Bicarbonate secretion and acid/base sensing by the intestine.
CFTR
Colon
Congenital chloride diarrhea
Cystic fibrosis
Inflammatory bowel disease
Intestine
SLC26a3
SLC26a6
Sodium bicarbonate cotransporter
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
19 Feb 2024
19 Feb 2024
Historique:
received:
16
11
2023
accepted:
17
01
2024
revised:
15
01
2024
medline:
20
2
2024
pubmed:
20
2
2024
entrez:
19
2
2024
Statut:
aheadofprint
Résumé
The transport of bicarbonate across the enterocyte cell membrane regulates the intracellular as well as the luminal pH and is an essential part of directional fluid movement in the gut. Since the first description of "active" transport of HCO
Identifiants
pubmed: 38374228
doi: 10.1007/s00424-024-02914-3
pii: 10.1007/s00424-024-02914-3
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Acin-Perez R, Salazar E, Kamenetsky M, Buck J, Levin LR, Manfredi G (2009) Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab 9:265–276. https://doi.org/10.1016/j.cmet.2009.01.012
doi: 10.1016/j.cmet.2009.01.012
pubmed: 19254571
pmcid: 2684673
Akiba Y, Kaunitz JD (2009) Luminal chemosensing and upper gastrointestinal mucosal defenses. Am J Clin Nutr 90:826S-831S. https://doi.org/10.3945/ajcn.2009.27462U
doi: 10.3945/ajcn.2009.27462U
pubmed: 19571224
pmcid: 3136009
Akiba Y, Ghayouri S, Takeuchi T, Mizumori M, Guth PH, Engel E, Swenson ER, Kaunitz JD (2006) Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Gastroenterology 131:142–152. https://doi.org/10.1053/j.gastro.2006.04.018
doi: 10.1053/j.gastro.2006.04.018
pubmed: 16831598
Alper SL, Stewart AK, Chernova MN, Zolotarev AS, Clark JS, Vandorpe DH (2006) Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides. Novartis Found Symp 273:107–19
doi: 10.1002/0470029579.ch8
pubmed: 17120764
Alper SL, Stewart AK, Vandorpe DH, Clark JS, Horack RZ, Simpson JE, Walker NM, Clarke LL (2011) Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange. Am J Physiol Cell Physiol 300:C276–C286. https://doi.org/10.1152/ajpcell.00366.2010
doi: 10.1152/ajpcell.00366.2010
pubmed: 21068358
Anbazhagan AN, Priyamvada S, Alrefai WA, Dudeja PK (2018) Pathophysiology of IBD associated diarrhea. Tissue Barriers 6:e1463897. https://doi.org/10.1080/21688370.2018.1463897
doi: 10.1080/21688370.2018.1463897
pubmed: 29737913
pmcid: 6179131
Argenzio RA, Southworth M, Lowe JE, Stevens CE (1977) Interrelationship of Na, HCO
doi: 10.1152/ajpendo.1977.233.6.E469
pubmed: 596440
Asano K, Matsushita T, Umeno J, Hosono N, Takahashi A, Kawaguchi T, Matsumoto T, Matsui T, Kakuta Y, Kinouchi Y, Shimosegawa T, Hosokawa M, Arimura Y, Shinomura Y, Kiyohara Y, Tsunoda T, Kamatani N, Iida M, Nakamura Y, Kubo M (2009) A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nat Genet 41:1325–1329. https://doi.org/10.1038/ng.482
doi: 10.1038/ng.482
pubmed: 19915573
Asano K, Esaki M, Umeno J, Hirano A, Maehata Y, Moriyama T, Nakamura S, Matsumoto T, Kitazono T (2015) Contribution of susceptibility variants at FCGR2A and 13q12 to the risk of relapse among Japanese patients with ulcerative colitis. J Gastroenterol 50:1094–1102. https://doi.org/10.1007/s00535-015-1062-3
doi: 10.1007/s00535-015-1062-3
pubmed: 25787843
Bieberdorf FA, Gorden P, Fordtran JS (1972) Pathogenesis of congenital alkalosis with diarrhea. Implications for the physiology of normal ileal electrolyte absorption and secretion. J Clin Invest 51:1958–1968. https://doi.org/10.1172/JCI107002
doi: 10.1172/JCI107002
pubmed: 5054457
pmcid: 292352
Binder HJ (2010) Role of colonic short-chain fatty acid transport in diarrhea. Annu Rev Physiol 72:297–313
doi: 10.1146/annurev-physiol-021909-135817
pubmed: 20148677
Binder HJ, Rajendran V, Sadasivan V, Geibel JP (2005) Bicarbonate secretion: a neglected aspect of colonic ion transport. J Clin Gastroenterol 39:S53–S58. https://doi.org/10.1097/01.mcg.0000155521.81382.3a
doi: 10.1097/01.mcg.0000155521.81382.3a
pubmed: 15758660
Boedtkjer E, Praetorius J, Füchtbauer E-M, Aalkjaer C (2008) Antibody-independent localization of the electroneutral Na
doi: 10.1152/ajpcell.00281.2007
pubmed: 18077606
Boldyreff W (1914) The self-regulation of the acidity of the gastric contents and the real acidity of the gastric juice. Q J Exp Physiol 8:1–12. https://doi.org/10.1113/expphysiol.1914.sp000167
doi: 10.1113/expphysiol.1914.sp000167
Braun T, Dods RF (1975) Development of a Mn
doi: 10.1073/pnas.72.3.1097
pubmed: 1055368
pmcid: 432473
Calam J (1995) Pathogenic mechanisms. Baillieres Clin Gastroenterol 9:487–506. https://doi.org/10.1016/0950-3528(95)90044-6
doi: 10.1016/0950-3528(95)90044-6
pubmed: 8563049
Camarillo GF, Goyon EI, Zuñiga RB, Salas LAS, Escárcega AEP, Yamamoto-Furusho JK (2020) Gene expression profiling of mediators associated with the inflammatory pathways in the intestinal tissue from patients with ulcerative colitis. Mediators Inflamm 2020:9238970. https://doi.org/10.1155/2020/9238970
doi: 10.1155/2020/9238970
pubmed: 32410873
pmcid: 7201440
Canani RB, Terrin G, Cirillo P, Castaldo G, Salvatore F, Cardillo G, Coruzzo A, Troncone R (2004) Butyrate as an effective treatment of congenital chloride diarrhea. Gastroenterology 127:630–634. https://doi.org/10.1053/j.gastro.2004.03.071
doi: 10.1053/j.gastro.2004.03.071
pubmed: 15300594
Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP (2021) Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A 118. https://doi.org/10.1073/pnas.2023871118
Carvalho ESM, Gregório SF, Power DM, Canário AVM, Fuentes J (2012) Water absorption and bicarbonate secretion in the intestine of the sea bream are regulated by transmembrane and soluble adenylyl cyclase stimulation. J Comp Physiol B Biochem Syst Environ Physiol 182:1069–1080. https://doi.org/10.1007/s00360-012-0685-4
doi: 10.1007/s00360-012-0685-4
Chang JC, Go S, Gilglioni EH, Duijst S, Panneman DM, Rodenburg RJ, Li HL, Huang HL, Levin LR, Buck J, Verhoeven AJ, Oude Elferink RPJ (2021) Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation. Biochim Biophys Acta - Bioenerg 1862:148367. https://doi.org/10.1016/j.bbabio.2020.148367
doi: 10.1016/j.bbabio.2020.148367
pubmed: 33412125
Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, Buck J (2000) Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science 289:625–628. https://doi.org/10.1126/science.289.5479.625
doi: 10.1126/science.289.5479.625
pubmed: 10915626
Chen A, Dong L, Leffler NR, Asch AS, Witte ON, Yang L V. (2011) Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. PLoS One 6. https://doi.org/10.1371/journal.pone.0027586
Chen M, Praetorius J, Zheng W, Xiao F, Riederer B, Singh AK, Stieger N, Wang J, Shull GE, Aalkjaer C, Seidler U (2012) The electroneutral Na
doi: 10.1113/jphysiol.2011.226506
pubmed: 22586225
pmcid: 3459045
Chen X, Sun X, Wang Z, Zhou X, Xu L, Li F, Zhang X, Pan J, Qi L, Qian H, Mao Z (2018) Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion. Acta Biochim Biophys Sin (Shanghai) 50:440–446. https://doi.org/10.1093/abbs/gmy026
