Clonal Expansion in Cardiovascular Pathology.
cardiovascular diseases
clonal expansion
endothelial cells
macrophages
vascular smooth muscle cells
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
03
02
2023
revised:
13
04
2023
accepted:
14
04
2023
medline:
16
2
2024
pubmed:
16
2
2024
entrez:
16
2
2024
Statut:
epublish
Résumé
Clonal expansion refers to the proliferation and selection of advantageous "clones" that are better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced our understanding of cell clonality in the cardiovascular context. However, our knowledge of the underlying mechanisms behind this clonal selection is still severely limited. There is a transpiring pattern of clonal expansion of smooth muscle cells and endothelial cells-and, in some cases, macrophages-in numerous cardiovascular diseases irrespective of their differing microenvironments. These findings indirectly suggest the possible existence of stem-like vascular cells which are primed to respond during disease. Subsequent clones may undergo further phenotypic changes to adopt either protective or detrimental roles. By investigating these clone-forming vascular cells, we may be able to harness this inherent clonal nature for future therapeutic intervention. This review comprehensively discusses what is currently known about clonal expansion across the cardiovascular field. Comparisons of the clonal nature of vascular cells in atherosclerosis (including clonal hematopoiesis of indeterminate potential), pulmonary hypertension, aneurysm, blood vessel injury, ischemia- and tumor-induced angiogenesis, and cerebral cavernous malformations are evaluated. Finally, we discuss the potential clinical implications of these findings and propose that proper understanding and specific targeting of these clonal cells may provide unique therapeutic options for the treatment of these cardiovascular conditions.
Identifiants
pubmed: 38362345
doi: 10.1016/j.jacbts.2023.04.008
pii: S2452-302X(23)00196-1
pmc: PMC10864919
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
120-144Subventions
Organisme : British Heart Foundation
ID : RG/20/5/34796
Pays : United Kingdom
Informations de copyright
© 2024 The Authors.
Déclaration de conflit d'intérêts
Mr Lin is supported by an Australian Government Research Training Program (RTP) Scholarship. Drs Baker, Sluimer, and MIsra are supported by an Heart Research Institute (HRI-UK) Grant.
Références
Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2699-706
pubmed: 17951320
Annu Rev Pharmacol Toxicol. 1995;35:235-55
pubmed: 7598493
Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):603-612
pubmed: 30727757
Circ Res. 2016 Jul 22;119(3):404-6
pubmed: 27458193
Am J Pathol. 1975 Nov;81(2):379-87
pubmed: 1190295
J Am Heart Assoc. 2022 Apr 5;11(7):e023021
pubmed: 35348002
J Clin Invest. 1998 Mar 1;101(5):927-34
pubmed: 9486960
