Discovery of an antitumor compound from xenorhabdus stockiae HN_xs01.
Antitumor
Apoptosis
Secondary metabolite
Xenorhabdus
Journal
World journal of microbiology & biotechnology
ISSN: 1573-0972
Titre abrégé: World J Microbiol Biotechnol
Pays: Germany
ID NLM: 9012472
Informations de publication
Date de publication:
17 Feb 2024
17 Feb 2024
Historique:
received:
25
04
2023
accepted:
01
02
2024
medline:
17
2
2024
pubmed:
17
2
2024
entrez:
17
2
2024
Statut:
epublish
Résumé
Xenorhabdus, known for its symbiotic relationship with Entomopathogenic nematodes (EPNs), belongs to the Enterobacteriaceae family. This dual-host symbiotic nematode exhibits pathogenic traits, rendering it a promising biocontrol agent against insects. Our prior investigations revealed that Xenorhabdus stockiae HN_xs01, isolated in our laboratory, demonstrates exceptional potential in halting bacterial growth and displaying anti-tumor activity. Subsequently, we separated and purified the supernatant of the HN_xs01 strain and obtained a new compound with significant inhibitory activity on tumor cells, which we named XNAE. Through LC-MS analysis, the mass-to-nucleus ratio of XNAE was determined to be 254.24. Our findings indicated that XNAE exerts a time- and dose-dependent inhibition on B16 and HeLa cells. After 24 h, its IC
Identifiants
pubmed: 38366186
doi: 10.1007/s11274-024-03915-1
pii: 10.1007/s11274-024-03915-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101Subventions
Organisme : National Natural Science Foundation of China
ID : 32070090
Organisme : Research Foundation of Education Bureau of Hunan Province
ID : 19K053
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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