Panicolytic-like effects of environment enrichment on male mice threatened by Bothrops jararaca lancehead pit vipers.
Bothrops jararaca lancehead pit vipers
anxiety
enriched environment
enriched polygonal arena for snake panic test
panic attacks
unconditioned fear
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
revised:
01
12
2023
received:
19
04
2023
accepted:
16
01
2024
medline:
16
2
2024
pubmed:
16
2
2024
entrez:
16
2
2024
Statut:
ppublish
Résumé
Environment enrichment (EE) is a well-known eustress model showing beneficial effects in different psychiatric diseases, but its positive properties in panic disorders are not yet established. The confrontation between prey and predator in complex arenas has been validated as a putative panic attack model. The principal aim of this work was to investigate the role of the EE on panic-like defensive responses elicited by mice threatened by venomous snakes. After 6 weeks of exposure either to an enriched or standard environments, 36 male mice were habituated in a complex polygonal arena for snakes containing an artificial burrow and elevated platforms for escape. The animals were confronted by Bothrops jararaca for 5 min, and the following antipredatory responses were recorded: defensive attention, stretched attend posture, flat back approach, prey versus predator interaction, oriented escape behavior, time spent in a safe place, and number of crossings. Mice threatened by snakes displayed several antipredatory reactions as compared to the exploratory behavior of those animals submitted to a nonthreatening situation (toy snake) in the same environment. Notably, EE causes anxiolytic- and panicolytic-like effects significantly decreasing the defensive attention and time spent in safe places and significantly increasing both prey versus predator interaction and exploratory behavior. In conclusion, our data demonstrate that EE can alter the processing of fear modulation regarding both anxiety- and panic-like responses in a dangerous condition, significantly modifying the decision-making defensive strategy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25300Subventions
Organisme : Pro-Rectory of the University of São Paulo
Organisme : Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico
Organisme : Fundação de Apoio ao Ensino, Pesquisa e Assistência do HC-FMRP-USP
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
Informations de copyright
© 2024 Wiley Periodicals LLC.
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