Am J Respir Crit Care Med. 1998 Dec;158(6):1999-2001
pubmed: 9847298
Am J Pathol. 2010 Feb;176(2):952-67
pubmed: 20042677
Cell Tissue Res. 2017 Mar;367(3):643-649
pubmed: 28025704
Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12640-5
pubmed: 20616044
Cell Discov. 2021 Sep 28;7(1):88
pubmed: 34580277
Neuron. 2014 Feb 5;81(3):505-20
pubmed: 24507188
Lancet. 2005 Apr 30-May 6;365(9470):1577-89
pubmed: 15866312
Genesis. 2009 Jan;47(1):14-8
pubmed: 18942088
Cardiovasc Res. 2018 Mar 15;114(4):540-550
pubmed: 29385543
Clin Exp Immunol. 2000 Aug;121(2):255-60
pubmed: 10931139
Circ Res. 2018 May 25;122(11):1608-1624
pubmed: 29798903
Heart. 2011 Feb;97(3):181-9
pubmed: 20884790
Nature. 2012 Apr 25;484(7395):479-84
pubmed: 22538609
Circulation. 2020 Nov 24;142(21):2045-2059
pubmed: 32674599
J Appl Physiol (1985). 2003 Nov;95(5):2081-8
pubmed: 12857765
Nature. 2007 Nov 1;450(7166):56-62
pubmed: 17972876
Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14476-81
pubmed: 10588730
Stroke. 2015 May;46(5):1337-43
pubmed: 25791711
Circulation. 1990 Dec;82(6):2190-200
pubmed: 2146991
J Cell Biol. 2015 Apr 13;209(1):13-22
pubmed: 25869663
J Heart Lung Transplant. 2015 Nov;34(11):1366-75
pubmed: 26210752
Am J Respir Cell Mol Biol. 2015 Oct;53(4):500-12
pubmed: 25719275
Blood. 1993 Jul 15;82(2):337-42
pubmed: 8329693
Nat Med. 2019 Aug;25(8):1280-1289
pubmed: 31359001
Nat Commun. 2018 Nov 1;9(1):4567
pubmed: 30385745
EBioMedicine. 2016 Oct;12:280-294
pubmed: 27688095
Br J Haematol. 1990 Nov;76(3):333-9
pubmed: 2261343
JCI Insight. 2017 Nov 16;2(22):
pubmed: 29202457
Nat Med. 2000 Apr;6(4):389-95
pubmed: 10742145
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4
pubmed: 7539918
J Am Coll Cardiol. 2019 Jan 22;73(2):190-209
pubmed: 30654892
Am J Transl Res. 2018 Oct 15;10(10):3265-3275
pubmed: 30416667
Immunity. 2013 Jan 24;38(1):79-91
pubmed: 23273845
Cell. 2012 Jan 20;148(1-2):33-45
pubmed: 22265400
Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2550-2561
pubmed: 30354251
Nat Rev Cancer. 2017 Aug;17(8):457-474
pubmed: 28706266
Nature. 2019 Feb;566(7744):383-387
pubmed: 30760925
PLoS Biol. 2012;10(10):e1001407
pubmed: 23091420
Circulation. 2020 Nov 24;142(21):2060-2075
pubmed: 32962412
Int J Dev Biol. 2011;55(3):261-8
pubmed: 21710434
Cell. 2010 Oct 1;143(1):134-44
pubmed: 20887898
Nat Med. 2016 Jun;22(6):657-65
pubmed: 27183216
J Clin Invest. 1995 Jul;96(1):273-81
pubmed: 7615796
J Cell Biol. 2015 Mar 30;208(7):987-1001
pubmed: 25825518
Am J Pathol. 2011 Jul;179(1):167-79
pubmed: 21703400
Nat Med. 2018 Sep;24(9):1418-1429
pubmed: 30038218
Basic Res Cardiol. 2020 Dec 9;115(6):78
pubmed: 33296022
Nat Commun. 2018 May 25;9(1):2073
pubmed: 29802249
Nat Nanotechnol. 2020 Feb;15(2):154-161
pubmed: 31988506
Methods Mol Biol. 2018;1784:263-275
pubmed: 29761406
Nature. 2013 Jun 27;498(7455):492-6
pubmed: 23748444
Cell. 1995 Jul 28;82(2):321-30
pubmed: 7628020
