Lower region-specific gray matter volume in females with atypical anorexia nervosa and anorexia nervosa.
anorexia nervosa
atypical anorexia nervosa
body mass index
cortex
diagnostic criteria
feeding and eating disorders
restrictive eating disorders
structural magnetic resonance imaging
Journal
The International journal of eating disorders
ISSN: 1098-108X
Titre abrégé: Int J Eat Disord
Pays: United States
ID NLM: 8111226
Informations de publication
Date de publication:
17 Feb 2024
17 Feb 2024
Historique:
revised:
29
01
2024
received:
29
09
2023
accepted:
30
01
2024
medline:
17
2
2024
pubmed:
17
2
2024
entrez:
17
2
2024
Statut:
aheadofprint
Résumé
Few studies have focused on brain structure in atypical anorexia nervosa (atypical AN). This study investigates differences in gray matter volume (GMV) between females with anorexia nervosa (AN) and atypical AN, and healthy controls (HC). Structural magnetic resonance imaging data were acquired for 37 AN, 23 atypical AN, and 41 HC female participants. Freesurfer was used to extract GMV, cortical thickness, and surface area for six brain lobes and associated cortical regions of interest (ROI). Primary analyses employed linear mixed-effects models to compare group differences in lobar GMV, followed by secondary analyses on ROIs within significant lobes. We also explored relationships between cortical gray matter and both body mass index (BMI) and symptom severity. Our primary analyses revealed significant lower GMV in frontal, temporal and parietal areas (FDR < .05) in AN and atypical AN when compared to HC. Lobar GMV comparisons were non-significant between atypical AN and AN. The parietal lobe exhibited the greatest proportion of affected cortical ROIs in both AN versus HC and atypical AN versus HC. BMI, but not symptom severity, was found to be associated with cortical GMV in the parietal, frontal, temporal, and cingulate lobes. No significant differences were observed in cortical thickness or surface area. We observed lower GMV in frontal, temporal, and parietal areas, when compared to HC, but no differences between AN and atypical AN. This indicates potentially overlapping structural phenotypes between these disorders and evidence of brain changes among those who are not below the clinical underweight threshold. Despite individuals with atypical anorexia nervosa presenting above the clinical weight threshold, lower cortical gray matter volume was observed in partial, temporal, and frontal cortices, compared to healthy individuals. No significant differences were found in cortical gray matter volume between anorexia nervosa and atypical anorexia nervosa. This underscores the importance of continuing to assess and target weight gain in clinical care, even for those who are presenting above the low-weight clinical criteria.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P30DK040561
Pays : United States
Organisme : NIH HHS
ID : 1UL1TR001102
Pays : United States
Organisme : NIMH NIH HHS
ID : 1R01MH130781
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH115247-01A1
Pays : United States
Organisme : NIMH NIH HHS
ID : K23MH125143
Pays : United States
Organisme : NIMH NIH HHS
ID : K23MH127465
Pays : United States
Organisme : NIMH NIH HHS
ID : K24MH120568
Pays : United States
Organisme : NIMH NIH HHS
ID : KL2TR002542
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH103402
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH108595
Pays : United States
Organisme : NIMH NIH HHS
ID : R03MH126143
Pays : United States
Informations de copyright
© 2024 Wiley Periodicals LLC.
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