In vivo chronic scaffolding force of a resorbable magnesium scaffold.

The aim of this study is to qualitatively characterize the in vivo chronic scaffolding force of the Magmaris® Resorbable Magnesium Scaffold (RMS). This important parameter of scaffolds must be balanced between sufficient radial support during the healing period of the vessel and avoidance of long-term vessel caging. A finite element model was established using preclinical animal data and used to predict the device diameter and scaffolding force up to 90 days after implantation. To account for scaffold resorption, it included backbone degradation as well as formation of discontinuities as observed in vivo. The predictions of the model regarding acute recoil and chronic development of the device diameter were in good agreement with the preclinical data, supporting the validity of the model. It was found that after 28 and 90 days, the Magmaris® RMS retained 90 % and 47 % of its initial scaffolding force, respectively. The reduction in scaffolding force was mainly driven by discontinuities in the meandering segments. Finite element analysis combined with preclinical data is a reliable method to characterize the chronic scaffolding force.

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Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Michael Joner reports a relationship with Abbott Vascular that includes: speaking and lecture fees. Michael Joner reports a relationship with Alchimedics that includes: consulting or advisory. Michael Joner reports a relationship with AstraZeneca that includes: speaking and lecture fees. Michael Joner reports a relationship with Biotronik that includes: board membership, consulting or advisory, and speaking and lecture fees. Michael Joner reports a relationship with Boston Scientific that includes: funding grants, speaking and lecture fees, and travel reimbursement. Michael Joner reports a relationship with Cardiac Dimensions that includes: consulting or advisory, funding grants, speaking and lecture fees, and travel reimbursement. Michael Joner reports a relationship with Edwards Lifesciences that includes: board membership, funding grants, speaking and lecture fees, and travel reimbursement. Michael Joner reports a relationship with Infraredx that includes: funding grants. Michael Joner reports a relationship with Recor Medical that includes: speaking and lecture fees. Michael Joner reports a relationship with Shockwave that includes: consulting or advisory and speaking and lecture fees. Michael Joner reports a relationship with SIS Medical that includes: travel reimbursement. Michael Joner reports a relationship with TriCares that includes: consulting or advisory. Michael Joner reports a relationship with Veryan that includes: consulting or advisory. Martin Pritsch, Philine Baumann-Zumstein and Daniel Lootz are employees of BIOTRONIK AG. Christoph Forkmann is an employee of CORTRONIK GmbH, a subsidiary of BIOTRONIK.