Nat Commun. 2021 Jan 29;12(1):681
pubmed: 33514719
Genesis. 2017 Sep;55(9):
pubmed: 28845554
Cell. 2019 Mar 7;176(6):1325-1339.e22
pubmed: 30827679
Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L1-8
pubmed: 17384082
Eur J Vasc Endovasc Surg. 2009 Jul;38(1):104-12
pubmed: 19233690
Nat Genet. 1999 Oct;23(2):189-93
pubmed: 10508515
Sci Rep. 2020 Jan 24;10(1):1136
pubmed: 31980720
Nature. 2009 Feb 12;457(7231):887-91
pubmed: 19129762
Circ Res. 2018 Oct 26;123(10):1143-1151
pubmed: 30359189
Stroke. 2008 Mar;39(3):886-92
pubmed: 18239167
J Cell Biol. 2007 Oct 22;179(2):247-54
pubmed: 17954608
Circ Res. 2016 Feb 19;118(4):692-702
pubmed: 26892967
J Immunol Methods. 2014 Jun;408:89-100
pubmed: 24857755
Nat Genet. 1994 Dec;8(4):345-51
pubmed: 7894484
Circulation. 2012 Aug 28;126(9):1067-78
pubmed: 22855570
Arterioscler Thromb Vasc Biol. 1997 Jul;17(7):1203-9
pubmed: 9261247
Circulation. 2021 May 25;143(21):2110-2116
pubmed: 34029141
Circulation. 2010 Aug 31;122(9):920-7
pubmed: 20713898
Cell Rep. 2018 Apr 24;23(4):1152-1165
pubmed: 29694892
Pulm Circ. 2011 Jan-Mar;1(1):3-16
pubmed: 22034593
Nat Commun. 2019 Jun 24;10(1):2761
pubmed: 31235698
Eur Heart J. 2019 Aug 7;40(30):2507-2520
pubmed: 31162546
Nat Commun. 2017 Feb 09;8:14361
pubmed: 28181491
J Am Coll Cardiol. 2021 Apr 13;77(14):1747-1759
pubmed: 33832602
JCI Insight. 2020 Mar 26;5(6):
pubmed: 32154790
Eur J Surg. 1992 Jan;158(1):19-23
pubmed: 1348634
Circulation. 2000 May 9;101(18):2149-53
pubmed: 10801754
Exp Mol Pathol. 1979 Dec;31(3):367-86
pubmed: 510516
Nature. 1961 Apr 22;190:372-3
pubmed: 13764598
Cell Rep. 2020 Oct 27;33(4):108326
pubmed: 33113366
J Cell Biol. 1990 Nov;111(5 Pt 1):2149-58
pubmed: 2172262
Cell Stem Cell. 2018 Aug 02;23(2):210-225.e6
pubmed: 30075129
Nature. 2016 Aug 4;536(7614):86-90
pubmed: 27437576
Nat Med. 2008 Jan;14(1):64-8
pubmed: 18084302
Nat Commun. 2016 Jun 24;7:11853
pubmed: 27340017
Arthritis Rheum. 2007 Sep;56(9):2905-12
pubmed: 17763428
Hum Mol Genet. 1999 Nov;8(12):2325-33
pubmed: 10545614
Genes Dev. 1998 Jan 15;12(2):149-62
pubmed: 9436976
Genesis. 2000 Sep;28(1):15-22
pubmed: 11020712
Immunometabolism. 2021;3(3):
pubmed: 34178388
Nat Rev Cancer. 2002 Oct;2(10):727-39
pubmed: 12360276
J Clin Invest. 1994 Mar;93(3):1234-42
pubmed: 8132763
Am J Pathol. 1997 Sep;151(3):697-705
pubmed: 9284818
Arteriosclerosis. 1990 Nov-Dec;10(6):1082-7
pubmed: 2173900
Nature. 2021 Apr;592(7853):296-301
pubmed: 33731931
Am J Pathol. 1998 Apr;152(4):913-23
pubmed: 9546352
Nat Med. 2013 Feb;19(2):227-31
pubmed: 23353556
Cardiovasc Res. 2023 May 22;119(5):1279-1294
pubmed: 35994249
Science. 2014 Nov 14;346(6211):1258810
pubmed: 25395543
Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2836-8
pubmed: 23065827
Science. 2017 Feb 24;355(6327):842-847
pubmed: 28104796
Blood. 2013 Feb 14;121(7):1094-101
pubmed: 23243284
Circ Res. 1994 Oct;75(4):669-81
pubmed: 7923613