doi: 10.1093/abbs/gmy026
pubmed: 29584803
Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, Vandorpe DH, Alper SL (2005) Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem 280:8564–8580. https://doi.org/10.1074/jbc.M411703200
doi: 10.1074/jbc.M411703200
pubmed: 15548529
Choi I, Aalkjaer C, Boulpaep EL, Boron WF (2000) An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel. Nature 405:571–575. https://doi.org/10.1038/35014615
doi: 10.1038/35014615
pubmed: 10850716
Cil O, Haggie PM, Tan J-AT, Rivera AA, Verkman AS (2021) SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. JCI insight 6. https://doi.org/10.1172/jci.insight.147699
Clapham DE, Julius D, Montell C, Schultz G (2005) International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev 57:427–450. https://doi.org/10.1124/pr.57.4.6
doi: 10.1124/pr.57.4.6
pubmed: 16382100
Clarke LL, Harline MC (1998) Dual role of CFTR in cAMP-stimulated HCO
doi: 10.1152/ajpgi.1998.274.4.G718
pubmed: 9575854
Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F (2013) Multiplex genome engineering using CRISPR/Cas systems. Science 339:819–823. https://doi.org/10.1126/science.1231143
doi: 10.1126/science.1231143
pubmed: 23287718
pmcid: 3795411
Damkier HH, Nielsen S, Praetorius J (2006) An anti-NH2-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 290:H172–H180. https://doi.org/10.1152/ajpheart.00713.2005
doi: 10.1152/ajpheart.00713.2005
pubmed: 16126812
Daniel H, Rehner G (1986) Effect of metabolizable sugars on the mucosal surface pH of rat intestine. J Nutr 116:768–777. https://doi.org/10.1093/jn/116.5.768
doi: 10.1093/jn/116.5.768
pubmed: 3701457
De Gregorio V, Imparato G, Urciuolo F, Netti PA (2018) Micro-patterned endogenous stroma equivalent induces polarized crypt-villus architecture of human small intestinal epithelium. Acta Biomater 81:43–59. https://doi.org/10.1016/j.actbio.2018.09.061
doi: 10.1016/j.actbio.2018.09.061
pubmed: 30282052
De Vallière C, Wang Y, Eloranta JJ, Vidal S, Clay I, Spalinger MR, Tcymbarevich I, Terhalle A, Ludwig MG, Suply T, Fried M, Kullak-Ublick GA, Frey-Wagner I, Scharl M, Seuwen K, Wagner CA, Rogler G (2015) G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation. Inflamm Bowel Dis 21:1269–1281. https://doi.org/10.1097/MIB.0000000000000375
doi: 10.1097/MIB.0000000000000375
pubmed: 25856770
De Vallière C, Vida S, Clay I, Jurisic G, Tcymbarevich I, Lang S, Ludwig MG, Okoniewski M, Eloranta JJ, Kullak-Ublick GA, Wagner CA, Rogler G, Seuwen K (2015) The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment. Am J Physiol - Gastrointest Liver Physiol 309:G475–G490. https://doi.org/10.1152/ajpgi.00408.2014
doi: 10.1152/ajpgi.00408.2014
pubmed: 26206859
de Vallière C, Cosin-Roger J, Baebler K, Schoepflin A, Mamie C, Mollet M, Schuler C, Bengs S, Lang S, Scharl M, Seuwen K, Ruiz PA, Hausmann M, Rogler G (2022) pH-sensing G protein-coupled receptor OGR1 (GPR68) expression and activation increases in intestinal inflammation and fibrosis. Int J Mol Sci 23:1–20. https://doi.org/10.3390/ijms23031419
doi: 10.3390/ijms23031419
Deval E, Lingueglia E (2015) Acid-sensing ion channels and nociception in the peripheral and central nervous systems. Neuropharmacology 94:49–57. https://doi.org/10.1016/j.neuropharm.2015.02.009
doi: 10.1016/j.neuropharm.2015.02.009
pubmed: 25724084
Deval E, Gasull X, Noël J, Salinas M, Baron A, Diochot S, Lingueglia E (2010) Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacol Ther 128:549–558. https://doi.org/10.1016/j.pharmthera.2010.08.006
doi: 10.1016/j.pharmthera.2010.08.006
pubmed: 20807551
Di Meglio L, Grimaldi G, Esposito F, Gelzo M, Esposito MV, Castaldo G, Canani RB (2021) Step-up approach for sodium butyrate treatment in children with congenital chloride diarrhea. Front Pediatr 9:810765. https://doi.org/10.3389/fped.2021.810765
doi: 10.3389/fped.2021.810765
pubmed: 35127600
Ding X, Li D, Li M, Tian D, Yu H, Yu Q (2018) Tumor necrosis factor-α acts reciprocally with solute carrier family 26, member 3, (downregulated-in-adenoma) and reduces its expression, leading to intestinal inflammation. Int J Mol Med 41:1224–1232. https://doi.org/10.3892/ijmm.2017.3347
doi: 10.3892/ijmm.2017.3347
pubmed: 29286110
Dong X, Ko KH, Chow J, Tuo B, Barrett KE, Dong H (2011) Expression of acid-sensing ion channels in intestinal epithelial cells and their role in the regulation of duodenal mucosal bicarbonate secretion. Acta Physiol 201:97–107. https://doi.org/10.1111/j.1748-1716.2010.02207.x
doi: 10.1111/j.1748-1716.2010.02207.x
Dong L, Li Z, Leffler NR, Asch AS, Chi JT, Yang L V. (2013) Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. PLoS One 8. https://doi.org/10.1371/journal.pone.0061991
El Khouri E, Touré A (2014) Functional interaction of the cystic fibrosis transmembrane conductance regulator with members of the SLC26 family of anion transporters (SLC26A8 and SLC26A9): physiological and pathophysiological relevance. Int J Biochem Cell Biol 52:58–67. https://doi.org/10.1016/j.biocel.2014.02.001
doi: 10.1016/j.biocel.2014.02.001
pubmed: 24530837
Feil W, Lacy ER, Wong YM, Burger D, Wenzl E, Starlinger M, Schiessel R (1989) Rapid epithelial restitution of human and rabbit colonic mucosa. Gastroenterology 97:685–701. https://doi.org/10.1016/0016-5085(89)90640-9
doi: 10.1016/0016-5085(89)90640-9
pubmed: 2753329
Fiddian-Green RG, Silen W (1975) Mechanisms of disposal of acid and alkali in rabbit duodenum. Am J Physiol 229:1641–1648. https://doi.org/10.1152/ajplegacy.1975.229.6.1641
doi: 10.1152/ajplegacy.1975.229.6.1641
pubmed: 2019
Flemström G, Sachs TG (1975) Ion transport by amphibian antrum in vitro. I General characteristics Am J Physiol 228:1188–1198. https://doi.org/10.1152/ajplegacy.1975.228.4.1188
doi: 10.1152/ajplegacy.1975.228.4.1188
pubmed: 236668
Fordtran JS, Rector FC, Carter NW (1968) The mechanisms of sodium absorption in the human small intestine. J Clin Invest 47:884–900. https://doi.org/10.1172/JCI105781
doi: 10.1172/JCI105781
pubmed: 5641624
pmcid: 297237
Freel RW, Hatch M, Green M, Soleimani M (2006) Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice. Am J Physiol Gastrointest Liver Physiol 290:G719–G728. https://doi.org/10.1152/ajpgi.00481.2005
doi: 10.1152/ajpgi.00481.2005
pubmed: 16373425
Freel RW, Morozumi M, Hatch M (2009) Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1. Am J Physiol Gastrointest Liver Physiol 297:G918–G929. https://doi.org/10.1152/ajpgi.00251.2009
doi: 10.1152/ajpgi.00251.2009
pubmed: 20501439
pmcid: 2777456
Fujii T, Sato M, Hosoi K, Ohbayashi N, Ikuse T, Jimbo K, Aoyagi Y, Kudo T, Ohtsuka Y, Shimizu T (2016) Assessment of the family history of patients with ulcerative colitis at a single center in Japan. J Pediatr Gastroenterol Nutr 63:512–515. https://doi.org/10.1097/MPG.0000000000001275
doi: 10.1097/MPG.0000000000001275
pubmed: 27352080
Gawenis LR, Bradford EM, Prasad V, Lorenz JN, Simpson JE, Clarke LL, Woo AL, Grisham C, Sanford LP, Doetschman T, Miller ML, Shull GE (2007) Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na
