Comparative analysis of asymptomatic infection prevalence in beta, delta, and omicron surges of COVID-19.

Asymptomatic individuals Beta surge Delta surge Omicron surge SARS-CoV-2

Journal

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
ISSN: 1678-4391
Titre abrégé: Braz J Infect Dis
Pays: Brazil
ID NLM: 9812937

Informations de publication

Date de publication:
13 Feb 2024
Historique:
received: 30 09 2023
revised: 23 12 2023
accepted: 24 01 2024
medline: 17 2 2024
pubmed: 17 2 2024
entrez: 16 2 2024
Statut: aheadofprint

Résumé

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a devastating impact on the global population, with an estimated 650 million people infected and more than 6.6 million lives lost. Asymptomatic individuals have been shown to play a significant role in the transmission of the virus. Therefore, this study aims to investigate and compare the prevalence of asymptomatic individuals across three waves associated with the Beta, Delta, and omicron variants of the virus. This retrospective study was conducted between December 2020 and March 2022. The study population consisted of passengers on international flights who were referred to the Gerash Clinical and Molecular Diagnosis Laboratory. Real-time PCR was employed for the diagnosis of SARS-CoV-2. Out of a total of 8592 foreign travelers referred to our laboratory, 139 (1.16 %) tested positive for SARS-CoV-2 infection and were asymptomatic. During the Beta surge, 35 (1.49 %) out of 2335 passengers tested positive for SARS-CoV-2. In the Delta surge, 31 (0.6 %) out of 5127 passengers tested positive. However, during the Omicron surge, a significantly higher number of passengers, specifically 73 (6.46 %) out of 1130, had a positive result for the SARS-CoV-2 test. Considering the significant role of asymptomatic transmission in the spread of COVID-19, it is imperative to reconsider health policies when dealing with future surges of the Omicron subvariants. Additionally, we strongly recommend that the World Health Organization prioritize the development and distribution of second-generation vaccines that target not only disease but also infection prevention.

Sections du résumé

BACKGROUND BACKGROUND
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a devastating impact on the global population, with an estimated 650 million people infected and more than 6.6 million lives lost. Asymptomatic individuals have been shown to play a significant role in the transmission of the virus. Therefore, this study aims to investigate and compare the prevalence of asymptomatic individuals across three waves associated with the Beta, Delta, and omicron variants of the virus.
METHODS METHODS
This retrospective study was conducted between December 2020 and March 2022. The study population consisted of passengers on international flights who were referred to the Gerash Clinical and Molecular Diagnosis Laboratory. Real-time PCR was employed for the diagnosis of SARS-CoV-2.
RESULTS RESULTS
Out of a total of 8592 foreign travelers referred to our laboratory, 139 (1.16 %) tested positive for SARS-CoV-2 infection and were asymptomatic. During the Beta surge, 35 (1.49 %) out of 2335 passengers tested positive for SARS-CoV-2. In the Delta surge, 31 (0.6 %) out of 5127 passengers tested positive. However, during the Omicron surge, a significantly higher number of passengers, specifically 73 (6.46 %) out of 1130, had a positive result for the SARS-CoV-2 test.
CONCLUSION CONCLUSIONS
Considering the significant role of asymptomatic transmission in the spread of COVID-19, it is imperative to reconsider health policies when dealing with future surges of the Omicron subvariants. Additionally, we strongly recommend that the World Health Organization prioritize the development and distribution of second-generation vaccines that target not only disease but also infection prevention.

Identifiants

pubmed: 38365183
pii: S1413-8670(24)00007-2
doi: 10.1016/j.bjid.2024.103724
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103724

Informations de copyright

Copyright © 2024. Published by Elsevier España, S.L.U.

Déclaration de conflit d'intérêts

Conflicts of interest The authors declare no conflicts of interest.

Auteurs

Mohammad Jafari (M)

Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran.

Ahmad Jabrodini (A)

Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran.

Aliyar Pirouzi (A)

Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran.

Ahmad Meshkin (A)

Education Development Center, Committee of Medical Education Development, Gerash University of Medical Sciences, Gerash, Iran.

Mehdi Mohsenzadeh (M)

Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran; Reproductive Biology, Gerash University of Medical Sciences, Gerash, Iran. Electronic address: Mohsenzadeh@gerums.ac.ir.

Classifications MeSH