Activation of M1 muscarinic acetylcholine receptors by proline-rich oligopeptide 7a (<EDGPIPP) from
Bioactive peptide
Bothrops jararaca
Neuroprotection
Proline-rich oligopeptide
Journal
The journal of venomous animals and toxins including tropical diseases
ISSN: 1678-9199
Titre abrégé: J Venom Anim Toxins Incl Trop Dis
Pays: Brazil
ID NLM: 101201501
Informations de publication
Date de publication:
2024
2024
Historique:
received:
16
07
2023
accepted:
22
12
2023
medline:
16
2
2024
pubmed:
16
2
2024
entrez:
16
2
2024
Statut:
epublish
Résumé
The bioactive peptides derived from snake venoms of the Viperidae family species have been promising as therapeutic candidates for neuroprotection due to their ability to prevent neuronal cell loss, injury, and death. Therefore, this study aimed to evaluate the cytoprotective effects of a synthetic proline-rich oligopeptide 7a (PRO-7a; <EDGPIPP) from Both cells were pre-treated for four hours with different concentrations of PRO-7a, submitted to H PRO-7a was not cytoprotective in C6 cells, but potentiated the H For the first time, this work provides evidence that PRO-7a-induced neuroprotection seems to be mediated through M1 mAChR activation in PC12 cells, which reduces oxidative stress independently of AsS activity and L-arginine bioavailability.
Sections du résumé
Background
UNASSIGNED
The bioactive peptides derived from snake venoms of the Viperidae family species have been promising as therapeutic candidates for neuroprotection due to their ability to prevent neuronal cell loss, injury, and death. Therefore, this study aimed to evaluate the cytoprotective effects of a synthetic proline-rich oligopeptide 7a (PRO-7a; <EDGPIPP) from
Methods
UNASSIGNED
Both cells were pre-treated for four hours with different concentrations of PRO-7a, submitted to H
Results
UNASSIGNED
PRO-7a was not cytoprotective in C6 cells, but potentiated the H
Conclusions
UNASSIGNED
For the first time, this work provides evidence that PRO-7a-induced neuroprotection seems to be mediated through M1 mAChR activation in PC12 cells, which reduces oxidative stress independently of AsS activity and L-arginine bioavailability.
Identifiants
pubmed: 38362565
doi: 10.1590/1678-9199-JVATITD-2023-0043
pmc: PMC10868729
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e20230043Déclaration de conflit d'intérêts
Competing interests: Not applicable.