doi: 10.1074/jbc.M607041200
pubmed: 17192275
Gelfond D, Ma C, Semler J, Borowitz D (2013) Intestinal pH and gastrointestinal transit profiles in cystic fibrosis patients measured by wireless motility capsule. Dig Dis Sci 58:2275–2281. https://doi.org/10.1007/s10620-012-2209-1
doi: 10.1007/s10620-012-2209-1
pubmed: 22592630
Gelfond D, Heltshe S, Ma C, Rowe SM, Frederick C, Uluer A, Sicilian L, Konstan M, Tullis E, Roach RNC, Griffin K, Joseloff E, Borowitz D (2017) Impact of CFTR modulation on intestinal pH, motility, and clinical outcomes in patients with cystic fibrosis and the G551D mutation. Clin Transl Gastroenterol 8:e81. https://doi.org/10.1038/ctg.2017.10
doi: 10.1038/ctg.2017.10
pubmed: 28300821
pmcid: 5387753
Geng W, Wang Z, Zhang J, Reed BY, Pak CYC, Moe OW (2005) Cloning and characterization of the human soluble adenylyl cyclase. Am J Physiol - Cell Physiol 288:1305–1316. https://doi.org/10.1152/ajpcell.00584.2004
doi: 10.1152/ajpcell.00584.2004
Gibbons DD, Kutschke WJ, Weiss RM, Benson CJ (2015) Heart failure induces changes in acid-sensing ion channels in sensory neurons innervating skeletal muscle. J Physiol 593:4575–4587. https://doi.org/10.1113/JP270690
doi: 10.1113/JP270690
pubmed: 26314284
pmcid: 4606529
Goldstein SAN, Bayliss DA, Kim D, Lesage F, Plant LD (2005) Nomenclature and molecular relationships of two-P potassium channels. Pharmacol Rev 57:527–540. https://doi.org/10.1124/pr.57.4.12.1
doi: 10.1124/pr.57.4.12.1
pubmed: 16382106
Guo Y, Li X, Geng C, Song S, Xie X, Wang C (2023) Vitamin D receptor involves in the protection of intestinal epithelial barrier function via up-regulating SLC26A3. J Steroid Biochem Mol Biol 227:106231. https://doi.org/10.1016/j.jsbmb.2022.106231
doi: 10.1016/j.jsbmb.2022.106231
pubmed: 36462760
Haggie PM, Cil O, Lee S, Tan J-A, Rivera AA, Phuan P-W, Verkman AS (2018) SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI insight 3. https://doi.org/10.1172/jci.insight.121370
Hayashi H, Nagai H, Ohba K-I, Soleimani M, Suzuki Y (2021) Segmental differences in Slc26a3-dependent Cl- absorption and HCO3- secretion in the mouse large intestine in vitro in Ussing chambers. J Physiol Sci 71:5. https://doi.org/10.1186/s12576-020-00784-9
doi: 10.1186/s12576-020-00784-9
pubmed: 33514305
pmcid: 10717946
Hellwig N, Plant TD, Janson W, Schäfer M, Schultz G, Schaefer M (2004) TRPV1 acts as proton channel to induce acidification in nociceptive neurons. J Biol Chem 279:34553–34561. https://doi.org/10.1074/jbc.M402966200
doi: 10.1074/jbc.M402966200
pubmed: 15173182
Heylings JR, Garner A (1981) Influence of luminal acidification on bicarbonate transport by gastric and duodenal isolated mucosae. Prostaglandins 21(Suppl):67–71. https://doi.org/10.1016/0090-6980(81)90120-9
doi: 10.1016/0090-6980(81)90120-9
pubmed: 6272370
Hogan DL, Rapier RC, Dreilinger A, Koss MA, Basuk PM, Weinstein WM, Nyberg LM, Isenberg JI (1996) Duodenal bicarbonate secretion: eradication of Helicobacter pylori and duodenal structure and function in humans. Gastroenterology 110:705–716. https://doi.org/10.1053/gast.1996.v110.pm8608879
doi: 10.1053/gast.1996.v110.pm8608879
pubmed: 8608879
Hogan DL, Crombie DL, Isenberg JI, Svendsen P, Schaffalitzky de Muckadell OB, Ainsworth MA (1997) Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice. Gastroenterology 113:533–541. https://doi.org/10.1053/gast.1997.v113.pm9247473
doi: 10.1053/gast.1997.v113.pm9247473
pubmed: 9247473
Hogan DL, Crombie DL, Isenberg JI, Svendsen P, Schaffalitzky de Muckadell OB, Ainsworth MA (1997) CFTR mediates cAMP- and Ca
doi: 10.1152/ajpgi.1997.272.4.G872
pubmed: 9142920
Höglund P, Haila S, Socha J, Tomaszewski L, Saarialho-Kere U, Karjalainen-Lindsberg ML, Airola K, Holmberg C, de la Chapelle A, Kere J (1996) Mutations of the down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. Nat Genet 14:316–319. https://doi.org/10.1038/ng1196-316
doi: 10.1038/ng1196-316
pubmed: 8896562
Holzer P (2009) Acid-sensitive ion channels and receptors. Handb Exp Pharmacol 194:283–332. https://doi.org/10.1007/978-3-540-79090-7_9
doi: 10.1007/978-3-540-79090-7_9
Holzer P (2011) Acid sensing by visceral afferent neurones. Acta Physiol 201:63–75. https://doi.org/10.1111/j.1748-1716.2010.02143.x
doi: 10.1111/j.1748-1716.2010.02143.x
Hornick RB (1987) Peptic ulcer disease: a bacterial infection? N Engl J Med 316:1598–1600. https://doi.org/10.1056/NEJM198706183162509
doi: 10.1056/NEJM198706183162509
pubmed: 3587292
Huang CW, Tzeng JN, Chen YJ, Tsai WF, Chen CC, Sun WH (2007) Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors. Mol Cell Neurosci 36:195–210. https://doi.org/10.1016/j.mcn.2007.06.010
doi: 10.1016/j.mcn.2007.06.010
pubmed: 17720533
Hug MJ, Tamada T, Bridges RJ (2003) CFTR and bicarbonate secretion by [correction of to] epithelial cells. News Physiol Sci 18:38–42. https://doi.org/10.1152/nips.01412.2002
doi: 10.1152/nips.01412.2002
pubmed: 12531931
Hug MJ, Clarke LL, Gray MA (2011) How to measure CFTR-dependent bicarbonate transport: from single channels to the intact epithelium. Methods Mol Biol 741:489–509. https://doi.org/10.1007/978-1-61779-117-8_30
doi: 10.1007/978-1-61779-117-8_30
pubmed: 21594803
Hutter S, Van Haaften WT, Hünerwadel A, Baebler K, Herfarth N, Raselli T, Mamie C, Misselwitz B, Rogler G, Weder B, Dijkstra G, Meier CF, De Vallière C, Weber A, Imenez Silva PH, Wagner CA, Frey-Wagner I, Ruiz PA, Hausmann M (2018) Intestinal activation of pH-sensing receptor OGR1 [GPR68] contributes to fibrogenesis. J Crohn’s Colitis 12:1348–1358. https://doi.org/10.1093/ecco-jcc/jjy118
doi: 10.1093/ecco-jcc/jjy118
Isenberg JI, Selling JA, Hogan DL, Koss MA (1987) Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 316:374–379. https://doi.org/10.1056/NEJM198702123160704
doi: 10.1056/NEJM198702123160704
pubmed: 3807974
Ishiguro H, Steward M, Naruse S (2007) Cystic fibrosis transmembrane conductance regulator and SLC26 transporters in HCO
pubmed: 17700966
Ishiguro H, Yamamoto A, Nakakuki M, Yi L, Ishiguro M, Yamaguchi M, Kondo S, Mochimaru Y (2012) Physiology and pathophysiology of bicarbonate secretion by pancreatic duct epithelium. Nagoya J Med Sci 74:1–18
pubmed: 22515107
pmcid: 4831246
Jacob P, Christiani S, Rossmann H, Lamprecht G, Vieillard-Baron D, Müller R, Gregor M, Seidler U (2000) Role of Na(+)HCO(3)(-) cotransporter NBC1, Na(+)/H(+) exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion. Gastroenterology 119:406–419. https://doi.org/10.1053/gast.2000.9358
doi: 10.1053/gast.2000.9358
pubmed: 10930376
Jacob P, Rossmann H, Lamprecht G, Kretz A, Neff C, Lin-Wu E, Gregor M, Groneberg DA, Kere J, Seidler U (2002) Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum. Gastroenterology 122:709–724. https://doi.org/10.1053/gast.2002.31875
doi: 10.1053/gast.2002.31875
pubmed: 11875004
