Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament.

PLGA calcium hydroxide endodontic gels intracanal medication nanoparticles

Journal

International endodontic journal
ISSN: 1365-2591
Titre abrégé: Int Endod J
Pays: England
ID NLM: 8004996

Informations de publication

Date de publication:
19 Feb 2024
Historique:
revised: 13 01 2024
received: 31 10 2023
accepted: 27 01 2024
medline: 20 2 2024
pubmed: 20 2 2024
entrez: 20 2 2024
Statut: aheadofprint

Résumé

Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH) Reproducibility of Ca(OH)₂-NPs was confirmed by obtaining the average size of the NPs, their polydispersity index, zeta potential and entrapment efficiency. Moreover, rheological studies of Ca(OH) Ca(OH) Calcium hydroxide-loaded PLGA NPs dispersed in a thermosensitive gel may constitute a suitable alternative as an intracanal antibacterial medicament.

Identifiants

pubmed: 38374518
doi: 10.1111/iej.14041
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Generalitat de Catalunya
ID : 2022 FISDU 00360
Organisme : Bosch and Gimpera Foundation
ID : F2i_PdC_2021-002
Organisme : European Regional Development Fund
ID : PROD_00141

Informations de copyright

© 2024 British Endodontic Society. Published by John Wiley & Sons Ltd.

