Misurata, Libya. alhadi.almangush@helsinki.fi.

Jaana Hagström (J)

Department of Pathology, University of Helsinki, FI-00014, Helsinki, Haartmaninkatu, P.O. Box 21, Finland.
Research Programs Unit, Translational Cancer Medicine, University of Helsinki, 00014, Helsinki, P.O. Box 63, Finland.
Department of Oral Pathology and Radiology, University of Turku, Turku, Finland.

Caj Haglund (C)

Research Programs Unit, Translational Cancer Medicine, University of Helsinki, 00014, Helsinki, P.O. Box 63, Finland.
Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Luiz Paulo Kowalski (LP)

Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, Department of Head and Neck Surgery, University of Sao Paulo Medical School, 05402-000, São Paulo, SP, Brazil.

Ricardo D Coletta (RD)

Department of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, 13414-018, Piracicaba, São Paulo, Brazil.

Antti A Mäkitie (AA)

Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Department of Otorhinolaryngology- Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, FI-00029 HUS, Helsinki, P.O. Box 263, Finland.
Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Tuula Salo (T)

Department of Pathology, University of Helsinki, FI-00014, Helsinki, Haartmaninkatu, P.O. Box 21, Finland.
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.

Ilmo Leivo (I)

Institute of Biomedicine, Pathology, University of Turku, Turku University Central Hospital, 20520, Turku, Finland.

Classifications MeSH