Jakab RL, Collaco AM, Ameen NA (2011) Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine. Am J Physiol Gastrointest Liver Physiol 300:G82-98. https://doi.org/10.1152/ajpgi.00245.2010
doi: 10.1152/ajpgi.00245.2010
pubmed: 21030607
Jang KK, Heaney T, London M, Ding Y, Putzel G, Yeung F, Ercelen D, Chen YH, Axelrad J, Gurunathan S, Zhou C, Podkowik M, Arguelles N, Srivastava A, Shopsin B, Torres VJ, Keestra-Gounder AM, Pironti A, Griffin ME, Hang HC, Cadwell K (2023) Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization. Cell Host Microbe 31(9):1450-1468.e8
doi: 10.1016/j.chom.2023.08.002
pubmed: 37652008
Jayawardena D, Priyamvada S, Kageyama T, White Z, Kumar A, Griggs TF, Majumder A, Akram R, Anbazhagan AN, Sano T, Dudeja PK (2023) Loss of SLC26A3 results in colonic mucosal immune dysregulation via epithelial-immune cell crosstalk. Cell Mol Gastroenterol Hepatol 15:903–919. https://doi.org/10.1016/j.jcmgh.2022.12.009
doi: 10.1016/j.jcmgh.2022.12.009
pubmed: 36535508
Jiang Z, Grichtchenko II, Boron WF, Aronson PS (2002) Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem 277:33963–33967. https://doi.org/10.1074/jbc.M202660200
doi: 10.1074/jbc.M202660200
pubmed: 12119287
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E (2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337:816–821. https://doi.org/10.1126/science.1225829
doi: 10.1126/science.1225829
pubmed: 22745249
pmcid: 6286148
Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J (2013) RNA-programmed genome editing in human cells. Elife 2:e00471. https://doi.org/10.7554/eLife.00471
doi: 10.7554/eLife.00471
pubmed: 23386978
pmcid: 3557905
Jordt SE, Tominaga M, Julius D (2000) Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A 97:8134–8139. https://doi.org/10.1073/pnas.100129497
doi: 10.1073/pnas.100129497
pubmed: 10859346
pmcid: 16682
Juric M, Xiao F, Amasheh S, May O, Wahl K, Bantel H, Manns MP, Seidler U, Bachmann O (2013) Increased epithelial permeability is the primary cause for bicarbonate loss in inflamed murine colon. Inflamm Bowel Dis 19:904–911. https://doi.org/10.1097/MIB.0b013e3182813322
doi: 10.1097/MIB.0b013e3182813322
pubmed: 23502355
Kamenetsky M, Middelhaufe S, Bank EM, Levin LR, Buck J, Steegborn C (2006) Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol 362:623–639. https://doi.org/10.1016/j.jmb.2006.07.045
doi: 10.1016/j.jmb.2006.07.045
pubmed: 16934836
pmcid: 3662476
Karb DB, Cummings LC (2021) The intestinal microbiome and cystic fibrosis transmembrane conductance regulator modulators: emerging themes in the management of gastrointestinal manifestations of cystic fibrosis. Curr Gastroenterol Rep 23:17. https://doi.org/10.1007/s11894-021-00817-2
doi: 10.1007/s11894-021-00817-2
pubmed: 34448955
Kawamata K, Hayashi H, Suzuki Y (2006) Chloride-dependent bicarbonate secretion in the mouse large intestine. Biomed Res 27:15–21. https://doi.org/10.2220/biomedres.27.15
doi: 10.2220/biomedres.27.15
pubmed: 16543661
Kere J, Sistonen P, Holmberg C, de la Chapelle A (1993) The gene for congenital chloride diarrhea maps close to but is distinct from the gene for cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A 90:10686–10689. https://doi.org/10.1073/pnas.90.22.10686
doi: 10.1073/pnas.90.22.10686
pubmed: 7504277
pmcid: 47842
Kim Y, Jun I, Shin DH, Yoon JG, Piao H, Jung J, Park HW, Cheng MH, Bahar I, Whitcomb DC, Lee MG (2020) Regulation of CFTR bicarbonate channel activity by WNK1: implications for pancreatitis and CFTR-related disorders. Cell Mol Gastroenterol Hepatol 9:79–103. https://doi.org/10.1016/j.jcmgh.2019.09.003
doi: 10.1016/j.jcmgh.2019.09.003
pubmed: 31561038
Kini A, Singh AK, Riederer B, Yang I, Tan X, di Stefano G, Tan Q, Xiao F, Xia W, Suerbaum S, Seidler U (2020) Slc26a3 deletion alters pH-microclimate, mucin biosynthesis, microbiome composition and increases the TNFα expression in murine colon. Acta Physiol 230:e13498. https://doi.org/10.1111/apha.13498
doi: 10.1111/apha.13498
Kini A, Zhao B, Basic M, Roy U, Iljazovic A, Odak I, Ye Z, Riederer B, Di Stefano G, Römermann D, Koenecke C, Bleich A, Strowig T, Seidler U (2022) Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect. Gut Microbes 14:2041943. https://doi.org/10.1080/19490976.2022.2041943
doi: 10.1080/19490976.2022.2041943
pubmed: 35230892
pmcid: 8890434
Knauf F, Ko N, Jiang Z, Robertson WG, Van Itallie CM, Anderson JM, Aronson PS (2011) Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol 22:2247–2255. https://doi.org/10.1681/ASN.2011040433
doi: 10.1681/ASN.2011040433
pubmed: 22021714
pmcid: 3250206
Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ (2010) Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 115:4742–4749. https://doi.org/10.1182/blood-2009-10-249540
doi: 10.1182/blood-2009-10-249540
pubmed: 20351312
pmcid: 2890190
Krishtal OA, Pidoplichko VI (1980) A receptor for protons in the nerve cell membrane. Neuroscience 5:2325–2327. https://doi.org/10.1016/0306-4522(80)90149-9
doi: 10.1016/0306-4522(80)90149-9
pubmed: 6970348
Kumar A, Priyamvada S, Ge Y, Jayawardena D, Singhal M, Anbazhagan AN, Chatterjee I, Dayal A, Patel M, Zadeh K, Saksena S, Alrefai WA, Gill RK, Zadeh M, Zhao N, Mohamadzadeh M, Dudeja PK (2021) A novel role of SLC26A3 in the maintenance of intestinal epithelial barrier integrity. Gastroenterology 160:1240-1255.e3. https://doi.org/10.1053/j.gastro.2020.11.008
doi: 10.1053/j.gastro.2020.11.008
pubmed: 33189700
Kunzelmann K, Schreiber R, Hadorn HB (2017) Bicarbonate in cystic fibrosis. J Cyst Fibros 16:653–662. https://doi.org/10.1016/j.jcf.2017.06.005
doi: 10.1016/j.jcf.2017.06.005
pubmed: 28732801
Kurita Y, Nakada T, Kato A, Doi H, Mistry AC, Chang MH, Romero MF, Hirose S (2008) Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish. Am J Physiol - Regul Integr Comp Physiol 294:1402–1412. https://doi.org/10.1152/ajpregu.00759.2007
doi: 10.1152/ajpregu.00759.2007
Lamprecht G, Baisch S, Schoenleber E, Gregor M (2005) Transport properties of the human intestinal anion exchanger DRA (down-regulated in adenoma) in transfected HEK293 cells. Pflugers Arch 449:479–490. https://doi.org/10.1007/s00424-004-1342-x
doi: 10.1007/s00424-004-1342-x
pubmed: 15480750
Lee MG, Ahn W, Lee JA, Kim JY, Choi JY, Moe OW, Milgram SL, Muallem S, Kim KH (2001) Coordination of pancreatic HCO3- secretion by protein-protein interaction between membrane transporters. JOP 2:203–206
pubmed: 11875260
Legen I, Kristl A (2003) Factors affecting the microclimate pH of the rat jejunum in ringer bicarbonate buffer. Biol Pharm Bull 26:886–889. https://doi.org/10.1248/bpb.26.886
doi: 10.1248/bpb.26.886
pubmed: 12808306
Liu X, Li T, Riederer B, Lenzen H, Ludolph L, Yeruva S, Tuo B, Soleimani M, Seidler U (2015) Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO3(-) transport and reduces survival in CFTR-deficient mice. Pflugers Arch 467:1261–1275. https://doi.org/10.1007/s00424-014-1543-x
doi: 10.1007/s00424-014-1543-x
pubmed: 24965066