Références

Andrews, J., Handler, R.A. & Blaisten-Barojas, E. (2020) Structure, energetics and thermodynamics of PLGA condensed phases from molecular dynamics. Polymer, 206, 122903.
Arafa, M.G., El-Kased, R.F. & Elmazar, M.M. (2018) Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents. Scientific Reports, 8(1), 13674.
Ardlin, B.I., Lindholm-Sethson, B. & Dahl, J.E. (2009) Corrosion of dental nickel-aluminum bronze with a minor gold content-mechanism and biological impact. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 88(2), 465-473.
Arias-Moliz, M.T., Baca, P., Solana, C., Toledano, M., Medina-Castillo, A.L., Toledano-Osorio, M. et al. (2021) Doxycycline-functionalized polymeric nanoparticles inhibit enterococcus faecalis biofilm formation on dentine. International Endodontic Journal, 54(3), 413-426.
Arslan, H., Topcuoglu, H.S., Saygili, G., Tuncay, O. & Altintop, Y. (2015) Effect of various intracanal medicaments on the bond strength of self-adhesive resin cement to root canal dentin. Acta Biomaterialia Odontologica Scandinavica, 1(1), 18-21.
Athanassiadis, B., Abbott, P.V. & Walsh, L.J. (2007) The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics. Australian Dental Journal, 52(1 Suppl), S64-S82.
Balto, H. (2002) An assessment of microbial coronal leakage of temporary filling materials in endodontically treated teeth. Journal of Endodontics, 28(11), 762-764.
Berrio, M.E., Jerez-Olate, C., Ramírez, J.A., Saireddy, S., González-Rocha, G., Ponce, A. et al. (2023) Novel antibacterial and biocompatible nanostructured gels based on one-step synthesis as a potential disinfectant for endodontic infection control. Journal of Endodontics, 50(1), 74-84.
Coelho, C.C., Grenho, L., Gomes, P.S., Quadros, P.A. & Fernandes, M.H. (2019) Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment. Scientific Reports, 9(1), 11050.
Crispim da Silveira, O., Bras da Silva, R., Dametto, F.R., Tavares Machado, C., Souza dos Santos, A.J. & Leite Cavalcanti, A. (2014) Učinak Otopina Za Ispiranje Korijenskih Kanala Na Mikrozateznu Snagu Vezivanja Fiberglasnih Kolčića effect of endodontic irrigating solutions on the micro push-out bond strength of a fibre glass dowel. Acta Stomatologica Croatica, 48(1), 16-24.
de Araujo Lowndes Viera, L.M., Silva, R.S., da Silva, C.C., Presgrave, O.A.F. & Boas, M.H.S.V. (2022) Comparison of the different protocols of the hen's egg test-chorioallantoic membrane (HET-CAM) by evaluating the eye irritation potential of surfactants. Toxicology in Vitro, 78, 105255.
Dumortier, G., Grossiord, J.L., Agnely, F. & Chaumeil, J.C. (2006) A review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharmaceutical Research, 23(12), 2709-2728.
Edsman, K., Carlfors, J. & Petersson, R. (1998) Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. European Journal of Pharmaceutical Sciences, 6(2), 105-112.
Elmsmari, F., González Sánchez, J.A., Duran-Sindreu, F., Belkadi, R., Espina, M., García, M.L. et al. (2021) Calcium hydroxide-loaded PLGA biodegradable nanoparticles as an intracanal medicament. International Endodontic Journal, 54(11), 2086-2098.
Esteruelas, G., Halbaut, L., García-Torra, V., Espina, M., Cano, A., Ettcheto, M. et al. (2022) Development and optimization of riluzole-loaded biodegradable nanoparticles incorporated in a mucoadhesive in situ gel for the posterior eye segment. International Journal of Pharmaceutics, 612, 121379.
Esteruelas, G., Souto, E.B., Espina, M.L. & Sánchez-López, E. (2023) Diclofenac loaded biodegradable nanoparticles as antitumoral and antiangiogenic therapy. Pharmaceutics, 15(1), 102.
Estrela, C., Rodrigues, C. & Estrela, D.A. (2001) Two methods to evaluate the antimicrobial action of calcium hydroxide paste. Journal of Endodontics, 27(12), 12-15.
Farges, J.C., Alliot-Licht, B., Renard, E., Ducret, M., Gaudin, A., Smith, A.J. et al. (2015) Dental pulp defence and repair mechanisms in dental caries. Mediators of Inflammation, 2015, 230251.
Giuliano, E., Paolino, D., Cristiano, M.C., Fresta, M. & Cosco, D. (2020) Rutin-loaded poloxamer 407-based hydrogels for in situ administration: stability profiles and rheological properties. Nanomaterials, 10(6), 1069.
Gonzalez-Pizarro, R., Carvajal-Vidal, P., Halbault Bellowa, L., Calpena, A.C., Espina, M. & García, M.L. (2019) In-situ forming gels containing fluorometholone-loaded polymeric nanoparticles for ocular inflammatory conditions. Colloids and Surfaces B: Biointerfaces, 175, 365-374.
Gonzalez-Pizarro, R., Parrotta, G., Vera, R., Sánchez-López, E., Galindo, R., Kjeldsen, F. et al. (2019) Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides. Nanomedicine, 14(23), 3089-3104.
Haapasalo, M. & Orstavik, D. (1987) In vitro infection and disinfection of dentinal tubules. Journal of Dental Research, 66(8), 1375-1379.
Heng, P.W.S. (2018) Controlled release drug delivery systems. Pharmaceutical Development and Technology, 23(9), 833.