Circ Res. 2003 May 30;92(10):1162-9
pubmed: 12714563
J Am Heart Assoc. 2018 Jul 12;7(14):
pubmed: 30005552
Cardiovasc Res. 2018 Mar 15;114(4):551-564
pubmed: 29385432
Am J Hum Genet. 2003 Dec;73(6):1459-64
pubmed: 14624391
PLoS One. 2010 Jul 26;5(7):e11786
pubmed: 20668652
Nat Med. 2013 Sep;19(9):1166-72
pubmed: 23933982
JVS Vasc Sci. 2021 May 15;2:136-148
pubmed: 34617064
Circulation. 2006 May 9;113(18):2245-52
pubmed: 16684874
Nat Genet. 2005 Mar;37(3):275-81
pubmed: 15731757
Nat Cardiovasc Res. 2023 Jan 16;2:144-158
pubmed: 36949957
Am J Hum Genet. 2004 Feb;74(2):326-37
pubmed: 14740320
Am J Respir Cell Mol Biol. 2012 Jul;47(1):11-9
pubmed: 22323363
Science. 2012 Aug 10;337(6095):730-5
pubmed: 22855427
Acta Histochem. 2016 Apr;118(3):256-62
pubmed: 26858185
J Cell Biochem. 2005 Oct 15;96(3):447-62
pubmed: 16088940
Nature. 2021 Apr;592(7855):524-533
pubmed: 33883728
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14284-9
pubmed: 26540726
Development. 2013 Jul;140(13):2835-46
pubmed: 23757414
Am J Hum Genet. 2005 Jan;76(1):42-51
pubmed: 15543491
Cell Rep. 2014 Mar 13;6(5):809-17
pubmed: 24582963
Nat Rev Cancer. 2021 Jun;21(6):379-392
pubmed: 33727690
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
J Clin Invest. 1992 May;89(5):1438-44
pubmed: 1349026
Nat Cardiovasc Res. 2022 Mar;1(3):253-262
pubmed: 35990913
Cell. 2021 Mar 4;184(5):1348-1361.e22
pubmed: 33636128
Circ Res. 2001 Jan 19;88(1):E2-E11
pubmed: 11139485
Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):203-211
pubmed: 36519470
Cardiovasc Res. 2012 Feb 1;93(2):223-31
pubmed: 22012957
JCI Insight. 2021 Mar 22;6(6):
pubmed: 33591958
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6730-5
pubmed: 12746502
Circ Res. 2016 Dec 9;119(12):1313-1323
pubmed: 27682618
Dev Dyn. 2006 Dec;235(12):3413-22
pubmed: 17072878
Nat Rev Cardiol. 2019 Dec;16(12):727-744
pubmed: 31243391
Sci Transl Med. 2015 Oct 7;7(308):308ra159
pubmed: 26446956
Circulation. 2017 Jan 31;135(5):476-489
pubmed: 28137963
Nature. 2011 Jun 08;475(7355):222-5
pubmed: 21654748
Proc Natl Acad Sci U S A. 1976 Feb;73(2):651-3
pubmed: 1061164
Circ Res. 2021 Jan 8;128(1):133-135
pubmed: 33146591
Nat Commun. 2019 Feb 8;10(1):650
pubmed: 30737373
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15818-15826
pubmed: 32541024
N Engl J Med. 2017 Jul 13;377(2):111-121
pubmed: 28636844
Eur Heart J. 2021 Oct 14;42(39):4077-4088
pubmed: 34279021
Circ Res. 1996 Feb;78(2):188-95
pubmed: 8575061
JCI Insight. 2021 May 24;6(10):
pubmed: 33848265
Stem Cell Reports. 2020 Apr 14;14(4):551-560
pubmed: 32220332
Cell Stem Cell. 2018 May 3;22(5):779
pubmed: 29727685
EBioMedicine. 2022 Apr;78:103964
pubmed: 35339897
Cell Res. 2016 Oct;26(10):1079-1098
pubmed: 27364685
Nat Med. 2017 Oct;23(10):1176-1190
pubmed: 28920957
Nature. 2022 Dec;612(7939):301-309
pubmed: 36450978
Adv Pharmacol. 2017;78:323-350
pubmed: 28212800
Cell Stem Cell. 2020 Jan 2;26(1):81-96.e4
