Rhinovirus-induced wheeze was associated with asthma development in predisposed children.
allergic sensitisation
asthma
heredity
preschool wheeze
rhinoviruses
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
19 Feb 2024
19 Feb 2024
Historique:
revised:
04
02
2024
received:
31
08
2023
accepted:
06
02
2024
medline:
19
2
2024
pubmed:
19
2
2024
entrez:
19
2
2024
Statut:
aheadofprint
Résumé
This study explored whether early-life factors, such as rhinovirus-induced wheeze and allergic sensitisation, were related to asthma at 11 years of age. We focused on 107 children aged 6-48 months, who attended the paediatric emergency department at Astrid Lindgren's Children's Hospital in Stockholm, Sweden, with acute wheeze in 2008-2012. They also attended follow-up visits at 11 years of age and were compared with 46 age-matched healthy controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with logistic regression. We found that 62.6% of the acute wheeze cases had asthma at 11 years of age. Rhinoviruses at inclusion were the only common airway viruses associated with an increased asthma risk (OR 2.4, 95% CI 1.02-5.6). Other increased risks were parental heredity for asthma and/or allergies (adjusted OR 3.4, 95% CI 1.1-9.9) and allergic sensitisation at 2 years of age (adjusted OR 3.0, 95% CI 1.02-8.7). The highest prevalence of asthma was when children had both rhinovirus-induced wheeze at inclusion and allergic sensitisation at 7 years of age. Our findings highlight the importance of hereditary factors and allergic sensitisation on the development of asthma and suggest that rhinoviruses are associated with asthma development in predisposed children.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swedish Association for Allergology
Organisme : Region Stockholm (ALF Project and Research Residency Programme)
ID : FoUI-970955
Organisme : Region Stockholm (ALF Project and Research Residency Programme)
ID : FoUI-986234
Organisme : The Pediatric Research Foundation of Astrid Lindgren Children's Hospital
Organisme : The Swedish Heart-Lung Foundation
ID : 20210424
Organisme : The Swedish Research Council
Organisme : KI-Region Stockholm Research Council
Organisme : King Karl Gustaf V 80th Birthday Foundation
Organisme : The Hesselman Foundation
Organisme : The Swedish Asthma and Allergy Association's Research Foundation
ID : F2022-0011
Organisme : The Cancer and Allergy Foundation
ID : 10668
Organisme : The Cancer and Allergy Foundation
ID : 10935
Organisme : The Swedish Society of Medicine
Organisme : The Konsul Th.C Bergh's Foundation
Organisme : The Magnus Bergvall Foundation
Organisme : The Freemason Child House Foundation
Informations de copyright
© 2024 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
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