Jain, K.K. (2020) 2059 methods in molecular biology drug delivery systems, 3rd edition. Springer, USA.
Karataş, E., Baltacı, M., Uluköylü, E. & Adıgüzel, A. (2020) Antibacterial effectiveness of calcium hydroxide alone or in combination with ibuprofen and ciprofloxacin in teeth with asymptomatic apical periodontitis: a randomized controlled clinical study. International Endodontic Journal, 53(6), 742-753.
Khan, I., Khan, M., Umar, M.N. & Deog Hwan, O. (2015) Nanobiotechnology and its applications in drug delivery system: a review. IET Nanobiotechnology, 9(6), 396-400.
Lenzi, T.L., Guglielmi, C.D.A.B., Arana-Chavez, V.E. & Raggio, D.P. (2013) Tubule density and diameter in coronal dentin from primary and permanent human teeth. Microscopy and Microanalysis, 19(6), 1445-1449.
Leveque, M., Bekhouche, M., Farges, J.-C., Aussel, A., Sy, K., Richert, R. et al. (2023) Bioactive endodontic hydrogels: from parameters to personalized medicine. International Journal of Molecular Sciences, 24(18), 14056.
Li, Z. & Guan, J. (2011) Thermosensitive hydrogels for drug delivery. Expert Opinion on Drug Delivery, 8(8), 991-1007.
Lima, R.K., Guerreiro-Tanomaru, J.M., Faria-Júnior, N.B. & Tanomaru-Filho, M. (2012) Effectiveness of calcium hydroxide-based intracanal medicaments against enterococcus Faecalis. International Endodontic Journal, 45(4), 311-316.
Mirakabad, F.S.T., Nejati-Koshki, K., Akbarzadeh, A., Yamchi, M.R., Milani, M., Zarghami, N. et al. (2014) PLGA-based nanoparticles as cancer drug delivery systems. Asian Pacific Journal of Cancer Prevention, 15(2), 517-535.
Mohammadi, Z. & Dummer, P.M.H. (2011) Properties and applications of calcium hydroxide in endodontics and dental traumatology. International Endodontic Journal, 44(8), 697-730.
Moodley, Desigar, and Amir I O Ibrahim. 2021. Nanotechnology for dentistry applications nanotechnology in endodontics. IOP Publishing, Bristol, UK.
Nagendrababu, V., Murray, P.E., Ordinola-Zapata, R., Peters, O.A., Rôças, I.N., Siqueira, J.F., Jr. et al. (2021) PRILE 2021 guidelines for reporting laboratory studies in endodontology: a consensus-based development. International Endodontic Journal, 54(9), 1482-1490.
Ng, Y.L., Mann, V. & Gulabivala, K. (2011) A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health. International Endodontic Journal, 44(7), 583-609.
Oguntebi, B.R. (1994) Dentine tubule infection and endodontic therapy implications. International Endodontic Journal, 27(4), 218-222.
Pacios, M.G., Silva, C., López, M.E. & Cecilia, M. (2012) Antibacterial action of calcium hydroxide vehicles and calcium hydroxide pastes. Journal of Investigative and Clinical Dentistry, 3(4), 264-270.
Renovato, S.R., Santana, F.R., Ferreira, J.M., Souza, J.B., Soares, C.J. & Estrela, C. (2013) Effect of calcium hydroxide and endodontic irrigants on fibre post bond strength to root canal dentine. International Endodontic Journal, 46(8), 738-746.
Ricci, E.J., Bentley, M.V.L.B., Farah, M., Bretas, R.E.S. & Marchetti, J.M. (2002) Rheological characterization of poloxamer 407 lidocaine hydrochloride gels. European Journal of Pharmaceutical Sciences, 17(3), 161-167.
Ritger, P.L. & Peppas, N.A. (1987) A simple equation for description of solute release II. Fickian and anomalous release from Swellable devices. Journal of Controlled Release, 5(1), 37-42.
Rodrigues, C.T., de Andrade, F.B., de Vasconcelos, L.R.S.M., Midena, R.Z., Pereira, T.C., Kuga, M.C. et al. (2018) Antibacterial properties of silver nanoparticles as a root canal irrigant against Enterococcus Faecalis biofilm and infected dentinal tubules. International Endodontic Journal, 51(8), 901-911.
Rodríguez Nuñez, Y.A., Castro, R.I., Arenas, F.A., López-Cabaña, Z.E., Carreño, G., Carrasco-Sánchez, V. et al. (2019) Preparation of hydrogel/silver nanohybrids mediated by tunable-size silver nanoparticles for potential antibacterial applications. Polymers, 11(4), 716.
Roig-Soriano, X., Souto, E.B., Elmsmari, F., Garcia, M.L., Espina, M., Duran-Sindreu, F. et al. (2022) Nanoparticles in endodontics disinfection: state of the art. Pharmaceutics, 14(7), 1519.
Russell, A.A., Chandler, N.P., Hauman, C., Siddiqui, A.Y. & Tompkins, G.R. (2013) The butterfly effect: an investigation of sectioned roots. Journal of Endodontics, 39(2), 208-210.
Russell, A.A., He, L.H. & Chandler, N.P. (2014) Investigation of dentin hardness in roots exhibiting the butterfly effect. Journal of Endodontics, 40(6), 842-844.
Samaha, D., Shehayeb, R. & Kyriacos, S. (2009) Modeling and comparison of dissolution profiles of diltiazem modified-release formulations. Dissolution Technologies, 16(2), 41-46.
Samiei, M., Farjami, A., Dizaj, S.M. & Lotfipour, F. (2016) Nanoparticles for antimicrobial purposes in endodontics: a systematic review of in vitro studies. Materials Science and Engineering C, 58, 1269-1278.
Sánchez-López, E., Gomes, D., Esteruelas, G. & Bonilla, L. (2020) Metal-based nanoparticles as antimicrobial agents: an overview. Nanomaterials, 10(2), 292.
