Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases.
Brain disease
Cerebrospinal fluid
Disease diagnosis and therapeutics
Immune microenvironment
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
17 02 2024
17 02 2024
Historique:
received:
25
09
2023
accepted:
01
02
2024
medline:
19
2
2024
pubmed:
18
2
2024
entrez:
17
2
2024
Statut:
epublish
Résumé
Abnormal inflammatory states in the brain are associated with a variety of brain diseases. The dynamic changes in the number and function of immune cells in cerebrospinal fluid (CSF) are advantageous for the early prediction and diagnosis of immune diseases affecting the brain. The aggregated factors and cells in inflamed CSF may represent candidate targets for therapy. The physiological barriers in the brain, such as the blood‒brain barrier (BBB), establish a stable environment for the distribution of resident immune cells. However, the underlying mechanism by which peripheral immune cells migrate into the brain and their role in maintaining immune homeostasis in CSF are still unclear. To advance our understanding of the causal link between brain diseases and immune cell status, we investigated the characteristics of immune cell changes in CSF and the molecular mechanisms involved in common brain diseases. Furthermore, we summarized the diagnostic and treatment methods for brain diseases in which immune cells and related cytokines in CSF are used as targets. Further investigations of the new immune cell subtypes and their contributions to the development of brain diseases are needed to improve diagnostic specificity and therapy.
Identifiants
pubmed: 38368403
doi: 10.1186/s12964-024-01509-w
pii: 10.1186/s12964-024-01509-w
pmc: PMC10874090
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
132Subventions
Organisme : Youth Innovation Promotion Association of the Chinese Academy of Sciences
ID : 2022042
Organisme : National Natural Science Foundation of China
ID : 22076210
Organisme : National Natural Science Foundation of China
ID : 22150006 and 22021003
Organisme : National Key Research and Development Program of China
ID : 2018YFA0901101
Organisme : National Key Research and Development Program of China
ID : 2021YFE0101500
Informations de copyright
© 2024. The Author(s).
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