Ludwig M-G, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K (2003) Proton-sensing G-protein-coupled receptors. Nature 425:93–98. https://doi.org/10.1038/nature01905
doi: 10.1038/nature01905
pubmed: 12955148
Maeyashiki C, Melhem H, Hering L, Baebler K, Cosin-Roger J, Schefer F, Weder B, Hausmann M, Scharl M, Rogler G, de Vallière C, Ruiz PA (2020) Activation of pH-sensing receptor OGR1 (GPR68) induces ER stress via the IRE1α/JNK pathway in an intestinal epithelial cell model. Sci Rep 10:1–12. https://doi.org/10.1038/s41598-020-57657-9
doi: 10.1038/s41598-020-57657-9
Magalhães D, Cabral JM, Soares-da-Silva P, Magro F (2016) Role of epithelial ion transports in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 310:G460–G476. https://doi.org/10.1152/ajpgi.00369.2015
doi: 10.1152/ajpgi.00369.2015
pubmed: 26744474
Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM (2013) RNA-guided human genome engineering via Cas9. Science 339:823–826. https://doi.org/10.1126/science.1232033
doi: 10.1126/science.1232033
pubmed: 23287722
pmcid: 3712628
Marsh R, Dos Santos C, Hanson L, Ng C, Major G, Smyth AR, Rivett D, van der Gast C (2023) Tezacaftor/ivacaftor therapy has negligible effects on the cystic fibrosis gut microbiome. Microbiol Spectr 11:e0117523. https://doi.org/10.1128/spectrum.01175-23
doi: 10.1128/spectrum.01175-23
pubmed: 37607068
Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311–1315. https://doi.org/10.1016/s0140-6736(84)91816-6
doi: 10.1016/s0140-6736(84)91816-6
pubmed: 6145023
McCole DF, Barrett KE (2003) Epithelial transport and gut barrier function in colitis. Curr Opin Gastroenterol 19:578–582. https://doi.org/10.1097/00001574-200311000-00011
doi: 10.1097/00001574-200311000-00011
pubmed: 15703608
McHugh DR, Cotton CU, Moss FJ, Vitko M, Valerio DM, Kelley TJ, Hao S, Jafri A, Drumm ML, Boron WF, Stern RC, McBennett K, Hodges CA (2018) Linaclotide improves gastrointestinal transit in cystic fibrosis mice by inhibiting sodium/hydrogen exchanger 3. Am J Physiol Gastrointest Liver Physiol 315:G868–G878. https://doi.org/10.1152/ajpgi.00261.2017
doi: 10.1152/ajpgi.00261.2017
pubmed: 30118317
pmcid: 9925117
Megalaa R, Gopalareddy V, Champion E, Goralski JL (2019) Time for a gut check: pancreatic sufficiency resulting from CFTR modulator use. Pediatr Pulmonol 54:E16–E18. https://doi.org/10.1002/ppul.24353
doi: 10.1002/ppul.24353
pubmed: 31066218
Melvin JE, Park K, Richardson L, Schultheis PJ, Shull GE (1999) Mouse down-regulated in adenoma (DRA) is an intestinal Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na(+)/H(+) exchanger. J Biol Chem 274:22855–22861. https://doi.org/10.1074/jbc.274.32.22855
doi: 10.1074/jbc.274.32.22855
pubmed: 10428871
Moseley RH, Höglund P, Wu GD, Silberg DG, Haila S, de la Chapelle A, Holmberg C, Kere J (1999) Downregulated in adenoma gene encodes a chloride transporter defective in congenital chloride diarrhea. Am J Physiol 276:G185–G192. https://doi.org/10.1152/ajpgi.1999.276.1.G185
doi: 10.1152/ajpgi.1999.276.1.G185
pubmed: 9886994
Nedjadi T, Moran AW, Al-Rammahi MA, Shirazi-Beechey SP (2014) Characterization of butyrate transport across the luminal membranes of equine large intestine. Exp Physiol 99:1335–1347. https://doi.org/10.1113/expphysiol.2014.077982
doi: 10.1113/expphysiol.2014.077982
pubmed: 25172888
Nikolovska K, Tytmonas E, Seidler A, di Stefano G, Voigtländer T, Hellms T, Lenzen H, Seidler U (2023) Altered colonocyte differentiation may lead to decreased electrolyte and fluid absorption in the ileocolon of IBD patients by affecting the expression pattern of the responsible ion transporters. Physiology 38. https://doi.org/10.1152/physiol.2023.38.S1.5732076
Norsa L, Berni Canani R, Duclaux-Loras R, Bequet E, Köglmeier J, Russell RK, Uhlig HH, Travis S, Hollis J, Koletzko S, Grimaldi G, Castaldo G, Rodrigues A, Deflandre J, Dembinski L, Shah N, Heinz-Erian P, Janecke A, Leskinen S, Wedenoja S, Koskela R, Lachaux A, Kolho K-L, Ruemmele FM (2021) Inflammatory bowel disease in patients with congenital chloride diarrhoea. J Crohns Colitis 15:1679–1685. https://doi.org/10.1093/ecco-jcc/jjab056
doi: 10.1093/ecco-jcc/jjab056
pubmed: 33770165
Nugent SG, Kumar D, Rampton DS, Evans DF (2001) Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Gut 48:571–577. https://doi.org/10.1136/gut.48.4.571
doi: 10.1136/gut.48.4.571
pubmed: 11247905
pmcid: 1728243
Ohana E, Yang D, Shcheynikov N, Muallem S (2009) Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol 587:2179–2185. https://doi.org/10.1113/jphysiol.2008.164863
doi: 10.1113/jphysiol.2008.164863
pubmed: 19015189
Okamura N, Tajima Y, Soejima A, Masuda H, Sugita Y (1985) Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase. J Biol Chem 260:9699–9705. https://doi.org/10.1016/s0021-9258(17)39295-5
doi: 10.1016/s0021-9258(17)39295-5
pubmed: 2991260
Page AJ, Brierley SM, Martin CM, Price MP, Symonds E, Butler R, Wemmie JA, Blackshaw LA (2005) Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut 54:1408–1415. https://doi.org/10.1136/gut.2005.071084
doi: 10.1136/gut.2005.071084
pubmed: 15987792
pmcid: 1774697
Palazon A, Goldrath AW, Nizet V, Johnson RS (2014) HIF transcription factors, inflammation, and immunity. Immunity 41:518–528. https://doi.org/10.1016/j.immuni.2014.09.008
doi: 10.1016/j.immuni.2014.09.008
pubmed: 25367569
pmcid: 4346319
Park HW, Nam JH, Kim JY, Namkung W, Yoon JS, Lee J-S, Kim KS, Venglovecz V, Gray MA, Kim KH, Lee MG (2010) Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion. Gastroenterology 139:620–631. https://doi.org/10.1053/j.gastro.2010.04.004
doi: 10.1053/j.gastro.2010.04.004
pubmed: 20398666
Patterson LM, Zheng H, Ward SM, Berthoud HR (2003) Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract. Cell Tissue Res 311:277–287. https://doi.org/10.1007/s00441-002-0682-0
doi: 10.1007/s00441-002-0682-0
pubmed: 12658436
Pavlov I (1904) Nobel lecture. NobelPrize.org. Nobel Prize Outreach AB 2023. https://www.nobelprize.org/prizes/medicine/1904/pavlov/lecture/ . 13 Nov 2023
Poulsen JH, Fischer H, Illek B, Machen TE (1994) Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A 91:5340–5344. https://doi.org/10.1073/pnas.91.12.5340
doi: 10.1073/pnas.91.12.5340
pubmed: 7515498
pmcid: 43990
Press AG, Hauptmann IA, Hauptmann L, Fuchs B, Fuchs M, Ewe K, Ramadori G (1998) Gastrointestinal pH profiles in patients with inflammatory bowel disease. Aliment Pharmacol Ther 12:673–678. https://doi.org/10.1046/j.1365-2036.1998.00358.x
doi: 10.1046/j.1365-2036.1998.00358.x
pubmed: 9701532
Priyamvada S, Anbazhagan AN, Kumar A, Chatterjee I, Borthakur A, Saksena S, Gill RK, Alrefai WA, Dudeja PK (2020) All-trans retinoic acid counteracts diarrhea and inhibition of downregulated in adenoma expression in gut inflammation. Inflamm Bowel Dis 26:534–545. https://doi.org/10.1093/ibd/izz249
doi: 10.1093/ibd/izz249
pubmed: 31634391
Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON (2005) Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A 102:1632–1637. https://doi.org/10.1073/pnas.0409415102
