Voltage tunes mGlu
G-protein coupled receptors (GPCR)
biosensors
metabotropic glutamate receptor (mGlu5)
neuronal plasticity
signalling
synaptic transmission
voltage sensitivity
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
18 Feb 2024
18 Feb 2024
Historique:
revised:
08
12
2023
received:
07
09
2023
accepted:
29
12
2023
medline:
19
2
2024
pubmed:
19
2
2024
entrez:
18
2
2024
Statut:
aheadofprint
Résumé
Voltage sensitivity is a common feature of many membrane proteins, including some G-protein coupled receptors (GPCRs). However, the functional consequences of voltage sensitivity in GPCRs are not well understood. In this study, we investigated the voltage sensitivity of the post-synaptic metabotropic glutamate receptor mGlu We found that mGlu Our findings suggest that mGlu
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Voltage sensitivity is a common feature of many membrane proteins, including some G-protein coupled receptors (GPCRs). However, the functional consequences of voltage sensitivity in GPCRs are not well understood.
EXPERIMENTAL APPROACH
METHODS
In this study, we investigated the voltage sensitivity of the post-synaptic metabotropic glutamate receptor mGlu
KEY RESULTS
RESULTS
We found that mGlu
CONCLUSIONS AND IMPLICATIONS
CONCLUSIONS
Our findings suggest that mGlu
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 646788 VERTICAL CITY - ERC consolidator
Pays : International
Informations de copyright
© 2024 British Pharmacological Society.
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