Deep learning-based BMI inference from structural brain MRI reflects brain alterations following lifestyle intervention.
MRI
biomarker
deep learning
obesity
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 Feb 2024
15 Feb 2024
Historique:
revised:
16
11
2023
received:
01
05
2023
accepted:
03
01
2024
medline:
20
2
2024
pubmed:
20
2
2024
entrez:
20
2
2024
Statut:
ppublish
Résumé
Obesity is associated with negative effects on the brain. We exploit Artificial Intelligence (AI) tools to explore whether differences in clinical measurements following lifestyle interventions in overweight population could be reflected in brain morphology. In the DIRECT-PLUS clinical trial, participants with criterion for metabolic syndrome underwent an 18-month lifestyle intervention. Structural brain MRIs were acquired before and after the intervention. We utilized an ensemble learning framework to predict Body-Mass Index (BMI) scores, which correspond to adiposity-related clinical measurements from brain MRIs. We revealed that patient-specific reduction in BMI predictions was associated with actual weight loss and was significantly higher in active diet groups compared to a control group. Moreover, explainable AI (XAI) maps highlighted brain regions contributing to BMI predictions that were distinct from regions associated with age prediction. Our DIRECT-PLUS analysis results imply that predicted BMI and its reduction are unique neural biomarkers for obesity-related brain modifications and weight loss.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e26595Subventions
Organisme : NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIMH NIH HHS
ID : 5R21MH107045
Pays : United States
Organisme : NIMH NIH HHS
ID : R03MH096321
Pays : United States
Organisme : NIMH NIH HHS
ID : K23MH087770
Pays : United States
Informations de copyright
© 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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