doi: 10.1073/pnas.0409415102
pubmed: 15665078
pmcid: 545089
Riegler M, Feil W, Wenzl E, Schiessel R (1991) Factors influencing the restitution of the duodenal and colonic mucosa after damage. J Physiol Pharmacol 42:61–71
pubmed: 1932774
Romero MF, Chang M-H, Plata C, Zandi-Nejad K, Mercado A, Broumand V, Sussman CR, Mount DB (2006) Physiology of electrogenic SLC26 paralogues. Novartis Found Symp 273:126–38
doi: 10.1002/0470029579.ch9
pubmed: 17120765
Romero MF, Chen AP, Parker MD, Boron WF (2013) The SLC4 family of bicarbonate (HCO3-) transporters. Mol Aspects Med 34:159–182. https://doi.org/10.1016/j.mam.2012.10.008
doi: 10.1016/j.mam.2012.10.008
pubmed: 23506864
pmcid: 3605756
Roussa E, Alper SL, Thévenod F (2001) Immunolocalization of anion exchanger AE2, Na(+)/H(+) exchangers NHE1 and NHE4, and vacuolar type H(+)-ATPase in rat pancreas. J Histochem Cytochem 49:463–474. https://doi.org/10.1177/002215540104900406
doi: 10.1177/002215540104900406
pubmed: 11259449
Sabbatini ME, Gorelick F, Glaser S (2014) Adenylyl cyclases in the digestive system. Cell Signal 26:1173–1181. https://doi.org/10.1016/j.cellsig.2014.01.033
doi: 10.1016/j.cellsig.2014.01.033
pubmed: 24521753
pmcid: 4441802
Saint-Criq V, Haq IJ, Gardner AI, Garnett JP, Ward C, Brodlie M, Gray MA (2019) Real-time, semi-automated fluorescent measurement of the airway surface liquid pH of primary human airway epithelial cells. J Vis Exp. https://doi.org/10.3791/59815
doi: 10.3791/59815
pubmed: 31259916
Salari A, Zhou K, Nikolovska K, Seidler U, Amiri M (2023) Human colonoid-myofibroblast coculture for study of apical Na
Sanderlin EJ, Leffler NR, Lertpiriyapong K, Cai Q, Hong H, Bakthavatchalu V, Fox JG, Oswald JZ, Justus CR, Krewson EA, O’Rourke D, Yang LV (2017) GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis. Biochim Biophys Acta - Mol Basis Dis 1863:569–584. https://doi.org/10.1016/j.bbadis.2016.12.005
doi: 10.1016/j.bbadis.2016.12.005
pubmed: 27940273
Sanderlin EJ, Marie M, Velcicky J, Loetscher P, Yang LV (2019) Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model. Eur J Pharmacol 852:218–230. https://doi.org/10.1016/j.ejphar.2019.03.038
doi: 10.1016/j.ejphar.2019.03.038
pubmed: 30930250
pmcid: 6526936
Sarthi JB, Trumbull AM, Abazari SM, van Unen V, Chan JE, Joo NS, Jiang Y, Kuo CJ, Sellers ZM (2023) Critical role of down-regulated in adenoma bicarbonate transporter in linaclotide stimulated intestinal bicarbonate secretion. bioRxiv Prepr Serv Biol 315:G868. https://doi.org/10.1101/2023.05.05.539132
doi: 10.1101/2023.05.05.539132
Sato T, Clevers H (2013) Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340:1190–1194. https://doi.org/10.1126/science.1234852
doi: 10.1126/science.1234852
pubmed: 23744940
Schultheiss G, Hörger S, Diener M (1998) The bumetanide-resistant part of forskolin-induced anion secretion in rat colon. Acta Physiol Scand 164:219–228
pubmed: 9805109
Schweinfest CW, Henderson KW, Suster S, Kondoh N, Papas TS (1993) Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas. Proc Natl Acad Sci U S A 90:4166–4170. https://doi.org/10.1073/pnas.90.9.4166
doi: 10.1073/pnas.90.9.4166
pubmed: 7683425
pmcid: 46467
Schweinfest CW, Spyropoulos DD, Henderson KW, Kim J-H, Chapman JM, Barone S, Worrell RT, Wang Z, Soleimani M (2006) slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. J Biol Chem 281:37962–37971. https://doi.org/10.1074/jbc.M607527200
doi: 10.1074/jbc.M607527200
pubmed: 17001077
Seidler UE (2013) Gastrointestinal HCO3- transport and epithelial protection in the gut: new techniques, transport pathways and regulatory pathways. Curr Opin Pharmacol 13:900–908. https://doi.org/10.1016/j.coph.2013.10.001
doi: 10.1016/j.coph.2013.10.001
pubmed: 24280619
Seidler U, Nikolovska K (2019) Slc26 family of anion transporters in the gastrointestinal tract: expression, function, regulation, and role in disease. Compr Physiol 9:839–872. https://doi.org/10.1002/cphy.c180027
doi: 10.1002/cphy.c180027
pubmed: 30873581
Seidler U, Blumenstein I, Kretz A, Viellard-Baron D, Rossmann H, Colledge WH, Evans M, Ratcliff R, Gregor M (1997) A functional CFTR protein is required for mouse intestinal cAMP-, cGMP- and Ca(2+)-dependent HCO3- secretion. J Physiol 505(2):411–23. https://doi.org/10.1111/j.1469-7793.1997.411bb.x
doi: 10.1111/j.1469-7793.1997.411bb.x
pubmed: 9423183
pmcid: 1160074
Seidler U, Lenzen H, Cinar A, Tessema T, Bleich A, Riederer B (2006) Molecular mechanisms of disturbed electrolyte transport in intestinal inflammation. Ann N Y Acad Sci 1072:262–275. https://doi.org/10.1196/annals.1326.024
doi: 10.1196/annals.1326.024
pubmed: 17057206
Seidler U, Rottinghaus I, Hillesheim J, Chen M, Riederer B, Krabbenhöft A, Engelhardt R, Wiemann M, Wang Z, Barone S, Manns MP, Soleimani M (2008) Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice. Pflugers Arch 455:757–766. https://doi.org/10.1007/s00424-007-0318-z
doi: 10.1007/s00424-007-0318-z
pubmed: 17763866
Sellers ZM, Childs D, Chow JYC, Smith AJ, Hogan DL, Isenberg JI, Dong H, Barrett KE, Pratha VS (2005) Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway. Am J Physiol Gastrointest Liver Physiol 288:G654–G663. https://doi.org/10.1152/ajpgi.00386.2004
doi: 10.1152/ajpgi.00386.2004
pubmed: 15513951
Shao X-X, Lin D-P, Sun L, Wu C-Q, Yang W, Jiang Y (2018) Association of ulcerative colitis with solute-linked carrier family 26 member A3 gene polymorphisms and its expression in colonic tissues in Chinese patients. Int J Colorectal Dis 33:1169–1172. https://doi.org/10.1007/s00384-018-3097-4
doi: 10.1007/s00384-018-3097-4
pubmed: 29855681
Shcheynikov N, Wang Y, Park M, Ko SBH, Dorwart M, Naruse S, Thomas PJ, Muallem S (2006) Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol 127:511–524. https://doi.org/10.1085/jgp.200509392
doi: 10.1085/jgp.200509392
pubmed: 16606687
pmcid: 2151520
Simpson JE, Schweinfest CW, Shull GE, Gawenis LR, Walker NM, Boyle KT, Soleimani M, Clarke LL (2007) PAT-1 (Slc26a6) is the predominant apical membrane Cl
doi: 10.1152/ajpgi.00354.2006
pubmed: 17170027
Simpson JE, Walker NM, Supuran CT, Soleimani M, Clarke LL (2010) Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium. Am J Physiol Gastrointest Liver Physiol 298:G683–G691. https://doi.org/10.1152/ajpgi.00293.2009
doi: 10.1152/ajpgi.00293.2009
pubmed: 20150244
pmcid: 2867431
Simson JN, Merhav A, Silen W (1981) Alkaline secretion by amphibian duodenum I General characteristics. Am J Physiol 240:G401–G408. https://doi.org/10.1152/ajpgi.1981.240.5.G401
doi: 10.1152/ajpgi.1981.240.5.G401
pubmed: 6263107
Singh AK, Sjöblom M, Zheng W, Krabbenhöft A, Riederer B, Rausch B, Manns MP, Soleimani M, Seidler U (2008) CFTR and its key role in in vivo resting and luminal acid-induced duodenal HCO3- secretion. Acta Physiol (Oxf) 193:357–365. https://doi.org/10.1111/j.1748-1716.2008.01854.x
doi: 10.1111/j.1748-1716.2008.01854.x
pubmed: 18363901
