A significant increase in anthropometric indices during long-term follow-up of pediatric patients with celiac disease, with no endocrine disorders.
BMI
Celiac disease
Growth
Height
Measurements
Weight
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
20 Feb 2024
20 Feb 2024
Historique:
received:
01
12
2023
accepted:
06
02
2024
revised:
05
02
2024
medline:
20
2
2024
pubmed:
20
2
2024
entrez:
20
2
2024
Statut:
aheadofprint
Résumé
Celiac disease (CeD) is likely to be associated with growth impairment and poor weight gain. However, long-term growth patterns following diagnosis are poorly characterized. We evaluated long-term anthropometric changes in a large cohort of pediatric patients with CeD. A retrospective chart review of patients diagnosed with CeD between 1999 and 2018 was conducted. Demographic and clinical data were collected, and anthropometrics were analyzed from diagnosis and throughout follow-up. The study included 500 patients (59.8% females, median (IQR) age at diagnosis 5.7 (3.7-8.9) years), with a mean follow-up of 5.5 (range 1.5-16.2) years. Weight, height, and BMI Z-score-for-age (WAZ, HAZ, and BMIZ) increased significantly from a mean (± SD) of - 0.82 (± 1.21), - 0.73 (± 1.16), and - 0.32 (± 1.11) at diagnosis to - 0.41 (± 1.23), - 0.45(± 1.16), and - 0.17 (± 1.14) at last follow-up, respectively (p < 0.001 for WAZ and HAZ and p = 0.002 for BMIZ). The largest improvements were observed in patients diagnosed before 3 years of age (p < 0.01). Patients for whom the final adult height was available (n = 86) improved from HAZ mean (± SD) - 0.89 ± 1.37 at diagnosis to - 0.51 ± 1.28 at adulthood measurement, p < 0.05. Wasting was present in 19.7% and stunting in 16.4% of the cohort at diagnosis and normalized in 77.3% and 64.8%, respectively, within a median (IQR) time of 0.79 (0.42-4.24) and 2.3 (0.72-6.02) years, respectively. Gluten-free diet adherence and frequency of visits were not associated with normalization of wasting or stunting in all age groups. Conclusion: Over a long-term follow-up, pediatric patients with CeD demonstrate significant increases in weight, height, and BMI-for-age. Younger age at diagnosis is associated with greater improvement in weight and linear growth, emphasizing the importance of early diagnosis of CeD. What is Known: • Celiac disease (СeD) is likely to be associated with growth impairment and poor weight gain. • Long-term changes in anthropometric indices after diagnosis of CeD are not well characterized. What is New: • Over a long-term follow-up, pediatric patients with CeD demonstrate significant increases in weight, height, and BMI-for-age. • Young age at diagnosis is associated with larger improvement in weight and linear growth.
Identifiants
pubmed: 38376595
doi: 10.1007/s00431-024-05477-8
pii: 10.1007/s00431-024-05477-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Almallouhi E, King KS, Patel B, Wi C, Juhn YJ, Murray JA, Absah I (2017) Increasing incidence and altered presentation in a population-based study of pediatric celiac disease in North America. J Pediatr Gastroenterol Nutr 65:432–437. https://doi.org/10.1097/MPG.0000000000001532
doi: 10.1097/MPG.0000000000001532
pubmed: 28151767
pmcid: 5538895
Singh P, Arora A, Strand TA, Leffler DA, Catassi C, Green PH, Kelly CP, Ahuja V, Makharia GK (2018) Global prevalence of celiac disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol 16:823–836. https://doi.org/10.1016/j.cgh.2017.06.037
doi: 10.1016/j.cgh.2017.06.037
pubmed: 29551598