Segura-Egea, J.J., Gould, K., Hakan Şen, B., Jonasson, P., Cotti, E., Mazzoni, A. et al. (2018) European Society of Endodontology Position statement: the use of antibiotics in endodontics. International Endodontic Journal, 51(1), 20-25.
Shakya, A.K., al-Sulaibi, M., Naik, R.R., Nsairat, H., Suboh, S. & Abulaila, A. (2023) Review on PLGA polymer based nanoparticles with antimicrobial properties and their application in various medical conditions or infections. Polymers, 15(17), 3597.
Shriky, B., Kelly, A., Isreb, M., Babenko, M., Mahmoudi, N., Rogers, S. et al. (2020) Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. Journal of Colloid and Interface Science, 565, 119-130.
Siqueira, J.F. & De Uzeda, M. (1996) Disinfection by calcium hydroxide pastes of dentinal tubules infected with two obligate and one facultative anaerobic bacteria. Journal of Endodontics, 22(12), 674-676.
Sirén, E.K., Kerosuo, E., Lavonius, E., Meurman, J.H. & Haapasalo, M. (2014) Ca(OH)2 application modes:in vitroalkalinity and clinical effect on bacteria. International Endodontic Journal, 47(7), 628-638.
Sjögren, U., Figdor, D., Spångberg, L. & Sundqvist, G. (1991) The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing. International Endodontic Journal, 24(3), 119-125.
Someya, T., Kinoshita, H., Harada, R., Kawada, E. & Takemoto, S. (2017) Effects of calcium hydroxide reagent on the bond strength of resin cements to root dentin and the retention force of FRC posts. Dental Materials Journal, 36(5), 630-637.
Song, W. & Ge, S. (2019) Application of antimicrobial nanoparticles in dentistry. Molecules, 24(6), 1033.
Sousa, G.D., Kishishita, J., Aquino, K.A.S., Presgrave, O.A.F., Leal, L.B. & Santana, D.P. (2017) Biopharmaceutical assessment and irritation potential of microemulsions and conventional systems containing oil from Syagrus cearensis for topical delivery of amphotericin B using alternative methods. AAPS PharmSciTech, 18(5), 1833-1842.
Sungur, D., Derya, H.A. & Purali, N. (2017) Effect of a low surface tension vehicle on the dentinal tubule penetration of calcium hydroxide and triple antibiotic paste. Journal of Endodontics, 43(3), 452-455.
Taschieri, S., del Fabbro, M., Samaranayake, L., Chang, J.W.W. & Corbella, S. (2014) Microbial invasion of dentinal tubules: a literature review and a new perspective. Journal of Investigative and Clinical Dentistry, 5(3), 163-170.
Tibúrcio-Machado, C.S., Michelon, C., Zanatta, F.B., Gomes, M.S., Marin, J.A. & Bier, C.A. (2021) The global prevalence of apical periodontitis: a systematic review and meta-analysis. International Endodontic Journal, 54(5), 712-735.
Valizadeh, H., Mohammadi, G., Ehyaei, R., Milani, M., Azhdarzadeh, M., Zakeri-Milani, P. et al. (2012) Antibacterial activity of clarithromycin loaded PLGA nanoparticles. Pharmazie, 67(1), 63-68.
Wang, Z., Shen, Y. & Haapasalo, M. (2012) Effectiveness of endodontic disinfecting solutions against young and old enterococcus faecalis biofilms in dentin canals. Journal of Endodontics, 38(10), 1376-1379.
Watt, R.P., Khatri, H. & Dibble, A.R.G. (2019) Injectability as a function of viscosity and dosing materials for subcutaneous administration. International Journal of Pharmaceutics, 554, 376-386.
Yetisgin, A.A., Cetinel, S., Zuvin, M., Kosar, A. & Kutlu, O. (2020) Therapeutic nanoparticles and their targeted delivery applications. Molecules, 25, 2193.
Yohan, D. & Devika Chithrani, B. (2014) Applications of nanoparticles in Nanomedicine. Journal of Biomedical Nanotechnology, 10(9), 2371-2392.
Zand, V., Mokhtari, H., Hasani, A. & Jabbari, G. (2017) Comparison of the penetration depth of conventional and nano-particle calcium hydroxide into dentinal tubules. Iranian Endodontic Journal, 12(3), 366-370.

Auteurs

Xavier Roig (X)

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.

Lyda Halbaut (L)

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.

Firas Elmsmari (F)

Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.

Rubén Pareja (R)

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki, Finland.

Aizea Arrien (A)

Department of Endodontics, Faculty of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain.

Fernando Duran-Sindreu (F)

Department of Endodontics, Faculty of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain.

Luis María Delgado (LM)

Bioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, Spain.

Marta Espina (M)

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain.

María Luisa García (ML)

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain.

José Antonio González Sánchez (JAG)

Department of Endodontics, Faculty of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain.

Elena Sánchez-López (E)

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain.
Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain.

Classifications MeSH