Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort.
Alzheimer’s disease (AD)
GR@CE
Genome-wide association study (GWAS)
Mendelian randomization (MR)
NORFACE
Optical coherence tomography (OCT)
Polygenic risk score (PRS)
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
16 Feb 2024
16 Feb 2024
Historique:
received:
01
07
2023
accepted:
26
01
2024
medline:
17
2
2024
pubmed:
17
2
2024
entrez:
16
2
2024
Statut:
epublish
Résumé
Several studies have reported a relationship between retinal thickness and dementia. Therefore, optical coherence tomography (OCT) has been proposed as an early diagnosis method for Alzheimer's disease (AD). In this study, we performed a genome-wide association study (GWAS) aimed at identifying genes associated with retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) thickness assessed by OCT and exploring the relationships between the spectrum of cognitive decline (including AD and non-AD cases) and retinal thickness. RNFL and GCIPL thickness at the macula were determined using two different OCT devices (Triton and Maestro). These determinations were tested for association with common single nucleotide polymorphism (SNPs) using adjusted linear regression models and combined using meta-analysis methods. Polygenic risk scores (PRSs) for retinal thickness and AD were generated. Several genetic loci affecting retinal thickness were identified across the genome in accordance with previous reports. The genetic overlap between retinal thickness and dementia, however, was weak and limited to the GCIPL layer; only those observable with all-type dementia cases were considered. Our study does not support the existence of a genetic link between dementia and retinal thickness.
Sections du résumé
BACKGROUND
BACKGROUND
Several studies have reported a relationship between retinal thickness and dementia. Therefore, optical coherence tomography (OCT) has been proposed as an early diagnosis method for Alzheimer's disease (AD). In this study, we performed a genome-wide association study (GWAS) aimed at identifying genes associated with retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) thickness assessed by OCT and exploring the relationships between the spectrum of cognitive decline (including AD and non-AD cases) and retinal thickness.
METHODS
METHODS
RNFL and GCIPL thickness at the macula were determined using two different OCT devices (Triton and Maestro). These determinations were tested for association with common single nucleotide polymorphism (SNPs) using adjusted linear regression models and combined using meta-analysis methods. Polygenic risk scores (PRSs) for retinal thickness and AD were generated.
RESULTS
RESULTS
Several genetic loci affecting retinal thickness were identified across the genome in accordance with previous reports. The genetic overlap between retinal thickness and dementia, however, was weak and limited to the GCIPL layer; only those observable with all-type dementia cases were considered.
CONCLUSIONS
CONCLUSIONS
Our study does not support the existence of a genetic link between dementia and retinal thickness.
Identifiants
pubmed: 38365752
doi: 10.1186/s13195-024-01398-8
pii: 10.1186/s13195-024-01398-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
38Subventions
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : ACE alzheimer Center Barcelona
ID : Intramural Funding
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : PI19/00335, PI17/01474, AC17/00100, PI19/01301, PI22/01403, PMP22/00022
Informations de copyright
© 2024. The Author(s).
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