Cebolla Á, Moreno ML, Coto L, Sousa C (2018) Gluten immunogenic peptides as standard for the evaluation of potential harmful prolamin content in food and human specimen. Nutrients 10:1927. https://doi.org/10.3390/nu10121927
doi: 10.3390/nu10121927
pubmed: 30563126
pmcid: 6316305
Guandalini S, Assiri A (2014) Celiac disease: a review JAMA Pediatr 168:272–278. https://doi.org/10.1001/jamapediatrics.2013.3858
doi: 10.1001/jamapediatrics.2013.3858
pubmed: 24395055
Van Kalleveen MW, de Meij T, Plötz FB (2018) Clinical spectrum of paediatric coeliac disease: a 10-year single-centre experience. Eur J Pediatr 177:593–602. https://doi.org/10.1007/s00431-018-3103-4
doi: 10.1007/s00431-018-3103-4
pubmed: 29392394
Krauthammer A, Guz-Mark A, Zevit N, Marderfeld L, Waisbourd-Zinman O, Silbermintz A, Mozer-Glassberg Y, Nachmias Friedler V, Rozenfeld Bar Lev M, Matar M, Assa A et al (2021) age-dependent trends in the celiac disease: a tertiary center experience. J Pediatr Gastroenterol Nutr 72:894–899. https://doi.org/10.1097/MPG.0000000000003130
Assa A, Frenkel-Nir Y, Leibovici-Weissman Y, Tzur D, Afek A, Katz LH, Levi Z, Shamir R (2017) Anthropometric measures and prevalence trend in adolescents with celiac disease: a population-based study. Arch Dis Child 102:139–144. https://doi.org/10.1136/archdischild-2016-311376
doi: 10.1136/archdischild-2016-311376
pubmed: 27672134
Mearin ML, Agardh D, Antunes H, Al-Toma A, Auricchio R, Castillejo G, Catassi C, Ciacci C, Discepolo V, Dolinsek J et al (2022) ESPGHAN position paper on management and follow-up of children and adolescents with celiac disease. J Pediatr Gastroenterol Nutr 75:369–386. https://doi.org/10.1097/MPG.0000000000003540
doi: 10.1097/MPG.0000000000003540
pubmed: 35758521
Kozioł-Kozakowska A, Salamon D, Grzenda-Adamek Z, Krawczyk A, Duplaga M, Gosiewski T, Kowalska-Duplaga K (2021) Changes in diet and anthropometric parameters in children and adolescents with celiac diseases-one year follow-up. Nutrients 13:4306. https://doi.org/10.3390/nu13124306
doi: 10.3390/nu13124306
pubmed: 34959858
pmcid: 8703461
Anafy A, Cohen S, Ben Tov A et al (2021) The effect of gluten -free diet on body mass index in paediatric celiac disease. Acta Paediatr 110:2233–2239
doi: 10.1111/apa.15787
pubmed: 33529351
Costa A, Brito GAP (2019) Anthropometric parameters in celiac disease: a review on the different evaluation methods and disease effects. J Nutr Metab 2019:4586963. https://doi.org/10.1155/2019/4586963
doi: 10.1155/2019/4586963
pubmed: 31583132
pmcid: 6754920
Aydogdu S, Midyat L, Cakir M, Tumgor G, Yuksekkaya HA, Baran M, Arikan C, Ozgenc F, Yagci RV (2009) Long-term effect of gluten-free diet on growth velocity in Turkish children with celiac disease. Dig Dis Sci 54:2183–2187. https://doi.org/10.1007/s10620-008-0596-0
doi: 10.1007/s10620-008-0596-0
pubmed: 19057999
Mehta NM, Corkins MR, Lyman B, Malone A, Goday PS, Carney LN, Monczka JL, Plogsted SW, Schwenk WF (2013) American Society for Parenteral and Enteral Nutrition Board of Director. Defining pediatric malnutrition: a paradigm shift toward etiology-related definitions. JPEN J Parenter Enter Nutr 37:460–481. https://doi.org/10.1177/0148607113479972
Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, Wei R, Curtin LR, Roche AF, Johnson CL (2002) 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 11(11):1–190
World Health Organization. Multicentre Growth Reference Study Group. WHO child growth standards: length, height for-age, weight-for-age, weight-for-length and body mass index-for age: methods and development. Watch Web site, www.who.int/publications/i/item/924154693X . Published November 11, 2006