pubmed: 31883835
Cell Stem Cell. 2018 Mar 1;22(3):384-397.e6
pubmed: 29429943
Circulation. 2020 Jan 14;141(2):124-131
pubmed: 31707836
Physiol Rev. 2011 Jan;91(1):327-87
pubmed: 21248169
Nat Metab. 2021 Feb;3(2):166-181
pubmed: 33619382
Nat Rev Dis Primers. 2019 Aug 16;5(1):56
pubmed: 31420554
Am J Physiol Lung Cell Mol Physiol. 2003 Oct;285(4):L819-28
pubmed: 12857671
Circ Res. 2018 Mar 2;122(5):670-677
pubmed: 29358229
Am J Pathol. 2014 Jan;184(1):148-58
pubmed: 24332015
Circ Res. 2014 Sep 12;115(7):662-7
pubmed: 25070003
Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):e74-e84
pubmed: 35109671
N Engl J Med. 2021 Jan 28;384(4):382-383
pubmed: 33503349
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1753-6
pubmed: 4515934
Circulation. 2015 Mar 17;131(11):1006-18
pubmed: 25593290
Clin Chest Med. 2007 Mar;28(1):23-42, vii
pubmed: 17338926
Nat Methods. 2011 Mar;8(3):253-9
pubmed: 21297621
Front Immunol. 2018 Oct 17;9:2334
pubmed: 30386331
Nat Methods. 2011 Mar;8(3):260-6
pubmed: 21297619
Circulation. 2020 Oct 20;142(16):1545-1561
pubmed: 32794408
Genes Dev. 2004 Nov 15;18(22):2730-5
pubmed: 15545631
Nat Rev Cardiol. 2023 Mar;20(3):197-210
pubmed: 36198871
Nature. 2005 Sep 15;437(7057):426-31
pubmed: 16163360
J Cell Biol. 1993 Nov;123(3):741-7
pubmed: 8227136
Neurosurgery. 1995 Oct;37(4):591-605
pubmed: 8559286
Cardiovasc Pathol. 2013 Mar-Apr;22(2):126-32
pubmed: 22959236
Cancer Res. 2016 Mar 15;76(6):1348-53
pubmed: 26719541
Rheumatology (Oxford). 2011 Mar;50(3):518-31
pubmed: 21071477
N Engl J Med. 2014 Dec 25;371(26):2488-98
pubmed: 25426837
Ann N Y Acad Sci. 2001 Dec;953:75-84
pubmed: 11795425
J Neurol Neurosurg Psychiatry. 2001 Aug;71(2):188-92
pubmed: 11459890
JCI Insight. 2017 Oct 5;2(19):
pubmed: 28978793
Cell. 2017 Aug 10;170(4):800-814.e18
pubmed: 28802047
Nature. 2011 Aug 24;476(7361):409-13
pubmed: 21866153
Am J Respir Crit Care Med. 2009 Oct 15;180(8):780-7
pubmed: 19628780
Nat Aging. 2023 Jan;3(1):64-81
pubmed: 36743663
Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1110-H1119
pubmed: 28213405
Cell Stem Cell. 2020 Apr 2;26(4):542-557.e11
pubmed: 32243809
JCI Insight. 2019 Feb 21;4(4):
pubmed: 30830865
Blood Adv. 2020 Jun 9;4(11):2430-2438
pubmed: 32492156
Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1149-1159
pubmed: 30943775
Nature. 2020 Oct;586(7831):763-768
pubmed: 33057201
Nat Immunol. 2020 Oct;21(10):1194-1204
pubmed: 32895539
Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1248-58
pubmed: 17379839
Science. 1987 Jul 24;237(4813):423-6
pubmed: 3603030
JAMA Cardiol. 2022 May 1;7(5):521-528
pubmed: 35385050
EMBO Mol Med. 2015 Nov 26;8(1):6-24
pubmed: 26612856
Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1725-32
pubmed: 20558819
Nature. 2012 Jan 18;481(7381):306-13
pubmed: 22258609
Nat Med. 2015 Jun;21(6):628-37
pubmed: 25985364
Genesis. 2008 Feb;46(2):74-80
pubmed: 18257043