Singh AK, Amlal H, Haas PJ, Dringenberg U, Fussell S, Barone SL, Engelhardt R, Zuo J, Seidler U, Soleimani M (2008) Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int 74:438–447. https://doi.org/10.1038/ki.2008.184
doi: 10.1038/ki.2008.184
pubmed: 18496516
Singh AK, Riederer B, Chen M, Xiao F, Krabbenhöft A, Engelhardt R, Nylander O, Soleimani M, Seidler U (2010) The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function. Am J Physiol Cell Physiol 298:C1057–C1065. https://doi.org/10.1152/ajpcell.00454.2009
doi: 10.1152/ajpcell.00454.2009
pubmed: 20164375
pmcid: 2867396
Singh AK, Xia W, Riederer B, Juric M, Li J, Zheng W, Cinar A, Xiao F, Bachmann O, Song P, Praetorius J, Aalkjaer C, Seidler U (2013) Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo. J Physiol 591:2189–2204. https://doi.org/10.1113/jphysiol.2012.247874
doi: 10.1113/jphysiol.2012.247874
pubmed: 23401617
pmcid: 3634528
Sisignano M, Fischer MJM, Geisslinger G (2021) Proton-sensing GPCRs in health and disease. Cells 10. https://doi.org/10.3390/cells10082050
Sivaprakasam S, Bhutia YD, Yang S, Ganapathy V (2017) Short-chain fatty acid transporters: role in colonic homeostasis. Compr Physiol 8:299–314. https://doi.org/10.1002/cphy.c170014
doi: 10.1002/cphy.c170014
pubmed: 29357130
pmcid: 6019286
Sjöblom M, Singh AK, Zheng W, Wang J, Tuo B, Krabbenhöft A, Riederer B, Gros G, Seidler U (2009) Duodenal acidity “sensing” but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci U S A 106:13094–13099. https://doi.org/10.1073/pnas.0901488106
doi: 10.1073/pnas.0901488106
pubmed: 19622732
pmcid: 2722266
Storozhuk M, Cherninskyi A, Maximyuk O, Isaev D, Krishtal O (2021) Acid-sensing ion channels: focus on physiological and some pathological roles in the brain. Curr Neuropharmacol 19:1570–1589. https://doi.org/10.2174/1570159x19666210125151824
doi: 10.2174/1570159x19666210125151824
pubmed: 33550975
pmcid: 8762183
Stumpff F (2018) A look at the smelly side of physiology: transport of short chain fatty acids. Pflugers Arch 470(4):571–598
doi: 10.1007/s00424-017-2105-9
pubmed: 29305650
Sugiura T, Dang K, Lamb K, Bielefeldt K, Gebhart GF (2005) Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach. J Neurosci 25:2617–2627. https://doi.org/10.1523/JNEUROSCI.2894-04.2005
doi: 10.1523/JNEUROSCI.2894-04.2005
pubmed: 15758172
pmcid: 6725180
Talbot C, Lytle C (2010) Segregation of Na/H exchanger-3 and Cl/HCO
doi: 10.1152/ajpgi.00151.2010
pubmed: 20466943
Tan Q, di Stefano G, Tan X, Renjie X, Römermann D, Talbot SR, Seidler UE (2021) Inhibition of Na+ /H+ exchanger isoform 3 improves gut fluidity and alkalinity in cystic fibrosis transmembrane conductance regulator-deficient and F508del mutant mice. Br J Pharmacol 178:1018–1036. https://doi.org/10.1111/bph.15323
doi: 10.1111/bph.15323
pubmed: 33179259
Tan X, Kini A, Römermann D, Seidler U (2022) The NHE3 inhibitor tenapanor prevents intestinal obstructions in CFTR-deleted mice. Int J Mol Sci 23. https://doi.org/10.3390/ijms23179993
Tang L, Fatehi M, Linsdell P (2009) Mechanism of direct bicarbonate transport by the CFTR anion channel. J Cyst Fibros 8:115–121. https://doi.org/10.1016/j.jcf.2008.10.004
doi: 10.1016/j.jcf.2008.10.004
pubmed: 19019741
Thompson CA, DeLaForest A, Battle MA (2018) Patterning the gastrointestinal epithelium to confer regional-specific functions. Dev Biol 435:97–108. https://doi.org/10.1016/j.ydbio.2018.01.006
doi: 10.1016/j.ydbio.2018.01.006
pubmed: 29339095
pmcid: 6615902
Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531–543. https://doi.org/10.1016/S0896-6273(00)80564-4
doi: 10.1016/S0896-6273(00)80564-4
pubmed: 9768840
Tresguerres M, Levin LR, Buck J, Grosell M (2010) Modulation of NaCl absorption by [HCO
doi: 10.1152/ajpregu.00761.2009
Tse C-M, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M (2019) cAMP stimulates SLC26A3 activity in human colon by a CFTR-dependent mechanism that does not require CFTR activity. Cell Mol Gastroenterol Hepatol 7:641–653. https://doi.org/10.1016/j.jcmgh.2019.01.002
doi: 10.1016/j.jcmgh.2019.01.002
pubmed: 30659943
pmcid: 6438990
Tuo B, Riederer B, Wang Z, Colledge WH, Soleimani M, Seidler U (2006) Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion. Gastroenterology 130:349–358. https://doi.org/10.1053/j.gastro.2005.10.017
doi: 10.1053/j.gastro.2005.10.017
pubmed: 16472591
Turnberg LA (1971) Abnormalities in intestinal electrolyte transport in congenital chloridorrhoea. Gut 12:544–551. https://doi.org/10.1136/gut.12.7.544
doi: 10.1136/gut.12.7.544
pubmed: 5559143
pmcid: 1411855
Turnberg LA, Fordtran JS, Carter NW, Rector FC (1970) Mechanism of bicarbonate absorption and its relationship to sodium transport in the human jejunum. J Clin Invest 49:548–556. https://doi.org/10.1172/JCI106265
doi: 10.1172/JCI106265
pubmed: 5415681
pmcid: 322503
Umesaki Y, Yajima T, Yokokura T, Mutai M (1979) Effect of organic acid absorption on bicarbonate transport in rat colon. Pflugers Arch 379:43–47. https://doi.org/10.1007/BF00622903
doi: 10.1007/BF00622903
pubmed: 34824
Vann KT, Xiong ZG (2018) Acid-sensing ion channel 1 contributes to normal olfactory function. Behav Brain Res 337:246–251. https://doi.org/10.1016/j.bbr.2017.09.014
doi: 10.1016/j.bbr.2017.09.014
pubmed: 28912013
Vidyasagar S, Barmeyer C, Geibel J, Binder HJ, Rajendran VM (2005) Role of short-chain fatty acids in colonic HCO(3) secretion. Am J Physiol Gastrointest Liver Physiol 288:G1217–G1226. https://doi.org/10.1152/ajpgi.00415.2004
doi: 10.1152/ajpgi.00415.2004
pubmed: 15677553
Visconti PE, Muschietti JP, Flawia MM, Tezon JG (1990) Bicarbonate dependence of cAMP accumulation induced by phorbol esters in hamster spermatozoa. BBA - Mol Cell Res 1054:231–236. https://doi.org/10.1016/0167-4889(90)90246-A
doi: 10.1016/0167-4889(90)90246-A
Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M (1997) A proton-gated cation channel involved in acid-sensing. Nature 386:173–177. https://doi.org/10.1038/386173a0
doi: 10.1038/386173a0
pubmed: 9062189
Walker NM, Simpson JE, Levitt RC, Boyle KT, Clarke LL (2006) Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome. J Pharmacol Exp Ther 317:275–283. https://doi.org/10.1124/jpet.105.094847
doi: 10.1124/jpet.105.094847
pubmed: 16354791
Walker NM, Simpson JE, Brazill JM, Gill RK, Dudeja PK, Schweinfest CW, Clarke LL (2009) Role of down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum. Gastroenterology 136:893–901. https://doi.org/10.1053/j.gastro.2008.11.016
doi: 10.1053/j.gastro.2008.11.016
pubmed: 19121635
Walker NM, Simpson JE, Hoover EE, Brazill JM, Schweinfest CW, Soleimani M, Clarke LL (2011) Functional activity of Pat-1 (Slc26a6) Cl(−)/HCO
doi: 10.1111/j.1748-1716.2010.02210.x
Wang Z, Petrovic S, Mann E, Soleimani M (2002) Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine. Am J Physiol Gastrointest Liver Physiol 282:G573–G579. https://doi.org/10.1152/ajpgi.00338.2001
doi: 10.1152/ajpgi.00338.2001
pubmed: 11842009
Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, Lorenz JN, Seidler U, Aronson PS, Soleimani M (2005) Renal and intestinal transport defects in Slc26a6-null mice. Am J Physiol Cell Physiol 288:C957–C965. https://doi.org/10.1152/ajpcell.00505.2004
doi: 10.1152/ajpcell.00505.2004
pubmed: 15574486
Wang Y, Soyombo AA, Shcheynikov N, Zeng W, Dorwart M, Marino CR, Thomas PJ, Muallem S (2006) Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO
doi: 10.1038/sj.emboj.7601387
pubmed: 17053783
pmcid: 1630422
Wang Y, de Vallière C, Imenez Silva PH, Leonardi I, Gruber S, Gerstgrasser A, Melhem H, Weber A, Leucht K, Wolfram L, Hausmann M, Krieg C, Thomasson K, Boyman O, Frey-Wagner I, Rogler G, Wagner CA (2018) The proton-activated receptor GPR4 modulates intestinal inflammation. J Crohn’s Colitis 12:355–369. https://doi.org/10.1093/ecco-jcc/jjx147
doi: 10.1093/ecco-jcc/jjx147
Wang Y, Huang X, Zhou G, Han J, Xie Z, Zhang M, Li X, Wu Q-R, Li L, Ye Z, Chen M, Qiu Y, Zhang S (2023) A novel nomogram combining mucus barrier index for predicting treatment failures in ulcerative colitis. J Inflamm Res 16:1879–1894. https://doi.org/10.2147/JIR.S410057
doi: 10.2147/JIR.S410057
pubmed: 37152865
pmcid: 10162100
Wedenoja S, Pekansaari E, Höglund P, Mäkelä S, Holmberg C, Kere J (2011) Update on SLC26A3 mutations in congenital chloride diarrhea. Hum Mutat 32:715–722. https://doi.org/10.1002/humu.21498
doi: 10.1002/humu.21498
pubmed: 21394828
Wedenoja S, Saarikivi A, Mälkönen J, Leskinen S, Lehto M, Adeshara K, Tuokkola J, Nikkonen A, Merras-Salmio L, Höyhtyä M, Hörkkö S, Haaramo A, Salonen A, de Vos WM, Korpela K, Kolho K-L (2022) Fecal microbiota in congenital chloride diarrhea and inflammatory bowel disease. PLoS ONE 17:e0269561. https://doi.org/10.1371/journal.pone.0269561
doi: 10.1371/journal.pone.0269561
pubmed: 35679312
pmcid: 9182261
Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH, Welsh MJ (2002) The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 34:463–477. https://doi.org/10.1016/S0896-6273(02)00661-X
doi: 10.1016/S0896-6273(02)00661-X
pubmed: 11988176
Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ (2004) Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A 101:3621–3626. https://doi.org/10.1073/pnas.0308753101
doi: 10.1073/pnas.0308753101
pubmed: 14988500
pmcid: 373512
Wemmie JA, Price MP, Welsh MJ (2006) Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci 29:578–586. https://doi.org/10.1016/j.tins.2006.06.014
doi: 10.1016/j.tins.2006.06.014
pubmed: 16891000
Wilson RW, Wilson JM, Grosell M (2002) Intestinal bicarbonate secretion by marine teleost fish - why and how? Biochim Biophys Acta - Biomembr 1566:182–193. https://doi.org/10.1016/S0005-2736(02)00600-4
doi: 10.1016/S0005-2736(02)00600-4
Xia W, Yu Q, Riederer B, Singh AK, Engelhardt R, Yeruva S, Song P, Tian D-A, Soleiman M, Seidler U (2014) The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine. Pflugers Arch 466:1541–1556. https://doi.org/10.1007/s00424-013-1381-2
doi: 10.1007/s00424-013-1381-2
pubmed: 24233434
Xiao F, Li J, Singh AK, Riederer B, Wang J, Sultan A, Park H, Lee MG, Lamprecht G, Scholte BJ, De Jonge HR, Seidler U (2012) Rescue of epithelial HCO3- secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del. J Physiol 590:5317–5334. https://doi.org/10.1113/jphysiol.2012.232124
doi: 10.1113/jphysiol.2012.232124
pubmed: 22802588
pmcid: 3515821
Xiao F, Juric M, Li J, Riederer B, Yeruva S, Singh AK, Zheng L, Glage S, Kollias G, Dudeja P, Tian D-A, Xu G, Zhu J, Bachmann O, Seidler U (2012) Loss of downregulated in adenoma (DRA) impairs mucosal HCO3(-) secretion in murine ileocolonic inflammation. Inflamm Bowel Dis 18:101–111. https://doi.org/10.1002/ibd.21744
doi: 10.1002/ibd.21744
pubmed: 21557395
Xiao F, Yu Q, Li J, Johansson MEV, Singh AK, Xia W, Riederer B, Engelhardt R, Montrose M, Soleimani M, Tian DA, Xu G, Hansson GC, Seidler U (2014) Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice. Acta Physiol (Oxf) 211:161–175. https://doi.org/10.1111/apha.12220
doi: 10.1111/apha.12220
pubmed: 24373192
Xue H-H, Li J-J, Li S-F, Guo J, Yan R-P, Chen T-G, Shi X-H, Wang J-D, Zhang L-W (2023) Phillygenin attenuated colon inflammation and improved intestinal mucosal barrier in DSS-induced colitis mice via TLR4/Src mediated MAPK and NF-κB signaling pathways. Int J Mol Sci 24. https://doi.org/10.3390/ijms24032238
Yamaguchi M, Steward MC, Smallbone K, Sohma Y, Yamamoto A, Ko SBH, Kondo T, Ishiguro H (2017) Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium. J Physiol 595:1947–1972. https://doi.org/10.1113/JP273306
doi: 10.1113/JP273306
pubmed: 27995646
pmcid: 5350461
Yang D, Shcheynikov N, Zeng W, Ohana E, So I, Ando H, Mizutani A, Mikoshiba K, Muallem S (2009) IRBIT coordinates epithelial fluid and HCO
doi: 10.1172/JCI36983
pubmed: 19033647
Yao CK, Burgell RE, Taylor KM, Ward MG, Friedman AB, Barrett JS, Muir JG, Gibson PR (2021) Effects of fiber intake on intestinal pH, transit, and predicted oral mesalamine delivery in patients with ulcerative colitis. J Gastroenterol Hepatol 36:1580–1589. https://doi.org/10.1111/jgh.15311
doi: 10.1111/jgh.15311
pubmed: 33091174
Yermolaieva O, Leonard AS, Schnizler MK, Abboud FM, Welsh MJ (2004) Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a. Proc Natl Acad Sci U S A 101:6752–6757. https://doi.org/10.1073/pnas.0308636100
doi: 10.1073/pnas.0308636100
pubmed: 15082829
pmcid: 404117
Yu Q (2021) Slc26a3 (DRA) in the gut: expression, function, regulation, role in infectious diarrhea and inflammatory bowel disease. Inflamm Bowel Dis 27:575–584. https://doi.org/10.1093/ibd/izaa256
doi: 10.1093/ibd/izaa256
pubmed: 32989468
Yu Q, Liu X, Liu Y, Riederer B, Li T, Tian D-A, Tuo B, Shull G, Seidler U (2016) Defective small intestinal anion secretion, dipeptide absorption, and intestinal failure in suckling NBCe1-deficient mice. Pflugers Arch 468:1419–1432. https://doi.org/10.1007/s00424-016-1836-3
doi: 10.1007/s00424-016-1836-3
pubmed: 27228994
pmcid: 4951514
Yu X, Yu M, Liu Y, Yu S (2016) TRP channel functions in the gastrointestinal tract. Semin Immunopathol 38:385–396. https://doi.org/10.1007/s00281-015-0528-y
doi: 10.1007/s00281-015-0528-y
pubmed: 26459157
Zhang N, Heruth DP, Wu W, Zhang LQ, Nsumu MN, Shortt K, Li K, Jiang X, Wang B, Friesen C, Li D-Y, Ye SQ (2019) Functional characterization of SLC26A3 c.392C>G (p.P131R) mutation in intestinal barrier function using CRISPR/CAS9-created cell models. Cell Biosci 9:40. https://doi.org/10.1186/s13578-019-0303-1
doi: 10.1186/s13578-019-0303-1
pubmed: 31114672
pmcid: 6518688
Zhang L, Zheng L, Yang X, Yao S, Wang H, An J, Jin H, Wen G, Tuo B (2022) Pathology and physiology of acid-sensitive ion channels in the digestive system (Review). Int J Mol Med 50. https://doi.org/10.3892/IJMM.2022.5150
Zippin JH, Chen Y, Nahirney P, Kamenetsky M, Wuttke MS, Fischman DA, Levin LR, Buck J (2003) Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J 17:82–84. https://doi.org/10.1096/fj.02-0598fje
doi: 10.1096/fj.02-0598fje
pubmed: 12475901