Husby S, Koletzko S, Korponay-Szabó I, Kurppa K, Mearin ML, Ribes-Koninckx C, Shamir R, Troncone R, Auricchio R, Castillejo G et al (2020) European Society Paediatric Gastroenterology, Hepatology and Nutrition guidelines for diagnosing coeliac disease 2020. J Pediatr Gastroenterol Nutr 70:141–156. https://doi.org/10.1097/MPG.0000000000002497
doi: 10.1097/MPG.0000000000002497
pubmed: 31568151
Krauthammer A, Guz-Mark A, Zevit N, Marderfeld L, Waisbourd-Zinman O, Silbermintz A, Mozer-Glassberg Y, Nachmias Friedler V, Rozenfeld Bar Lev M, Matar M et al (2020) Two decades of pediatric celiac disease in a tertiary referral center: what has changed? Dig Liver Dis 52:457–461. https://doi.org/10.1016/j.dld.2020.02.001
Comba A, Çaltepe G, Yüce Ö, Erena E, Kalaycı AG (2018) Effects of age of diagnosis and dietary compliance on growth parameters of patients with celiac disease. Arch Argent Pediatr 116:248–255. https://doi.org/10.5546/aap.2018.eng.248
doi: 10.5546/aap.2018.eng.248
pubmed: 30016020
Weiss B, Skourikhin Y, Modan-Moses D, Broide E, Fradkin A, Bujanover Y (2008) Is adult height of patients with celiac disease influenced by delayed diagnosis? Am J Gastroenterol 103:1770–1774. https://doi.org/10.1111/j.1572-0241.2008.01844.x
doi: 10.1111/j.1572-0241.2008.01844.x
pubmed: 18557713
Sansotta N, Guandalini S, Romano S, Amirikian K, Cipolli M, Tridello G, Barzaghi S, Jericho H (2020) The gluten free diet’s impact on growth in children with celiac disease in two different countries. Nutrients 12:1547. https://doi.org/10.3390/nu12061547
doi: 10.3390/nu12061547
pubmed: 32466557
pmcid: 7352316
Reilly NR, Aguilar K, Hassid BG, Cheng J, Defelice AR, Kazlow P, Bhagat G, Green PH (2011) Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. J Pediatr Gastroenterol Nutr 53:528–531. https://doi.org/10.1097/MPG.0b013e3182276d5e
doi: 10.1097/MPG.0b013e3182276d5e
pubmed: 21670710
Sonti R, Lebwohl B, Lewis SK, Abu Daya H, Klavan H, Aguilar K, Green PH (2013) Men with celiac disease are shorter than their peers in the general population. Eur J Gastroenterol Hepatol 25:1033–1037. https://doi.org/10.1097/MEG.0b013e328362e461
doi: 10.1097/MEG.0b013e328362e461
pubmed: 23743561
Villanueva M, Oyarzún A, Leyton B, González M, Navarro E, Canales P, Ossa C, Muñoz MP, Bascuñán KA, Araya M (2020) Changes in age at diagnosis and nutritional course of celiac disease in the last two decades. Nutrients 12:156. https://doi.org/10.3390/nu12010156
doi: 10.3390/nu12010156
pubmed: 31935859
pmcid: 7019995
Soliman AT, Laham M, Jour C, Shaat M, Souikey F, Itani M, Al-Safi A, Karmallah A, Qudaisat A, Alarabi Z et al (2019) Linear growth of children with celiac disease after the first two years on gluten- free diet: a controlled study. Acta Biomed 90:20–27. https://doi.org/10.23750/abm.v90i8-S.8515
doi: 10.23750/abm.v90i8-S.8515
pubmed: 31544803
pmcid: 7233684
Bosio L, Barera G, Mistura L, Sassi G, Bianchi C (1990) Growth acceleration and final height after treatment for delayed diagnosis of celiac disease. J Pediatr Gastroenterol Nutr 11:324–329. https://doi.org/10.1097/00005176-199010000-00007
doi: 10.1097/00005176-199010000-00007
pubmed: 2246713
Mozer-Glassberg Y, Zevit N, Rosenbach Y, Hartman C, Morgenstern S, Shamir R (2011) Follow-up of children with celiac disease -lost in translation? Digestion 83:283–287. https://doi.org/10.1159/000320714
doi: 10.1159/000320714
pubmed: 21282953
Blansky BA, Hintze ZJ, Alhassan E, Leichtner AM, Weir DC, Silvester JA (2019) Lack of follow up of pediatric patients with celiac disease. Clin Gastroenterol Hepatol 17:2603–2604. https://doi.org/10.1016/j.cgh.2018.12.027
doi: 10.1016/j.cgh.2018.12.027
pubmed: 30597204