Whole Genome Sequence Dataset of Mycobacterium tuberculosis Strains from Patients of Campania Region.
Journal
Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192
Informations de publication
Date de publication:
19 Feb 2024
19 Feb 2024
Historique:
received:
06
12
2023
accepted:
31
01
2024
medline:
21
2
2024
pubmed:
20
2
2024
entrez:
19
2
2024
Statut:
epublish
Résumé
Tuberculosis (TB) is one of the deadliest infectious disorders in the world. To effectively TB manage, an essential step is to gain insight into the lineage of Mycobacterium tuberculosis (MTB) and the distribution of drug resistance. Although the Campania region is declared a cluster area for the infection, to contribute to the effort to understand TB evolution and transmission, still poorly known, we have generated a dataset of 159 genomes of MTB strains, from Campania region collected during 2018-2021, obtained from the analysis of whole genome sequence. The results show that the most frequent MTB lineage is the 4 according for 129 strains (81.11%). Regarding drug resistance, 139 strains (87.4%) were classified as multi susceptible, while the remaining 20 (12.58%) showed drug resistance. Among the drug-resistance strains, 8 were isoniazid-resistant MTB, 4 multidrug-resistant MTB, while only one was classified as pre-extensively drug-resistant MTB. This dataset expands the existing available knowledge on drug resistance and evolution of MTB, contributing to further TB-related genomics studies to improve the management of this disease.
Identifiants
pubmed: 38374088
doi: 10.1038/s41597-024-03032-6
pii: 10.1038/s41597-024-03032-6
pmc: PMC10876956
doi:
Substances chimiques
Antitubercular Agents
0
Isoniazid
V83O1VOZ8L
Types de publication
Dataset
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
220Informations de copyright
© 2024. The Author(s).
Références
Front Microbiol. 2020 Sep 22;11:550760
pubmed: 33072011
Front Cell Infect Microbiol. 2022 Sep 23;12:943545
pubmed: 36211964
PLoS Pathog. 2022 May 26;18(5):e1010490
pubmed: 35617217
Eur J Immunol. 2014 May;44(5):1387-98
pubmed: 24481948
Microbiol Spectr. 2022 Jun 29;10(3):e0159421
pubmed: 35442078
Trop Med Infect Dis. 2019 Jun 17;4(2):
pubmed: 31212985
PLoS One. 2019 Jun 5;14(6):e0213046
pubmed: 31166945
Nucleic Acids Res. 2021 Jul 2;49(W1):W293-W296
pubmed: 33885785
PLoS One. 2018 Dec 12;13(12):e0208603
pubmed: 30540823
Nat Genet. 2016 Dec;48(12):1535-1543
pubmed: 27798628
ACS Omega. 2020 Aug 28;5(36):22684-22690
pubmed: 32954115
Sci Rep. 2020 Jan 15;10(1):327
pubmed: 31941887
PLoS Negl Trop Dis. 2010 Sep 28;4(9):e744
pubmed: 20927191
PLoS One. 2019 Mar 25;14(3):e0214088
pubmed: 30908506
Front Public Health. 2022 Sep 07;10:994745
pubmed: 36159313
J Family Community Med. 2019 May-Aug;26(2):83-91
pubmed: 31143078
Adv Exp Med Biol. 2017;1019:117-133
pubmed: 29116632
Mol Ecol. 2019 Jul;28(13):3241-3256
pubmed: 31066139
Breathe (Sheff). 2022 Mar;18(1):210149
pubmed: 35284018
Genome Med. 2019 Jun 24;11(1):41
pubmed: 31234910
Microb Genom. 2021 Feb;7(2):
pubmed: 33555243
Front Med (Lausanne). 2023 Jan 20;9:909198
pubmed: 36743681