Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia.

Infant, Newborn Humans Severe Combined Immunodeficiency / diagnosis Lymphopenia / diagnosis Neonatal Screening / methods T-Lymphocytes Cell Proliferation
Mitogen PHA PIDTC SCID Severe combined immunodeficiency T-cell lymphopenia T-cell proliferation

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
Apr 2024
Historique:
received: 28 12 2023
revised: 05 02 2024
accepted: 10 02 2024
medline: 18 3 2024
pubmed: 18 2 2024
entrez: 17 2 2024
Statut: ppublish

Résumé

Severe combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, there was a higher proliferative response with the PHA flow assay compared to the

Identifiants

DOI: 10.1016/j.clim.2024.109942 PMID: 38367737
pubmed: 38367737
pii: S1521-6616(24)00053-6
doi: 10.1016/j.clim.2024.109942
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109942

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest RSA has been on the advisory board for Horizon Pharma (now Amgen) and Sobi in the past 2 years but is not currently serving in that capacity. RM is an employee of Pharming Healthcare Inc., Warren, NJ. JWL is an employee and shareholder of Bluebird Bio, and has been a speaker/consultant and on the advisory board for Sobi, Inc.

Auteurs

Roshini S Abraham (RS)

Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, OH, USA. Electronic address: Roshini.Abraham@nationwidechildrens.org.

Amrita Basu (A)

Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, OH, USA.

Jennifer R Heimall (JR)

Division of Allergy and Immunology, Children's Hospital of Philadelphia, PA, USA.

Elizabeth Dunn (E)

Division of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

Alison Yip (A)

Division of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

Malika Kapadia (M)

Division of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pediatrics, Harvard University Medical School, Boston, MA, USA.

Neena Kapoor (N)

Transplantation and Cellular Therapy Program, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Lisa Forbes Satter (LF)

Pediatrics, Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.

Rebecca Buckley (R)

Departments of Pediatrics and Immunology, Duke University Medical Center, Durham, NC, USA.

Richard O'Reilly (R)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Geoffrey D E Cuvelier (GDE)

Manitoba Blood and Marrow Transplant Program, CancerCare Manitoba, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.

Sharat Chandra (S)

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Jeffrey Bednarski (J)

Division of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

Sonali Chaudhury (S)

Division of Hematology, Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago-Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Theodore B Moore (TB)

Division of Hematology/Oncology, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA.

Hilary Haines (H)

Division of Pediatric Hematology-Oncology and Bone Marrow Transplant, University of Alabama at Birmingham, Birmingham, AL, USA.

Blachy J Dávila Saldaña (BJ)

Division of Blood and Marrow Transplantation, Children's National Hospital-George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Deepakbabu Chellapandian (D)

Blood and Marrow Transplant, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.

Ahmad Rayes (A)

Division of Pediatric Hematology and Oncology, Intermountain Primary Childrens Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA.

Karin Chen (K)

Department of Pediatrics, University of Washington-Seattle Children's Hospital, Seattle, WA, USA.

Emi Caywood (E)

Nemours Children's Health Delaware, Thomas Jefferson University, Wilmington, DE, USA.

Shanmuganathan Chandrakasan (S)

Bone Marrow Transplantation Program, Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Mark Thomas Vander Lugt (MTV)

Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI, USA.

Christen Ebens (C)

Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy, University of Minnesota, Minneapolis, MN, USA.

Pierre Teira (P)

Pediatric Immunology and Rheumatology Division, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.

Evan Shereck (E)

Division of Pediatric Hematology/Oncology, Oregon Health and Science University, Portland, OR, USA.

Holly Miller (H)

Phoenix Children's Hospital, Phoenix, AZ, USA.

Victor Aquino (V)

Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Hesham Eissa (H)

Division of Pediatric Hematology-Oncology-BMT, University of Colorado, Aurora, CO, USA.

Lolie C Yu (LC)

Division of Pediatric Hematology-Oncology/HSCT, LSUHSC and Children's Hospital, New Orleans, LA, USA.

Alfred Gillio (A)

Institute for Pediatric Cancer and Blood Disorders, Hackensack University Medical Center, Hackensack, NJ, USA.

Lisa Madden (L)

Pediatric Blood and Marrow Transplantation Program, Texas Transplant Institute, Methodist Children's Hospital, San Antonio, TX, USA.

Alan Knutsen (A)

Department of Pediatrics, Pediatric Allergy and Immunology Division, Saint Louis University, St Louis, MO, USA.

Ami J Shah (AJ)

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine Pediatric Stem Cell Transplantation, Stanford University, Stanford, CA, USA.

Kenneth DeSantes (K)

American Family Children's Hospital, University of Wisconsin, Madison, WI, USA.

Jessie Barnum (J)

UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Larisa Broglie (L)

Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI, USA.

Avni Y Joshi (AY)

Division of Pediatric and Adult Allergy and Immunology, Mayo Clinic, Rochester, MN, USA.

Gary Kleiner (G)

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Holtz Children's Hospital at Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, FL, USA.

Jasmeen Dara (J)

Division of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

Susan Prockop (S)

Division of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pediatrics, Harvard University Medical School, Boston, MA, USA.

Caridad Martinez (C)

Pediatrics, Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.

Talal Mousallem (T)

Departments of Pediatrics and Immunology, Duke University Medical Center, Durham, NC, USA.

Joseph Oved (J)

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lauri Burroughs (L)

Department of Pediatrics, University of Washington-Seattle Children's Hospital, Seattle, WA, USA.

Rebecca Marsh (R)

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Pharming Healthcare Inc, Warren, NJ, USA.

Troy R Torgerson (TR)

Department of Pediatrics, University of Washington-Seattle Children's Hospital, Seattle, WA, USA.

Jennifer W Leiding (JW)

Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University Baltimore, MD and Institute for Clinical and Translational Research, Johns Hopkins All Childrens Hospital, St. Petersburg, FL, USA.

Sung Yun Pai (SY)

Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Donald B Kohn (DB)

Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.

Michael A Pulsipher (MA)

Division of Pediatric Hematology and Oncology, Intermountain Primary Childrens Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA.

Linda M Griffith (LM)

Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Luigi D Notarangelo (LD)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Morton J Cowan (MJ)

Division of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

Jennifer Puck (J)

Division of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

Christopher C Dvorak (CC)

Division of Allergy, Immunology, and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

Elie Haddad (E)

Pediatric Immunology and Rheumatology Division, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Relevance of lymphocyte proliferation to PHA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Relevance of lymphocyte proliferation to PHA...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Maladies d'immunodéficience primaire › Immunodéficience combinée grave › Relevance of lymphocyte proliferation to PHA...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Lymphopénie › Relevance of lymphocyte proliferation to PHA...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Dépistage de masse › Dépistage néonatal › Relevance of lymphocyte proliferation to PHA...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Relevance of lymphocyte proliferation to PHA...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Relevance of lymphocyte proliferation to PHA...